Overview
- Editors:
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Kyriacos Felekkis
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Department of Life and Health Sciences and University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus
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Konstantinos Voskarides
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Department of Biological Sciences, Molecular Medicine Research Center, University of Cyprus, Nicosia, Cyprus
Includes information and novel functions about all the known genomic elements in a single publication
Discusses the physiologic function of these elements their role in disease and evolution
This book is dedicated exclusively to non-coding genomic elements
Includes supplementary material: sn.pub/extras
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Table of contents (12 chapters)
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- Konstantinos Voskarides, Kyriacos Felekkis
Pages 1-15
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- Ioannis S. Vizirianakis, Elsa P. Amanatiadou, Sotirios S. Tezias
Pages 109-127
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- Carolina Sismani, Costas Koufaris, Konstantinos Voskarides
Pages 129-154
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- Vasiliki A. Galani, Sofia Markoula, Leandros Lazaros, Paris Ladias, Ioannis Georgiou
Pages 155-193
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- María Dolores Molina-Sánchez, Rafael Nisa-Martínez, Fernando M. García-Rodríguez, Francisco Martínez-Abarca, Nicolás Toro
Pages 195-219
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- Thian Thian Beh, Paul Kalitsis
Pages 221-245
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- Penelope Kroustallaki, Sarantis Gagos
Pages 247-283
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Back Matter
Pages 313-315
About this book
Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.
Reviews
“This is the first time I have seen a volume on genomics from the island of Cyprus. … The chapters are well written, are of high quality, and the references cited reflect an intimate knowledge of current literature. … This is a useful source for an introduction to the noncoding regions of the human genome.” (Krishna Dronamraju, The Quarterly Review of Biology, Vol. 92 (2), June, 2017)
Editors and Affiliations
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Department of Life and Health Sciences and University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus
Kyriacos Felekkis
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Department of Biological Sciences, Molecular Medicine Research Center, University of Cyprus, Nicosia, Cyprus
Konstantinos Voskarides
