Abstract
Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005–1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686–691, 2013; Singh and Topham, Ophthalmology 110:956–961, 2003). Often diagnosed late due to a lack of early symptoms, this kind of melanoma is associated with a poor prognosis. Approximately 50 % of the patients develop distant metastases (Lipski, Klin Monbl Augenheilkd 230:1005–1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686–691, 2013; Singh and Topham, Ophthalmology 110:956–961, 2003). In sharp contrast to cutaneous melanoma, uveal melanoma shows a strong liver tropism and spreads exclusively via the hematogenous route (except for tumors with extraocular expansion) (Heindl et al., Arch Ophthalmol 128:1001–1008, 2010). The most likely reason for this observation is the lack of lymphatic vessels in the choroid and alymphatic barrier of the sclera (Schlereth et al., Exp Eye Res 125:203–209, 2014; Schroedl et al., Invest Ophthalmol Vis Sci 49:5222–5229, 2008). Due to its location in the immune-privileged eye, the uveal melanoma is widely protected from the immune system. Therefore, the goal of the approach presented here, of a “personalized vaccination therapy” is to help the immune system recognize and fight the tumor.
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Lipski AC et al (2013) Diagnosis of and therapy for choroidal melanoma. Klin Monbl Augenheilkd 230:1005–1019
Metz CH et al (2013) Uveal melanoma: current insights into clinical relevance of genetic testing. Klin Monbl Augenheilkd 230:686–691
Singh AD, Topham A (2003) Incidence of uveal melanoma in the United States: 1973–1997. Ophthalmology 110:956–961
Heindl LM et al (2010) Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread? Arch Ophthalmol 128:1001–1008
Schlereth SL et al (2014) Absence of lymphatic vessels in the developing human sclera. Exp Eye Res 125:203–209
Schroedl F et al (2008) The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages. Invest Ophthalmol Vis Sci 49:5222–5229
Prescher G et al (1996) Prognostic implications of monosomy 3 in uveal melanoma. Lancet 347:1222–1225
Moser JC et al (2015) The Mayo Clinic experience with the use of kinase inhibitors, ipilimumab, bevacizumab, and local therapies in the treatment of metastatic uveal melanoma. Melanoma Res 25:59–63
Shields JA, Shields CL (2015) Management of posterior uveal melanoma: past, present, and future: the 2014 Charles L. Schepens lecture. Ophthalmology 122:414–428
Tarlan B, Kiratli H (2012) Current treatment of choroidal melanoma. Expert Rev Ophthalmol 7:189–195
Schuler G, Schuler-Thurner B, Steinman RM (2003) The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 15:138–147
Wilgenhof S et al (2015) Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases. Cancer Immunol Immunother 64:381–388
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Kummer, M., Schuler-Thurner, B. (2017). Immunotherapy of Uveal Melanoma: Vaccination Against Cancer. In: Kramps, T., Elbers, K. (eds) RNA Vaccines. Methods in Molecular Biology, vol 1499. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6481-9_17
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DOI: https://doi.org/10.1007/978-1-4939-6481-9_17
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