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Angiogenic Signalling Pathways

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Angiogenesis Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 467))

Abstract

There is a need for direct imaging of effects on tumour vasculature in assessment of response to anti-angiogenic drugs and vascular disrupting agents. Imaging tumour vasculature depends on differences in permeability of vasculature of tumour and normal tissue, which cause changes in penetration of contrast agents. Angiogenesis imaging may be defined in terms of measurement of tumour perfusion and direct imaging of the molecules involved in angiogenesis. In addition, assessment of tumour hypoxia will give an indication of tumour vasculature. The range of imaging techniques available for these processes includes positron emission tomography (PET), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), perfusion computed tomography (CT), and ultrasound (US).

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Acknowledgements

We acknowledge Professor K. Miles, Dr. D. Buckley and Dr. J. Matthews for their advice.

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Authors and Affiliations

  1. University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK

    Natalie Charnley MBCHB, MRCP, FRCR

  2. North Western Medical Physics, Christie Hospital, Manchester, and Imaging Science and Biomedical Engineering, University of Manchester, UK

    Stephanie Donaldson MSC, MSCI

  3. Academic Department of Radiation Oncology, Christie Hospital, Manchester, UK

    Pat Price FRCR, MD

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  1. Natalie Charnley MBCHB, MRCP, FRCR
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  2. Stephanie Donaldson MSC, MSCI
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  3. Pat Price FRCR, MD
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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Charnley, N., Donaldson, S., Price, P. (2009). Angiogenic Signalling Pathways. In: Murray, C., Martin, S. (eds) Angiogenesis Protocols. Methods in Molecular Biology, vol 467. Humana Press. https://doi.org/10.1007/978-1-59745-241-0_2

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    • DOI: https://doi.org/10.1007/978-1-59745-241-0_2

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    • Publisher Name: Humana Press

    • Print ISBN: 978-1-58829-907-9

    • Online ISBN: 978-1-59745-241-0

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