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Bone-Mineral Homeostasis and Associated Pathologies

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Bone and Development

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

Bone-mineral homeostasis (homoióstasis = equilibrium in Greek) is the result of the interplay of two intertwined endocrine circuits formed by the feedback-regulated actions of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and parathyroid hormone (PTH). Partially divergent effects of two hormones on calcium and phosphate fluxes in the classical target organs (intestine, kidney, and bone) have to be carefully orchestrated at any time during the life of a vertebrate organism to meet the ever-changing demands of bone growth and functions. This can only be achieved if the input into the system from the outside will allow it to adjust itself to different functional levels, i.e., to promote longitudinal growth during development, to build up an adequate peak bone mass through appositional bone growth until 20-30 years of age, to meet the specific challenge for bone-mineral homeostasis during pregnancy, and finally to maintain structural and functional integrity as long as possible in the face of continuous involutional bone loss throughout adulthood.

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Notes

  1. 1.

    1The term 25-(OH)D is used to denote the sum of 25-(OH)D3 and 25-(OH)D2, the latter from dietary sources.

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Authors and Affiliations

  1. Department of Pathophysiology, Medical University of Vienna, Vienna, AUT

    Meinrad Peterlik

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  1. Meinrad Peterlik
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  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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Peterlik, M. (2010). Bone-Mineral Homeostasis and Associated Pathologies. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_15

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  • DOI: https://doi.org/10.1007/978-1-84882-822-3_15

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