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Bioactive Lipids in Health and Disease pp 97–115Cite as

Lipid Metabolism and Signaling in Platelet Function

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1127))

Abstract

Modern society has changed its diet composition, transitioning to a higher intake of saturated fat with a 50% increase of cardiovascular risk (CVD). Within the context of increased CVD, there is an induction of a prothrombotic phenotype mainly due to increased platelet reactivity as well as decreased platelet response to inhibitors. Platelets maintain haemostasis through both blood components and endothelial cells that secrete inhibitory or stimulatory molecules to regulate thrombus formation. There exist a correlation between platelets’ polyunsaturated fatty acid (PUFA) and the increase in platelet reactivity. The aim of this chapter is to review the metabolism of the main PUFAs involved in platelet function associated with the role that their enzyme-derived oxidized metabolites exert in platelet function and fate. Finally, how lipid metabolism in the organism affect platelet aggregation and activation and the pharmacological modulation of these processes will also be discussed.

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Authors and Affiliations

  1. Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil

    Antonio Marcus de Andrade Paes

  2. Institute of Cardiovascular and Metabolic Research, University of Reading, Reading, UK

    Renato Simões Gaspar

  3. Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile

    Eduardo Fuentes, Sergio Wehinger & Iván Palomo

  4. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Andrés Trostchansky

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  1. Antonio Marcus de Andrade Paes
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  2. Renato Simões Gaspar
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  3. Eduardo Fuentes
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  4. Sergio Wehinger
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  5. Iván Palomo
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  6. Andrés Trostchansky
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Correspondence to Andrés Trostchansky .

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Editors and Affiliations

  1. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Andres Trostchansky

  2. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Homero Rubbo

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Paes, A.M.d.A., Gaspar, R.S., Fuentes, E., Wehinger, S., Palomo, I., Trostchansky, A. (2019). Lipid Metabolism and Signaling in Platelet Function. In: Trostchansky, A., Rubbo, H. (eds) Bioactive Lipids in Health and Disease. Advances in Experimental Medicine and Biology, vol 1127. Springer, Cham. https://doi.org/10.1007/978-3-030-11488-6_7

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