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Limiting Life-Sustaining Therapies

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Abstract

In many critically ill patients, it is uncertain whether the chance of survival and recovery justifies the suffering that is associated with (prolonged) life support. This chapter discusses the circumstances when limiting life-sustaining therapies may be permissible, advisable, or even imperative. Differences between withholding and withdrawing are commented on as well as the role of intensity- or time-limited treatment trials. We discuss strategies to make careful decisions on limiting life-sustaining therapies and suggest how withdrawal of life support can be implemented.

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References

  1. Sprung CL, Ricou B, Hartog CS, et al. Changes in end-of-life practices in European intensive care units from 1999 to 2016. JAMA. 2019;322:1–12.

    Google Scholar 

  2. Long AC, Brumback LC, Curtis JR, et al. Agreement with consensus statements on end-of-life care: a description of variability at the level of the provider, hospital, and country. Crit Care Med. 2019;47:1396–401.

    Article  Google Scholar 

  3. Mark N, Rayner SG, Lee NJ, et al. Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review. Intensive Care Med. 2015;41:1572–85.

    Article  CAS  Google Scholar 

  4. Garland A, Connors F. Physicians influence over decisions to forego life support. J Palliat Med. 2007;10:1298–305.

    Article  Google Scholar 

  5. Sprung CL, Cohen SL, Sjokvist P, et al. End-of-life practices in European intensive care units: the Ethicus study. JAMA. 2003;290:790–7.

    Article  Google Scholar 

  6. Sprung CL, Truog RD, Curtis JR, et al. Seeking worldwide professional consensus on the principles of end-of-life care for the critically ill. The consensus for worldwide end-of-life practice for patients in intensive care units (WELPICUS) study. Am J Respir Crit Care Med. 2014;190:855–66.

    Article  Google Scholar 

  7. Beauchamp TL, Childress JF. Principles of biomedical ethics. 8th ed. Oxford: Oxford University Press; 2019.

    Google Scholar 

  8. Michalsen A, Long AC, DeKeyser-Ganz F, et al. Interprofessional shared decision-making in the ICU: a systematic review and recommendations from an expert panel. Crit Care Med. 2019;47:1258–66.

    Article  Google Scholar 

  9. Kon AA, Davidson JE, Morrison W, et al. Shared decision-making in ICUs: an American College of Critical Care Medicine and American Thoracic Society policy statement. Crit Care Med. 2016;44:188–201.

    Article  Google Scholar 

  10. Neitzke G, Burchardi H, Duttge G, et al. Limits to the appropriateness of intensive care medicine. Policy statement of the German Interdisciplinary Association of Intensive Care and Emergency Medicine. Med Klin Intensivmed Notfmed. 2019;114:46–52.

    Article  CAS  Google Scholar 

  11. Bosslet GT, Pope TM, Rubenfeld GD, et al. An official ATS/AACN/ACCP/ESICM/SCCM policy statement: responding to requests for potentially inappropriate treatments in intensive care units. Am J Respir Crit Care Med. 2015;191:1318–30.

    Article  Google Scholar 

  12. Marseille E, Kahn JG. Utilitarianism and the ethical foundations of cost-effectiveness analysis in resource allocation for global health. Philos Ethics Humanit Med. 2019;14:5.

    Article  Google Scholar 

  13. McKie J, Richardson J. The rule of rescue. Soc Sci Med. 2003;56:2407–19.

    Article  Google Scholar 

  14. Wilkinson D, Butcherine E, Savulescu J. Withdrawal aversion and the equivalence test. Am J Bioeth. 2019;19:21–8.

    Article  Google Scholar 

  15. Sprung CL, Paruk F, Kissoon, et al. The Durban world congress ethics round table conference report: I. differences between withholding and withdrawing life-sustaining treatments. J Cirt Care. 2014;29:890–5.

    Article  Google Scholar 

  16. Ursin LØ. Withholding and withdrawIng life-sustaing treatment: ehtically equivalent. Am J Bioeth. 2019;19:10–20.

    Article  Google Scholar 

  17. Emmerich N, Gordijn B. Beyond the equivalence thesis: how to think about the ethics of withdrawing and withholding life-saving medical treatment. Theor Med Bioeth. 2019;40:21–41.

    Article  Google Scholar 

  18. Phua J, Joynt GM, Nishimura M, et al. Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions. Intensive Care Med. 2016;42:1118–27.

    Article  Google Scholar 

  19. Vink EE, Azoulay E, Caplan A, et al. Time-limited trial of intensive care treatment: an overview of current literature. Intensive Care Med. 2018;44:1369–77.

    Article  Google Scholar 

  20. Quill TE, Holloway R. Time-limited trials near the end of life. JAMA. 2011;306:1483–4.

    Article  CAS  Google Scholar 

  21. Joynt GM, Lipman J, Hartog C, et al. The Durban world congress ethics round table IV: health care professional end-of-life decision making. J Crit Care. 2014;30:224–30.

    Article  Google Scholar 

  22. Benoit DD, Jensen HI, Malmgren J, et al. Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA. Intensive Care Med. 2018;44:1039–49.

    Article  CAS  Google Scholar 

  23. Epker JL, Bakker J, Lingsma HF, et al. An observational study on a protocol for withdrawal of life-sustaining measures on two non-academic intensive care units in the Netherlands: few signs of distress, no suffering? J Pain Symptom Manag. 2015;50:676–84.

    Article  Google Scholar 

  24. Ely EW, Azoulay E, Sprung CL. Eight things we would never do regarding end-of-life care in the ICU. Intensive Care Med. 2019;45:1116–8.

    Article  Google Scholar 

  25. Wang D, Creel-Bulos C. A systematic approach to comfort care transitions in the emergency department. J Emerg Med. 2019;56:267–74.

    Article  Google Scholar 

  26. Robert R, Le Gouge A, Kentish-Barnes N, et al. Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study). Intensive Care Med. 2017;43:1793–807.

    Article  Google Scholar 

  27. Downar J, Delaney JW, Hawryluck L, et al. Guidelines for the withdrawal of life-sustaining measures. Intensive Care Med. 2016;42:1002–27.

    Google Scholar 

  28. Cook D, Rocker G. Dying with dignity in the intensive care unit. N Engl J Med. 2014;370:2506–14.

    Article  CAS  Google Scholar 

  29. Petrinec AB, Martin BR. Post-intensive care syndrome symptoms and health-related quality of life in family decision-makers of critically ill patients. Palliat Support Care. 2018;16:719–24.

    Article  Google Scholar 

  30. Neitzke G, Böll B, Burchardi H, et al. Documentation of decisions to withhold or withdraw life-sustaining therapies: recommendation of the Ethics Section of the German Interdisciplinary Association of Critical Care and Emergency Medicine (DIVI) in collaboration with the Ethics Section of the German Society for Medical Intensive Care and Emergency Medicine (DGIIN). Med Klin Intensivmed Notfmed. 2017;112:527–30. [Erratum: Med Klin Intensivmed Notfmed 2017; 112:530].

    Article  CAS  Google Scholar 

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Correspondence to Diederik van Dijk .

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van Dijk, D., Boulanger, C., Joynt, G., Michalsen, A., Bakker, J. (2020). Limiting Life-Sustaining Therapies. In: Michalsen, A., Sadovnikoff, N. (eds) Compelling Ethical Challenges in Critical Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-43127-3_11

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  • DOI: https://doi.org/10.1007/978-3-030-43127-3_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-43126-6

  • Online ISBN: 978-3-030-43127-3

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