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The Role of Inflammation in Skin Cancer

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Inflammation and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 816))

Abstract

Cancer is an environmental disease and skin cancer (melanoma and non-melanoma) is the most common of all cancers. Epidemiological and experimental evidence suggest “chronic inflammation” to be one of the hallmarks in solar ultraviolet radiation and several other environmental agent-mediated skin cancers. The identification of transcription factors, mainly nuclear factor-kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 alpha (HIF-1α) and their gene products i.e. prostaglandins, cyclooxygenase-2 (COX-2), cytokines [tumor necrosis factor- alpha (TNF-α)], chemokines [CXC-chemokine ligand (CXCL)] and chemokine receptors suggest critical role of inflammation in skin carcinogenesis. Considering the potential role of inflammation in tumor initiation and its major role in promotion/progression, as well as tumor angiogenesis and metastasis; inflammatory pathways may become attractive targets for skin cancer prevention. Hence this review focuses on compiling available evidence and understanding the role of chronic inflammation in the development of skin cancer.

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Acknowledgments

We thank Dr. Vikram Gota for useful discussion and Council of Scientific and Industrial Research (CSIR) and ACTREC, Government of India, for awarding fellowship to Mr. Gaurav Kumar.

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  1. Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Sector-22, Kharghar, Navi Mumbai, 410210, India

    Girish B. Maru, Khushboo Gandhi, Asha Ramchandani & Gaurav Kumar

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  1. Girish B. Maru
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  2. Khushboo Gandhi
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  3. Asha Ramchandani
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  4. Gaurav Kumar
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Correspondence to Girish B. Maru .

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  1. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

  2. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bokyung Sung

  3. Dep Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Subash Chandra Gupta

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Maru, G.B., Gandhi, K., Ramchandani, A., Kumar, G. (2014). The Role of Inflammation in Skin Cancer. In: Aggarwal, B., Sung, B., Gupta, S. (eds) Inflammation and Cancer. Advances in Experimental Medicine and Biology, vol 816. Springer, Basel. https://doi.org/10.1007/978-3-0348-0837-8_17

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