Skip to main content
SpringerLink
Log in
Book cover

Tetracyclines in Biology, Chemistry and Medicine pp 267–281Cite as

Birkhäuser

Inhibition of matrix metalloproteinases (MMPs) by tetracyclines

  • Chapter

Abstract

Remodelling of the extracellular matrix and destruction of connective tissue are regarded as characteristic features of degenerative and invasive processes such as rheumatoid arthritis, periodontitis, wound healing, tumour growth and metastatic invasion. Matrix remodelling is a complex process in which matrix metalloproteinases (MMPs) play a central role. MMP activity arises from a multi-step process, which is tightly regulated. Overexpression and activation of MMPs are correlated with a number of pathologies.

Tetracyclines and tetracycline derivatives are able to inhibit MMP activity, independent of their anti-microbial action. The various MMPs have a different sensitivity for inhibition by tetracyclines: it is the strongest for MMP-8 and MMP-13, and weak or absent for MMP-1 and MMP-3. Inhibition ofin vitroactivity is strongly dependent on the assay conditions used (pH, kind of substrate, source of enzyme). Besides activity, the activation step of MMPs and MMP synthesis are also tetracycline-sensitive, varying per MMP. For a number of MMPs (MMP-8, MMP-9 and MMP-13), inhibition occurs at tetracycline levels which are physiologically obtainable upon therapy. In general, MMP inhibition by tetracyclines is observed in cells activated by growth factors or inflammatory mediators, in which MMP expression is induced. No effect of tetracyclines on the synthesis and action of TIMPs, inhibitors of MMPs, was observed.

Use of tetracyclines in animal models and human diseases, in which MMPs play a role, reflects thein vitrosituation: inhibition of MMP synthesis and reduction or prevention of the pathological condition.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Woessner JF (1993) Introduction to serial reviews — the extracellular matrix.FASEB J7: 1191–1191

    Google Scholar 

  2. Damjanovski S, Ishizuya-Oka A, Shi YB (1999) Spatial and temporal regulation of collagenases-3, -4, and stromelysin-3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis.Cell Res9: 91–105

    Article  PubMed  CAS  Google Scholar 

  3. Stetler Stevenson WG (1999) Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention.J Clin Invest103: 1237–1241

    Article  PubMed  CAS  Google Scholar 

  4. Soo C, Shaw WW, Zhang X, Longaker MT, Howard EW, Ting K (2000) Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair.Plast Reconstr Surg105: 638–647

    Article  PubMed  CAS  Google Scholar 

  5. Kahari VM, Saarialhokere U (1999) Matrix metalloproteinases and their inhibitors in tumour growth and invasion.Ann Med31: 34–45

    Article  PubMed  CAS  Google Scholar 

  6. Delclaux C, Delacourt C, Dortho MP, Boyer V, Lafuma C, Harf A (1996) Role of gelatinase b and elastase in human polymorphonuclear neutrophil migration across basement membrane.Amer J Respir Cell Mol Biol14: 288–295

    CAS  Google Scholar 

  7. Unemori EN, Bouhana KS, Werb Z (1990) Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells.J Biol Chem265: 445–451

    PubMed  CAS  Google Scholar 

  8. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells.Nature370: 61–65

    Article  PubMed  CAS  Google Scholar 

  9. Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JPM, Shipley M, Angellilo A et al (1999) Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.Nat Med5: 1135–1142

    Article  PubMed  CAS  Google Scholar 

  10. Sepper R, Konttinen YT, Buo L, Eklund KK, Lauhio A, Sorsa T, Tschesche H, Aasen AO, Sillastu H (1997) Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin g and tryptase in bronchiectasisin vivo. Eur Resp J10: 2788–2793

    CAS  Google Scholar 

  11. Capodici C, Berg RA (1991) Neutrophil Collagenase Activation — the role of oxidants and cathepsin-G.Agents Actions34: 8–10

    Article  PubMed  CAS  Google Scholar 

  12. Sorsa T, Salo T, Koivunen E, Tyynela J, Konttinen YT, Bergmann U, Tuuttila A, Niemi E, Teronen O, Heikkila P et al (1997) Activation of type IV procollagenases by human tumor-associated trypsin-2.J Biol Chem272: 21067–21074

    Article  PubMed  CAS  Google Scholar 

  13. Brown PD (1999) Clinical studies with matrix metalloproteinase inhibitors.APMIS107: 174–180

    Article  PubMed  CAS  Google Scholar 

  14. Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T (1998)In vitrosensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.Bone22: 33–38

    Article  PubMed  Google Scholar 

  15. Saivin S, Houin G (1988) Clinical pharmakokinetics of doxycylcine and minocycline.Clin Pharmacokinet15: 355–366

    Article  PubMed  CAS  Google Scholar 

  16. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR (1991) Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs.Crit Rev Oral Biol Med2: 297–322

    PubMed  CAS  Google Scholar 

  17. Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT (1995) Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva.J Clin Periodontol22: 100–109

    Article  PubMed  CAS  Google Scholar 

  18. Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Talceha S, Konttinen YT (1994) Effects of tetracyclines on neutrophil, gingival, and salivary collagenases.Ann N Y Acad Sci732: 112–131

    Article  PubMed  CAS  Google Scholar 

  19. Lindy O, Konttinen YT, Sorsa T, Ding YL, Santavirta S, Ceponis A, Lopezotin C (1997) Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.Arthritis Rheum40: 1391–1399

    Article  PubMed  CAS  Google Scholar 

  20. Sorsa T, Ramamurthy NS, Vernillo AT, Zhang X, Konttinen YT, Rifkin BR, Golub LM (1998) Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.J Rheumatol25: 975–982

    PubMed  CAS  Google Scholar 

  21. Lukkonen A, Sorsa T, Salo T, Tervahartiala T, Koivunen E, Golub L, Simon S, Stenman U H (2000) Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration.Int J Cancer86: 577–581

    Article  PubMed  CAS  Google Scholar 

  22. Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, Pflugfelder SC (2000) Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant.Invest Ophthalmol Visual Sci41: 1703–1709

    CAS  Google Scholar 

  23. Smith GN, Mickler EA, Hasty KA, Brandt KD (1999) Specificity of inhibition of matrix metalloproteinase activity by doxycycline — relationship to structure of the enzyme.Arthritis Rheum42: 1140–1146

    Article  PubMed  CAS  Google Scholar 

  24. Smith GN, Brandt KD, Mickler EA, Hasty KA (1997) Inhibition of recombinant human neutrophil collagenase by doxycycline is pH dependent.J Rheumatol24: 1769–1773

    PubMed  CAS  Google Scholar 

  25. Golub LM, Lee HM, Greenwald RA, Ryan ME, Sorsa T, Salo T, Giannobile WV (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.Inflamm Res46: 310–319

    Article  PubMed  CAS  Google Scholar 

  26. Curci JA, Mao DL, Bohner DG, Allen BT, Rubin BG, Reilly JM, Sicard GA, Thompson RW (2000) Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms.J Vasc Surg31: 325–341

    Article  PubMed  CAS  Google Scholar 

  27. Baragi VM, Jonat C, Renkiewicz R, Qui L, Man CF (1998) Effects of tetracycline on cartilage degradation and matrix metalloproteinase activity/expression.Adv Dent Res12: 68–70

    Article  Google Scholar 

  28. Shlopov BV, Smith GN, Cole AA, Hasty KA (1999) Differential patterns of response to doxycycline and transforming growth factor beta 1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes.Arthritis Rheum42: 719–727

    Article  PubMed  CAS  Google Scholar 

  29. Hanemaaijer R, Sorsa T, Konttinen YT, Ding YL, Sutinen M, Visser H, Vanhinsbergh VWM, Helaakoski T, Kainulainen T, Ronka H (1997) Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells — regulation by tumor necrosis factor-alpha and doxycycline.J Biol Chem272: 31504–31509

    Article  PubMed  CAS  Google Scholar 

  30. Hanemaaijer R, Visser H, Koolwijk P, Sorsa T, Salo T, Golub LM, van Hinsberg VWM (1998) Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells.Adv Dent Res12: 114–118

    Article  PubMed  CAS  Google Scholar 

  31. Jonat C, Chung FZ, Baragi VM (1996) Transcriptional downregulation of stromelysin by tetracycline.J Cell Biochem60: 341–347

    Article  PubMed  CAS  Google Scholar 

  32. Uitto VJ, Firth JD, Nip L, Golub LM (1994) Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes.Ann NYAcad Sci732: 140–151

    Article  CAS  Google Scholar 

  33. Porter KE, Thompson MM, Loftus IM, Mcdermott E, Jones L, Crowther M, Bell PR, London NJ (1999) Production and inhibition of the gelatinolytic matrix metalloproteinases in a human model of vein graft stenosis.Eur J Vasc Endovasc Surg17: 404–412

    Article  PubMed  CAS  Google Scholar 

  34. Petrinec D, Liao SX, Holmes DR, Reilly JM, Parks WC, Thompson RW (1996) Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kd gelatinase.J Vasc Surg23: 336–346

    Article  PubMed  CAS  Google Scholar 

  35. Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, Ennis TL, Shapiro SD, Senior RM, Thompson RW (2000) Targeted gene disruption of matrix metalloproteinase-9 (Gelatinase B) suppresses development of experimental abdominal aortic aneurysms.J Clin Invest105: 1641–1649

    Article  PubMed  CAS  Google Scholar 

  36. Ramamurthy NS, McClain SA, Pirila E, Maisi P, Salo T, Kucine A, Sorsa T, Vishram F, Golub LM (1999) Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.Ann N YAcad Sci878: 720–723

    Article  CAS  Google Scholar 

  37. Beekman B, Verzijl N, Deroos JADM, Koopman JL, Tekoppele JM (1997) Doxycycline inhibits collagen synthesis by bovine chondrocytes cultured in alginate.J Paediat Endocrinol MeTab237: 107–110

    CAS  Google Scholar 

  38. Davies SR, Cole AA, Schmid TM (1996) Doxycycline inhibits type x collagen synthesis in avian hypertrophic chondrocyte cultures.J Biol Chem271: 25966–25970

    Article  PubMed  CAS  Google Scholar 

  39. Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB (1996) A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.Proc Natl Acad Sci USA93: 14014–14019

    Article  PubMed  CAS  Google Scholar 

  40. Trachtman H, Futterweit S, Greenwald R, Moak S, Singhal P, Franki N, Amin AR (1996) Chemically modified tetracyclines inhibit inducible nitric oxide synthase expression and nitric oxide production in cultured rat mesangial cells.J Paediat Endocrinol Metab229: 243–248

    CAS  Google Scholar 

  41. Cillari E, Milano S, D’ Agostino P, Di Bella G, La Rosa M, Barbera C, Ferlazzo V, Cammarata G, Grimaudo S, Tolomeo M et al (1998) Modulation of nitric oxide production by tetracyclines and chemically modified tetracyclines.Adv Dent Res12: 126–130

    Article  PubMed  CAS  Google Scholar 

  42. Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrel LA, Hersch SM et al (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a trans-genic mouse model of Huntington disease.Nat Med6: 797–801

    Article  PubMed  CAS  Google Scholar 

  43. Ashley RA (1999) Clinical trials of a matrix metalloproteinase inhibitor in human periodontal disease. SDD Clinical Research Team.Ann NYAcad Sci878: 335–346

    Article  CAS  Google Scholar 

  44. Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, Mcculloch CAG (1999) Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases.J Periodontol70: 1292–1302

    Article  PubMed  CAS  Google Scholar 

  45. Anonymus (1998) Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. The UK Small Aneurysm Trial Participants.Lancet352: 1649–1655

    Article  Google Scholar 

  46. Satta J, Laurila A, Paakko P, Haukipuro K, Sormunen R, Parkkila S, Juvonen T (1998) Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study.Eur J Vasc Endovasc Surg15: 313–319

    Article  PubMed  CAS  Google Scholar 

  47. Knox JB, Sukhova GK, Whittemore AD, Libby P (1997) Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases.Circulation95: 205–212

    Article  PubMed  CAS  Google Scholar 

  48. Franklin IJ, Harley SL, Greenhalgh RM, Powell JT (1999) Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis.Brit J Surg86: 771–775

    Article  PubMed  CAS  Google Scholar 

  49. de Bri E, Lei W, Svensson O, Chowdhury M, Moak SA, Greenwald RA (1998) Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs.Adv Dent Res12: 82–85

    Article  PubMed  Google Scholar 

  50. Lauhio A, Salo T, Ding Y, Konttinen YT, Nordstrom D, Tschesche H, Landevirta J, Golub LM, Sorsa T (1994)In vivoinhibition of human neutrophil collagenase (MMP-8) activity during longterm combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis.Clin Exp Immunol98: 21–28

    Article  PubMed  CAS  Google Scholar 

  51. Nordstrom D, Lindy O, Lauhio A, Sorsa T, Santavirta S, Konttinen YT (1998) Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis.Rheumatol Int17: 175–180

    Article  PubMed  CAS  Google Scholar 

  52. Lauhio A, Salo T, Tjaderhane L, Landevirta J, Golub LM, Sorsa T (1995) Tetracyclines in treatment of rheumatoid arthritis.Lancet346: 645–646

    Article  PubMed  CAS  Google Scholar 

  53. O’Dell JR, Paulsen G, Haire CE, Blakely K, Palmer W, Wees S, Eckhoff PJ, Klassen LW, Churchill M, Doud D et al (1999) Treatment of early seropositive rheumatoid arthritis with minocycline: four-year followup of a double-blind, placebo-controlled trial.Arthritis Rheum42: 1691–1695

    Article  PubMed  Google Scholar 

  54. Mccawley LJ, Matrisian LM (2000) Matrix metalloproteinases: multifunctional contributors to tumor progression.Mol Med Today6: 149–156

    Article  PubMed  CAS  Google Scholar 

  55. Aparicio T, Kermorgant S, Dessirier V, Lewin MJ, Lehy T (1999) Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats.Carcinogenesis20: 1445–1451

    Article  Google Scholar 

  56. Price A, Shi Q, Morris D, Wilcox ME, Brasher PM, Rewcastle NB, Shalinsky D, Zou H, Appelt K, Johnston RN et al (1999) Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.Clin Cancer Res5: 845–854

    PubMed  CAS  Google Scholar 

  57. An ZL, Wang XE, Willmott N, Chander SK, Tickle S, Docherty AJP, Mountain A, Millican AT, Morphy R, Porter JR, Epemolu RO, Kubota T, Moossa AR, Hoffman RM (1997) Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.Clin Exp Metastasis15: 184–195

    Article  PubMed  CAS  Google Scholar 

  58. Rosemurgy A, Harris J, Langleben A, Casper E, Goode S, Rasmussen H (1999) Marimastat in patients with advanced pancreatic cancer: a dose-finding study.Amer J Clin Oncol22: 247–252

    Article  CAS  Google Scholar 

  59. Cakir Y, Hahn KA (1999) Direct action by doxycycline against canine osteosarcoma cell proliferation and collagenase (MMP-1) activityin vitro. In Vivo13: 327–331

    PubMed  CAS  Google Scholar 

  60. Lokeshwar BL (1999) MMP inhibition in prostate cancer.Ann NYAcad Sci878: 271–289

    Article  CAS  Google Scholar 

  61. Seftor REB, Seftor EA, Delarco JE, Kleiner DE, Leferson J, Stetler Stevenson WG, McNamara TF, Golub LM, Hendrix MJC (1998) Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis.Clin Exp Metastasis16: 217–225

    Article  PubMed  CAS  Google Scholar 

  62. Sukhova GK, Schonbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P (1999) Evidence for increased collagenolysis by interstitial collagenases-1 and-3 in vulnerable human atheromatous plaques.Circulation99: 2503–2509

    Article  PubMed  CAS  Google Scholar 

  63. Li ZH, Li L, Zielke R, Cheng L, Xiao RP, Crow MT, Stetler Stevenson G, Froehlich J, Lakatta EG (1996) Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions.Amer J Pathol148: 121–128

    CAS  Google Scholar 

  64. Galis ZS, Sukhova GK, Lark MW, Libby P (1994) Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.J Clin Invest94: 2493–2503

    Article  PubMed  CAS  Google Scholar 

  65. Lijnen HR, Soloway P, Cohen D (1999) Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in mice.Circ Res85: 1186–1191

    Article  PubMed  CAS  Google Scholar 

  66. Rouis M, Adamy C, Duverger N, Lesnik P, Horellou P, Moreau M, Emmanuel F, Caillaud JM, Laplaud PM, Dachet C et al (1999) Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein e-deficient mice.Circulation100: 533–540

    Article  PubMed  CAS  Google Scholar 

  67. de Smet BJ, de Kleijn D, Hanemaaijer R, Verheijen JH, Robertus L, van Der H, Borst C, Post MJ (2000) Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic yucatan micropig.Circulation101: 2962–2967

    Article  PubMed  Google Scholar 

  68. Porter KE, Loftus IM, Peterson M, Bell PR, London NJ, Thompson MM (1998) Marimastat inhibits neointimal thickening in a model of human vein graft stenosis.Brit J Surg85: 1373–1377

    Article  PubMed  CAS  Google Scholar 

  69. Carney DE, Lutz CJ, Picone AL, Gatto LA, Ramamurthy NS, Golub LM, Simon SR, Searles B, Paskanik A, Snyder K et al (1999) Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.Circulation100: 400–406

    Article  PubMed  CAS  Google Scholar 

  70. Tjaderhane L, Sulkala M, Sorsa T, Teronen O, Larmas M, Salo T (1999) The effect of MMP inhibitor metastat on fissure caries progression in rats.Ann N Y Acad Sci878: 686–688

    Article  PubMed  CAS  Google Scholar 

  71. Noorman F, Braat EA, Rijken DC (1995) Degradation of tissue-type plasminogen activator by human monocyte-derived macrophages is mediated by the mannose receptor and by the low-density lipoprotein receptor-related protein.Blood86: 3421–3427

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gaubius Laboratory TNO-PG, P.O. Box 2215, Leiden, 2301 CE, The Netherlands

    Roeland Hanemaaijer

Authors
  1. Roeland Hanemaaijer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Natascha van Lent
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Timo Sorsa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tuula Salo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. YrjŐ
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. Konttinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jan Lindeman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Paratek Pharmaceuticals, 75 Kneeland St., Boston, MA, 02111, USA

    Mark Nelson

  2. Lehrstuhl für Mikrobiologie, Friedrich-Alexander Universität, Erlangen-Nürnberg Staudstr. 5, Erlangen, D-91058, Germany

    Wolfgang Hillen

  3. Division of Rheumatology, Long Island Jewish Medical Center, Suite 107 410 Lakeville Rd, New Hyde Park, NY, 11040, USA

    Robert A. Greenwald

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Basel AG

About this chapter

Cite this chapter

Hanemaaijer, R. et al. (2001). Inhibition of matrix metalloproteinases (MMPs) by tetracyclines. In: Nelson, M., Hillen, W., Greenwald, R.A. (eds) Tetracyclines in Biology, Chemistry and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8306-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8306-1_11

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9511-8

  • Online ISBN: 978-3-0348-8306-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation