Skip to main content
SpringerLink
Log in
Book cover

Brain Edema XIV pp 291–294Cite as

Neuromodulation with Pleiotropic and Multimodal Drugs – Future Approaches to Treatment of Neurological Disorders

  • Conference paper
  • First Online:

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 106))

Abstract

Neurologists are confronted with an ever-growing amount of new information regarding the intimate processes taking place in both normal and pathological brains. Concepts like neuroprotection, neurotrophicity, or anoikis and their clinical utility may be of dazzling complexity. This paper briefly reviews some of the mechanisms involved in the pathogenesis of neurological diseases and current therapies. Since it is becoming more and more clear that using neuroprotective molecule with only one mechanism of action in disease treatment is a utopist idea, the research and use of multimodal drugs should be encouraged.

It is not easy to find good therapeutic approaches to neurological disorders, especially if we do not have a deep understanding of all the basic endogenous biological processes, pathophysiological processes, and the links between them.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403–1413

    Article  PubMed  Google Scholar 

  2. Muresanu FD (2007) Neuroprotection and neuroplasticity – a holistic approach and future perspectives. J Neurol Sci 257:38–43

    Article  PubMed  Google Scholar 

  3. Muresanu FD (2003) Neurotrophic factors. Ed Libripress, Bucharest

    Google Scholar 

  4. Teter B, Ashford JW (2002) Neuroplasticity in Alzheimer’s disease. J Neurosci Res. Nov 1; 70(3):402–437

    Google Scholar 

  5. Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57:173–185

    Article  PubMed  CAS  Google Scholar 

  6. Frisch SM, Screaton RA (2001) Anoikis mechanisms. Curr Opin Cell Biol 13(5):555–562

    Article  PubMed  CAS  Google Scholar 

  7. Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation of N-Methyl-D-aspartate receptors by calpain in cortical neurons. J Biol Chem 280(22):21588–21593

    Article  PubMed  CAS  Google Scholar 

  8. Hutter-Paier B, Grygar E, Fruhwirth M, Temmel I, Windisch M (1998) Further evidence that Cerebrolysin protects cortical neurons from neurodegeneration in vitro. J Neural Transm Suppl 53:363–372

    Article  PubMed  CAS  Google Scholar 

  9. Hetman M, Kharebava G (2006) Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem 6:787–799

    Article  PubMed  CAS  Google Scholar 

  10. Brunet A, Datta SR, Greenberg (2001) M.E.Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11:297–305

    Google Scholar 

  11. Hardingham GE, Arnold FJ, Bading H (2001) A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci 4:565–566

    Article  PubMed  CAS  Google Scholar 

  12. Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405–414

    PubMed  CAS  Google Scholar 

  13. Arundine M, Tymianski M (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 61:657–668

    Article  PubMed  CAS  Google Scholar 

  14. Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P (2005) Calpain cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 120:275–285

    Article  PubMed  CAS  Google Scholar 

  15. Stout AK, Raphael HM, Kanterewicz BI, Klann E, Reynolds IJ (1998) Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci 1:366–373

    Article  PubMed  CAS  Google Scholar 

  16. Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE (2006) Preconditioning doses of nmda promote neuroprotection by enhancing neuronal excitability. J Neurosci 26:4509–4518

    Article  PubMed  CAS  Google Scholar 

  17. Ivanov A, Pellegrino C, Rama S, Dumalska I, Salyha Y, Ben-Ari Y, Medina I (2006) Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J Physiol 572:789–798

    PubMed  CAS  Google Scholar 

  18. Iseda T, Nishio T, Kawaguchi S, Yamanoto M, Kawasaki T, Wakisaka S (2004) Spontaneous regeneration of the corticospinal tract after transection in young rats: a key role of reactive astrocytes in making favourable and unfavourable conditions for regeneration. Neuroscience 126:365–374

    Article  PubMed  CAS  Google Scholar 

  19. Kotter MR, Setzu A, Sim FJ, Van Rooi-jen N, Franklin RJM (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35:204–212

    Article  PubMed  CAS  Google Scholar 

  20. Masson JL, Jones JJ, Taniike M, Morelll P, Suzuki K, Matsushima GK (2000) Mature oligodendrocytes apoptosis precedes IGF-I production: an oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. J Neurosci Res 61:251–262

    Article  Google Scholar 

  21. Arnett HA, Wang Y, Matsushima GK, Suzuki K, Ting JPY (2003) Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocytes regeneration. J Neurosci 23:9824–9832

    PubMed  CAS  Google Scholar 

  22. Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel ULM (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-d-aspartate receptor activation. J Biol Chem 279(31):32869–32881

    Article  PubMed  CAS  Google Scholar 

  23. Becher B, Antel JP (1996) Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia 18:1–10

    Article  PubMed  CAS  Google Scholar 

  24. Windhangen A, Newcombe J, Dan-gond F, Strand C, Woodroofe MNB, Cuzner ML et al (1995) Expression of costimulatory molecules B7–1 (CD80), B7–2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 182:1985–1996

    Article  Google Scholar 

  25. Pachter JS, de Vries HE, Fabry Z (2003) The blood–brain barrier and its role in immune privilege in the central nervous system. J Neuropathol Exp Neurol 62:593–604

    PubMed  CAS  Google Scholar 

  26. Labiche LA, Grotta JC (2004) Clinical trials for cytoprotection in Stroke. NeuroRx 1:46–70

    Article  PubMed  Google Scholar 

  27. Sharma HS, Ali SF (2008) Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury. Ann NY Acad Sci 1139:242–258

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania

    Dafin F. Muresanu

Authors
  1. Dafin F. Muresanu
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Research Center, PAN Warszawa, Ceglowska St. 80, Warszawa, 01-809, Poland

    Zbigniew Czernicki

  2. Klinikum Großhadern, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Alexander Baethmann

  3. Dept. Neurosurgery, Musashino Red Cross Hospital, Kyonan-cho 1-26-1, Musashino City, Tokyo, 180, Japan

    Umeo Ito

  4. School of Medicine, Nihon University, Oyaguchikami-machi 30-1 , Tokyo, 173-8610, Japan

    Yoichi Katayama

  5. Dept. Neuropathology, Medical Research Institute, Yushima 1-5-45, Tokyo, 113-8510, Japan

    Toshihiko Kuroiwa

  6. Dept. Neurosurgery, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE46BE, United Kingdom

    David Mendelow

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag/Wien

About this paper

Cite this paper

Muresanu, D.F. (2010). Neuromodulation with Pleiotropic and Multimodal Drugs – Future Approaches to Treatment of Neurological Disorders. In: Czernicki, Z., Baethmann, A., Ito, U., Katayama, Y., Kuroiwa, T., Mendelow, D. (eds) Brain Edema XIV. Acta Neurochirurgica Supplementum, vol 106. Springer, Vienna. https://doi.org/10.1007/978-3-211-98811-4_54

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-98811-4_54

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-98758-2

  • Online ISBN: 978-3-211-98811-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation