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Bone Metastases from Prostate Cancer pp 163–180Cite as

Bone Metastases from Prostate Cancer: Radiotherapy

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Abstract

Radiotherapy is an effective treatment in patients with prostate cancer and metastatic bone disease. It has been in use for about a century, since radium has been found efficacious in the treatment of cancer. At the end of the 1960s, with the growth of high-energy radiation units, modern techniques of external beam irradiation (external beam radiation therapy (EBRT)) started to be routinely used. In subsequent years, technological evolution enabled the development of highly sophisticated treatment techniques, evolving from two-dimensional (2D) radiotherapy to three-dimensional conformal radiation therapy (3D-CRT) and, in the last two decades, to intensity-modulated radiation therapy (IMRT). IMRT main benefit is linked to the possibility to modulate the fluence of the beams, allowing an optimal dose distribution and enabling to irradiate structures with highly irregular shape close to critical organs [1, 2]. More recently, with the development of volumetric-modulated arc therapy (VMAT), an additional advantage in target volume coverage and normal tissue sparing has been reached, with a reduced treatment delivery time compared with IMRT [3, 4]. These techniques concur to improve tumor control and to reduce toxicity in the surrounding healthy tissues.

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Authors and Affiliations

  1. Division of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, via G. Venezian 1, Milan, 20133, Italy

    Barbara Avuzzi & Riccardo Valdagni

  2. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Barbara Avuzzi & Riccardo Valdagni

  3. Department of Diagnostic Imaging and Radiotherapy, Università degli Studi di Milano, Milan, Italy

    Riccardo Valdagni

Authors
  1. Barbara Avuzzi
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  2. Riccardo Valdagni
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Correspondence to Barbara Avuzzi .

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Editors and Affiliations

  1. University of Verona, Director of Metabolic Bone Diseases and Osteoncology Unit, Internal Medicine Department of Medicine, Verona, Italy

    Francesco Bertoldo

  2. IRCCS AOU San Martino-IST National Cancer Research Institute, Department of Internal Medicine and Medical specialties (DIMI), School of Medical and Pharmacological Sciences, University of Genoa, Academic Unit of Medical Oncology, Department of Oncology (DIPOE), Genoa, Italy

    Francesco Boccardo

  3. Humanitas Gavazzeni Clinic, Clical Scientific Director Department of Nuclear Medicine, Bergamo, Italy

    Emilio Bombardieri

  4. Veneto Institute of Oncology IOV - IRCCS, Nuclear Medicine and Molecular imaging Unit, Padova, Italy

    Laura Evangelista

  5. Radiation Oncology 1 and Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Oncology and Hemato-oncology, Università di Milano, Milan, Italy

    Riccardo Valdagni

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Avuzzi, B., Valdagni, R. (2017). Bone Metastases from Prostate Cancer: Radiotherapy. In: Bertoldo, F., Boccardo, F., Bombardieri, E., Evangelista, L., Valdagni, R. (eds) Bone Metastases from Prostate Cancer . Springer, Cham. https://doi.org/10.1007/978-3-319-42327-2_14

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  • DOI: https://doi.org/10.1007/978-3-319-42327-2_14

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