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GeNeDis 2016 pp 249–259Cite as

Evaluating the Homeostasis Assessment Model Insulin Resistance and the Cardiac Autonomic System in Bariatric Surgery Patients: A Meta-Analysis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 988))

Abstract

Morbid obesity is a severe chronic disease and subject to surgical methods for losing weight. This intervention is expected to drive to better quality of life and health status. Other important aspects which may be influenced are: HOMA-IR (as insulin resistance marker) and heart rate variability (as cardiac function and autonomic nervous system marker), which are independent and valid predictors of future cardiac, neurological, metabolic health. We pooled 4 studies (646 subjects) resulting to HOMA-IR and nine HRV components-grouped in those undergone to gastric bypass (RYGP) and those operated with vertical sleeve gastrectomy (SG) method. We performed a meta-analysis in patients for HOMA-IR and HRV, using Hedge’s g correction of Cohen d for small samples. We concluded that RYGP favors insulin resistance decrease, whereas SG increases the vagal tone, improving cardiac function. The severity of cardiovascular diseases history suggests the selection of the surgery method: SG for the most severe cardiovascular cases and RYGP for those with higher HOMA-IR.

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Conflict of Interest

All authors see no conflict of interest.

Author information

Authors and Affiliations

  1. First Clinic of Paediatrics, Athens University, Aghia Sophia Children Hospital, Athens, Greece

    Styliani A. Geronikolou & George Chrousos

  2. Clinical, Translational, Experimental Surgery Research Center, Biomedical Research Foundation of Academy of Athens, 4 Soranou Efessiou Street, 11527, Athens, Greece

    Styliani A. Geronikolou

  3. First Department of Propedeutic Surgery, University of Athens, Hippokration Hospital, Athens, Greece

    Konstantinos Albanopoulos

  4. Clinical Translational, Experimental Surgery Research Centre, Biomedical Research Foundation Academy of Athens, 4 Soranou Efessiou Street, 11527, Athens, Greece

    George Chrousos & Dennis Cokkinos

Authors
  1. Styliani A. Geronikolou
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  2. Konstantinos Albanopoulos
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  3. George Chrousos
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  4. Dennis Cokkinos
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Corresponding author

Correspondence to Styliani A. Geronikolou .

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Editors and Affiliations

  1. Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Ionian University, Corfu, Greece

    Panayiotis Vlamos

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Geronikolou, S.A., Albanopoulos, K., Chrousos, G., Cokkinos, D. (2017). Evaluating the Homeostasis Assessment Model Insulin Resistance and the Cardiac Autonomic System in Bariatric Surgery Patients: A Meta-Analysis. In: Vlamos, P. (eds) GeNeDis 2016. Advances in Experimental Medicine and Biology, vol 988. Springer, Cham. https://doi.org/10.1007/978-3-319-56246-9_20

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