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Radionanomedicine pp 79–103Cite as

Graphene-Based Nanomaterials

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Graphenes are unique nanomaterials which was recently made compatible for physiological milieu, and thus find a way to be used as nanocarriers. The surface engineering abilities of nano-graphene oxides (nano-GOs) or graphene quantum dots (GQDs) in their own outstanding photoluminescence property have made it possible to be used for imaging or drug delivery. Though many successes were not reported in the application of GQDs in vivo, toxicity and safety of GOs in vitro and in vivo are being investigated. Interestingly, GOs are found to be degraded in vivo. In addition to much effort to use GOs as drug carriers, there have been recent trials to apply GOs for magnetic resonance imaging (MRI) and positron emission tomography (PET) or even multiplexed imaging with MRI/fluorescence or MRI/PET. The product has the composition of chelator-conjugated GOs loaded with iron oxide nanoparticles, and a variety of radionuclides such as 68Ga, 64Cu or 125I and 131I and 177Lu were used for PET or SPECT imaging and for radionuclide therapy, respectively. Multiplexed imaging or theranostics will enable targeted delivery, imaging in vivo with PET/SPECT and/or MRI and ex vivo confirmation of the tissues in preclinical studies.

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Authors and Affiliations

  1. Department of Chemistry, College of Natural Science, Seoul National University, Seoul, Republic of Korea

    Je Min Yoo & Byung Hee Hong

  2. Program in Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea

    Byung Hee Hong

  3. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Do Won Hwang

  4. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea

    Do Won Hwang

Authors
  1. Je Min Yoo
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  2. Do Won Hwang
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  3. Byung Hee Hong
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Correspondence to Byung Hee Hong .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Yoo, J.M., Hwang, D.W., Hong, B.H. (2018). Graphene-Based Nanomaterials. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_4

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