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Targeted Therapies in Cancer pp 61–80Cite as

Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 176))

Abstract

Colorectal cancer is one of the most frequent malignant tumors with a still increasing incidence in Western countries. Currently, colorectal cancer is the second most common cancer in Europe both in terms of incidence and mortality. Approximately 90% of all cancer deaths arise from the metastatic dissemination of primary tumors. Thus, metastasis is the most lethal attribute of colorectal cancer. Today, colorectal cancer and metastasis thereof are understood as the results of early changes during tumor progression that determine the metastasis capacity. Much is known about molecules contributing to the metastasis phenotype, the pathways they control, and the genes they regulate. However, patient prognosis is mainly defined by histopathological staging, a static description of the anatomical extent of tumor spread within a surgical specimen. This review demonstrates the need for and possibilities of molecular-based staging as an essential prerequisite for improved diagnosis, prognosis, and therapy. Molecular determinants for progression and metastasis of colorectal cancer are discussed representing both potential markers for metastasis prognosis and targets for intervention strategies aiming at the ultimate goal of metastasis prevention.

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Author information

Authors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125, Berlin, Germany

    Ulrike Stein PhD

  2. Robert Rössle Clinic, Charité Campus Buch, Lindenberger Weg 80, 13125, Berlin, Germany

    Peter M. Schlag MD

Authors
  1. Ulrike Stein PhD
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  2. Peter M. Schlag MD
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Editors and Affiliations

  1. Institut für Pathologie, Charité Humboldt-Universität zu Berlin, Schumanstr. 20-21, 10117, Berlin, Germany

    Manfred Dietel

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© 2007 Springer-Verlag Berlin Heidelberg

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Stein, U., Schlag, P.M. (2007). Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer. In: Dietel, M. (eds) Targeted Therapies in Cancer. Recent Results in Cancer Research, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46091-6_7

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  • DOI: https://doi.org/10.1007/978-3-540-46091-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

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