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Analysis and Imaging: PET

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Book cover Neutron Capture Therapy

Abstract

BNCT confers a tumoricidal effect that is heavily influenced not by the type of irradiation but by the biological distribution of boronated substrate injected into the body. Therefore, an important step in the planning for optimal BNCT for malignant tumor is to estimate the ratio of the boron concentration in tumor to surrounding normal tissue. One of the authors (KI) have first reported the radiosynthesis of the PET imaging probe [18F]FBPA and have confirmed its efficacy in estimating boron concentrations in animal experiments. A clinical PET application using [18F]FBPA have been started in clinical protocols in Japan for the selection of candidates for BNCT. Our comparative clinical imaging studies have revealed that [18F]FBPA PET images are almost identical to the images obtained with another amino acid probe, 11C methionine (MET). Static images of FBPA or MET-PET can be used for the planning of BNCT. PET imaging with amino acid probes may contribute significantly to the establishment of an appropriate BNCT application for patients with malignant tumors.

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Abbreviations

BNCT:

Boron neutron capture therapy

BPA:

4-boronophenylalanine

[18F]FBPA:

4-borono-2-[18F]fluorophenylalanine

FDG:

2-deoxy-2-[18F]fluoro-D-glucose

ICP-AES:

Inductively coupled plasma-atomic emission spectroscopy

MET:

l-[methyl-11C]methionine

PET:

Positron emission tomography

T/N :

Tumor-to-normal-tissue ratio

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Acknowledgement

We thank Dr. Kazuo Kubota from the Division of Nuclear Medicine in the Department of Radiology at the International Medical Center of Japan for kindly offering us whole-body PET images of MET uptake.

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Authors and Affiliations

  1. Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Tadashi Nariai

  2. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1, Nakacho, Itabashi-ku, Tokyo, 173-0011, Japan

    Kiichi Ishiwata

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  1. Tadashi Nariai
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  2. Kiichi Ishiwata
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Correspondence to Tadashi Nariai .

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Editors and Affiliations

  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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© 2012 Springer-Verlag Berlin Heidelberg

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Nariai, T., Ishiwata, K. (2012). Analysis and Imaging: PET. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-31334-9_11

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31333-2

  • Online ISBN: 978-3-642-31334-9

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