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Nutriomes and Personalised Nutrition for DNA Damage Prevention, Telomere Integrity Maintenance and Cancer Growth Control

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Advances in Nutrition and Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 159))

Abstract

DNA damage at the base sequence and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability, including telomere integrity and functionality and DNA repair. Using nutrient array systems with high-content analysis diagnostics of DNA damage, cell death and cell growth, it is possible to define, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. This knowledge can also be used to improve culture systems for cells used in therapeutics such as stem cells to ensure that they are not genetically aberrant when returned to the body. Furthermore, this information could be used to design dietary patterns that deliver the micronutrient combinations and concentrations required for preventing DNA damage by micronutrient deficiency or excess. Using this approach, new knowledge could be obtained to identify the dietary restrictions and/or supplementations required to control specific cancers, which is particularly important given that reliable validated advice is not yet available for those diagnosed with cancer.

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Abbreviations

MRI:

Magnetic resonance imaging

TRF1; TRF2:

Telomeric-repeat binding factors 1 and 2

MTHFR:

Methylenetetrahydrofolate reductase

ADH1:

Alcohol dehydrogenase

ALDH2:

Aldehyde dehydrogenase

CBMN Cyt:

Cytokinesis-blocked micronucleus cytome

MTAP:

Methylthioadenosine phosphorylase

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Authors and Affiliations

  1. CSIRO Food and Nutritional Sciences, 10041, Adelaide BC, SA, 5000, Australia

    Michael F. Fenech

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  1. Michael F. Fenech
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Correspondence to Michael F. Fenech .

Editor information

Editors and Affiliations

  1. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Vincenzo Zappia

  2. Clinical and Experimental Medicine, University of Naples "Federico II", Naples, Italy

    Salvatore Panico

  3. Institute of Food Sciences National Research Council, Avellino, Italy

    Gian Luigi Russo

  4. Dept. of Experimental Oncology, National Cancer Institute, Naples, Italy

    Alfredo Budillon

  5. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Fulvio Della Ragione

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Fenech, M.F. (2014). Nutriomes and Personalised Nutrition for DNA Damage Prevention, Telomere Integrity Maintenance and Cancer Growth Control. In: Zappia, V., Panico, S., Russo, G., Budillon, A., Della Ragione, F. (eds) Advances in Nutrition and Cancer. Cancer Treatment and Research, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38007-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-38007-5_24

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