Skip to main content

Radiation-Induced Injury of the Central Nervous System

  • Chapter

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Radiation therapy, since its introduction into clinical use, has played an integral part in the treatment and management of various intacranial benign and malignant tumors, and many studies have proven its efficacy. Initially, the central nervous system (CNS) was considered to be relatively radioresis-tant, but early reports from the 1940s describing severe damage of normal brain tissue and the spinal cord revealed the limited tolerance of the CNS to ionizing radiation (Boden 1948; Greenfield and Stark 1948).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albo V, Miller D, Leiken S (1985) Nine brain tumors as a late effect in children “cured” of acute lymphoblastic leukemia from a single pool study (abstract). Proc Am Soc Clin Oncol 4: 172

    Google Scholar 

  • Al-Mefty O, Kersh JE, Routh A, Smith RR (1990) The long-term side effects of radiation therapy for benign brain tumors in adults. J Neurosurg 73: 502

    Article  PubMed  CAS  Google Scholar 

  • Ang KK, van der Kogel AJ, van der Schueren E (1985) Lack of evidence for increased tolerance of rat spinal cord with decreasing fraction doses below 2 Gy. Int J Radiat Oncol Biol Phys 11: 105

    Article  PubMed  CAS  Google Scholar 

  • Asai A, Matsutani M, Kohno T, Nakanira O, Tanaka H, Fujimaki T, Funada N, Matsuda T, Nagata K, Takura K (1989) Subacute brain atrophy after radiation for malignant brain tumors. Cancer 63: 1962

    Article  PubMed  CAS  Google Scholar 

  • Berg RA, Ch’ien LT, Lancaster W, Wiliams S, Cummins J (1983) Neuropsychological sequelae of postradiation somnolence syndrome. Dev Behav Pediatr 4: 103

    Article  CAS  Google Scholar 

  • Bleyer WA (1988) Hobson’s choice in the CNS radioprophy-laxis of small cell lung cancer. Int J Radiat Oncol Biol Phys 15:783

    Article  PubMed  CAS  Google Scholar 

  • Boden G (1948) Radiation myelitis of the cervical spinal cord. Br J Radiol 21:464

    Article  PubMed  CAS  Google Scholar 

  • Burger PC, Mahaly MS Jr, Dudka L, Vogel FS (1979) The morphologic effects of radiation administered therapeuti-cally for intracranial gliomas. Cancer 44: 1256

    Article  PubMed  CAS  Google Scholar 

  • Cecchetti E, Brandoli V (1979) Cranial irradiation in children with lymphoblastic acute leukemia: results and damages. Int J Radiat Oncol Biol Phys 5: 367

    Article  PubMed  CAS  Google Scholar 

  • Chak LY, Zatz LM, Wasserstein P, Cox RS, Kushlan PD, Porzig KJ, Sicic BI (1986) Neurologic dysfunction in patients treated for small cell carcinoma of the lung: a clinical and radiological study. Int J Radiat Oncol Biol Phys 12: 385

    Article  PubMed  CAS  Google Scholar 

  • Constine LS, Konski A, Ekholm S, McDonald S, Rubin P (1988) Adverse effects of brain irradiation correlated with MR and CT imaging. Int J Radiat Oncol Biol Phys 15:319

    Article  PubMed  CAS  Google Scholar 

  • De Angelis L (1991) Radiation induced central and peripheral nervous system complications. In: Poswer FB, Foley MK, Malkin MG, Callaway M (eds) Neuroonco-logy IV: recent developments in the management of neuro-oncological illnesses. Syllabus (postgraduate course). Memorial Sloane-Kettering Cancer Center, New York

    Google Scholar 

  • Devinsky O (1991) Radiation-induced tumors of the central and peripheral nervous system. In: Rottenberg DA (ed) Neurological complications of cancer treatment. Butter-worth-Heinemann, Boston, p 79

    Google Scholar 

  • Dropcho EJ (1991) Central nervous system injury by therapeutic irradiation. Neurol Clin 9: 969

    PubMed  CAS  Google Scholar 

  • Fike JR, Sheline GE, Cann CE, Davis RL (1984) Radiation necrosis. Prog Exp Tumor Res 28: 136

    PubMed  CAS  Google Scholar 

  • Fike JR, Cann CE, Turowsky K, Higgins RJ, Chan AS, Phillips TL, Davis RL (1988) Radiation dose response of normal brain. Int J Radiat Oncol Biol Phys 14: 63

    Article  PubMed  CAS  Google Scholar 

  • Foo SH, Hiesinger E, Wise A (1986) Quality of long-term survival of treated patients with malignant glioma (abstract). Proc Am Soc Clin Oncol 5: 136

    Google Scholar 

  • Greenfield MM, Stark FM (1948) Post-radiation neuropathy. AJR 60: 617

    CAS  Google Scholar 

  • Hochberg FH, Slotnik B (1980) Neuropsychologic impairment in astrocytoma survivors. Neurology 30: 172

    PubMed  CAS  Google Scholar 

  • Imperato JP, Paleologos NA, Vick NA (1990) Effects of treatment on long-term survivors with malignant as-trocytomas. Ann Neurol 28: 818

    Article  PubMed  CAS  Google Scholar 

  • Johnson BE, Becker B, Goff WB, Petronas N, Krehbiel MA, Makuch RW, McKenna G, Glatstein E, Ihde DC (1985) Neurologic, neuropsychologic and computed tomography scan abnormalities in 2-to 10-years survivors of small-cell lung cancer. J Clin Oncol 3: 1659

    PubMed  CAS  Google Scholar 

  • Kramer S (1968) The hazards of therapeutic irradiation of the central nervous system. Clin Neurosurgery 15: 301

    CAS  Google Scholar 

  • Kramer JH, Norman D, Brant-Zawatzki M, Ablin A, Moore IM (1988) Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis for leukemia. Cancer 61: 928

    Article  PubMed  CAS  Google Scholar 

  • Leibel SA, Sheline GE (1990) Radiotherapy in the cerebral astrocytomas. In: Thomas DGD (ed) Neuro-oncology: primary malignant brain tumors. Arnold, London, p 193

    Google Scholar 

  • Leibel SA, Sheline GE (1991) Tolerance of the brain and spinal cord to conventional irradiation. In: Gutin PH, Leibel SA, Sheline GE (eds) Radiation injury to the nervous system. Raven, New York, p 239

    Google Scholar 

  • Littman P, Rosenstock J, Gale G, Krisch RE, Meadows A, Sather H, Coccia P, DeCamargo B (1984) The somnolence syndrome in leukemic children following reduced daily dose fractions of cranial irradiation. Int J Radiat Oncol Biol Phys 10: 1851

    Article  PubMed  CAS  Google Scholar 

  • Maire JP, Coudin B, Guerin J, Caudry M (1987) Neuro-psychological impairment in adults with brain tumors. Am J Clin Oncol 10: 156

    Article  PubMed  CAS  Google Scholar 

  • Mandybur TI, Gore I (1969) Amyloid in late postirradiation necrosis of brain. Neurology 19: 983

    PubMed  CAS  Google Scholar 

  • Manz HJ, Woolley PV III, Ornitz RD (1979) Delayed radiation necrosis of brainstem related to fast neutron beam irradiation. Cancer 44: 473

    Article  PubMed  CAS  Google Scholar 

  • Marks JE, Baglan RJ, Prassad SC, Blank WF (1981) Cerebral radionecrosis: Incidence and risk in relation to dose, time, fractionation and volume. Int J Radiat Oncol Biol Phys 7: 243

    Article  PubMed  CAS  Google Scholar 

  • Martins AN, Johnston JS, Henry JM, Stoffel TJ, DiChiro G (1977) Delayed radiation necrosis of the brain. J Neurosurgery 47: 336

    Article  CAS  Google Scholar 

  • Meadows AT, Massari DJ, Fergusson J, Gordon J, Littman P, Moss K (1981) Declines in IQ scores and cognitive dysfunction in children with acute lymphcytic leukemia treated with cranial irradiation. Lancet 7: 1015

    Article  Google Scholar 

  • Muchi H, Satoh T, Yamamoto K, Karube T, Miyao M (1987) Studies on the assessment of neurotoxicity in children with acute lymphoblastic leukemia. Cancer 59: 891

    Article  PubMed  CAS  Google Scholar 

  • Parker D, Malpas JS, Sandland R, Sheaff PC, Freeman JE, Paxton A (1978) Outlook following “somnolence syndrome” after prophylactic cranial irradiation. Br J Med 4: 554

    Article  Google Scholar 

  • Pezner RD, Archambeau JO (1981) Brain tolerance unit: a method to estimate risk of radiation brain injury for various dose schedules. Int J Radiat Oncol Biol Phys 7: 397

    Article  PubMed  CAS  Google Scholar 

  • Rubin P (1977) Radiation toxicology: quantitative radiation pathology for predicting effects. Cancer 39 [Suppl]: 739

    Article  Google Scholar 

  • Rubinstein AB, Shalit MN, Cohen ML, Zandbank U, Reichenthal E (1984) Radiation-induced cerebral menin-gioma: a recognizable entity. J Neurosurg 61: 966

    Article  PubMed  CAS  Google Scholar 

  • Salvati M, Artico M, Caruso R, Rocchi G, Orlando ER, Nucci F (1991) A report on radiation-induced gliomas. Cancer 67: 392

    Article  PubMed  CAS  Google Scholar 

  • Seiler RW (1980) Late results of multimodality therapy of high-grade supratentorial astrocytomas. Surg Neurol 15: 88

    Article  Google Scholar 

  • Shapiro S, Mealey J, Sartorius C (1989) Radiation-induced intracranial malignant gliomas. J Neurosurg 71: 77

    Article  PubMed  CAS  Google Scholar 

  • Sheline GE, Wara WM, Smith V (1980) Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6: 1215

    Article  PubMed  CAS  Google Scholar 

  • Soffer D, Pittaluga S, Feiner M, Beler AJ (1983) Intracranial meningiomas following low-dose irradiation to the head. J Neurosurg 59: 1048

    Article  PubMed  CAS  Google Scholar 

  • Stylopoulos LA, George AE, de Leon MJ, Miller JD, Foo SH, Hiesiger E, Wise A (1988) Longitudinal study of parenchymal brain changes in glioma survivors. AJNR 9: 517

    PubMed  CAS  Google Scholar 

  • van der Kogel AJ (1986) Radiation-induced damage in the central nervous system: An interpretation of target cell responses. Br J Cancer (suppl.) 53: 207

    Google Scholar 

  • van der Kogel AJ (1991) Clinical implications of radiological studies on CNS tolerance. In: Karim ABMF, Laws ER (eds) Glioma. Springer, Berlin Heidelberg New York, p 179

    Chapter  Google Scholar 

  • Wara WM, Phillips TL, Sheline GE, Schwade JG (1975) Radiation tolerance of the spinal cord. Cancer 35: 1558

    Article  PubMed  CAS  Google Scholar 

  • Wigg DR, Koschel K, Hodgson GS (1981) Tolerance of the mature human central nervous system to photon irradiation. Br J Radiol 54: 787

    Article  PubMed  CAS  Google Scholar 

  • Yoshii Y, Phillips TL (1992) Late vascular effect of whole brain x-irradiation in the mouse. Acta Neurochir (Wien) 64:87

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Müller, RP. (1995). Radiation-Induced Injury of the Central Nervous System. In: Dunst, J., Sauer, R. (eds) Late Sequelae in Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46794-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46794-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46796-7

  • Online ISBN: 978-3-642-46794-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics