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Pore-Forming Toxins pp 53–83Cite as

Staphylococcal Pore-Forming Toxins

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 257))

Abstract

Together with Pseudomonas aeruginosa and Escherichia coli, Staphylococcus aureus (S. aureus) is the most frequently isolated bacteria in routine hospital testing. Like the two other pathogens, S. aureus may synthesize numerous virulence factors, develop multiple resistances to antibiotics, and be responsible for numerous no-socomial infections. Within the repertoire of toxins secreted by the bacteria, the pore-forming toxins constitute, similar to the superantigens, a large family of compounds with comparable, though distinct, functions, effects and structures. The lytic effect of these pore-forming toxins has been known for about 100 years (van der Velde 1894). Some of these toxins may be produced by almost all the strains, while others are produced only by a few. The latter group can be investigated for clinical association with diseases. Several related toxins may be genetically maintained and secreted by a single strain. Therefore, it is of interest to understand why these related toxins are conserved, what benefit they provide to the bacteria and what is their contribution to pathogenesis. The role and the mode of action of these toxins have been assessed in a variety of experimental models.

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Authors and Affiliations

  1. Institut de Bactériologie de la Faculté de Médecine, Université Louis Pasteur-Hôpitaux Universitaires de Strasbourg, 3, rue Koeberlé, 67000, Strasbourg, France

    G. Prévost & D. A. Colin

  2. Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS, 205, route de Narbonne, 31077, Toulouse Cedex, France

    L. Mourey

  3. Centro Fisica Stati Aggregati, CNR-ITC, Via Sommarive 18, 38050, Povo (Trento), Italy

    G. Menestrina

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  1. G. Prévost
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  4. G. Menestrina
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  1. Departement de Biochimie Sciences II, Quai Ernest-Ansermet, 1211, Genéve 4, Switzerland

    F. Gisou van der Goot

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Prévost, G., Mourey, L., Colin, D.A., Menestrina, G. (2001). Staphylococcal Pore-Forming Toxins. In: van der Goot, F.G. (eds) Pore-Forming Toxins. Current Topics in Microbiology and Immunology, vol 257. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56508-3_4

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