Skip to main content
SpringerLink
Log in
Book cover

Hantaviruses pp 117–134Cite as

Clinical Manifestations of New World Hantaviruses

  • Chapter

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 256))

Abstract

In May 1993 a new clinical entity named hantavirus pulmonary syndrome (HPS) was first described in the United States during the investigation of an outbreak of a febrile disease of high mortality, characterized by acute respiratory insufficiency (Duchin et al. 1994). HPS was found to be caused by a novel agent of the Hantavirus genus, Sin Nombre virus (SNV; Nichol et al. 1993; Ksiazek et al. 1995). Since the discovery of the disease, isolated cases and outbreaks of HPS have been registered all over the Americas, and other SNV-related hantaviruses (New World hantaviruses) were identified either causing human illnesses or circulating among native sigmodontine rodent species.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Briggiler A, Levis S, Pini N, Riera L, Enria D (1998) Presentación clínica de las infecciones por hantavirus en el area central de Argentina. Medicina (Buenos Aires) 52(5/2):673

    Google Scholar 

  • Bryan RT, Doyle TJ, Moolenaar RL, Pflieger AK, Khan AS, Ksiazek TG, Peters CJ (1997) Hantavirus pulmonary syndrome. Semin Pediatr Infect Dis 8:44–49

    Article  Google Scholar 

  • Centers for Disease Control and Prevention (1997) Case definitions for infectious conditions under public health surveillance. Morbid Mortal Weekly Rep 46(RR-10):16

    Google Scholar 

  • Chapman LE, Mertz G, Khan AS, Hart DC, Peters CJ, Koster E, Ksiazek TG, Rollin PE, Wilson L, Baum KF, Pavia AT, Christerson JC, Allen S, Rubin PJ, Goad D, Ribavirin Study Group (1994) Open label intravenous ribavirin for hantavirus pulmonary syndrome. Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, abstr. H-lll. American Society for Microbiology, Washington DC; 1994

    Google Scholar 

  • Colavecchia S, Martinez P, Miguel S, Edelstein A, González Delia Valle M, Trincheri A, Marone J, Adala R, Verzeri L, Segura E, Rabinovich D, Padula P (1999) Distributión y variabilidad genética de los virus causantes de Síndrome Pulmonar por Hantaviurus (SPH) en la provincia de Buenos Aires. VI Congreso Argentino de Virología, Buenos Aires, 29–31 de Agosto de 1999. Abstract 153, p 61

    Google Scholar 

  • Cortés J, Cacace ML, Seijo A, Parisi MN, Ayala LT (1994) Distress respiratorio del adulto en Orán, Salta. Presented in the 11er Simposio International de Infectología Pediátrica, Córdoba, Argentina, 7–11 May 1994

    Google Scholar 

  • Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Ksiazek TG, Rollin PE, Nichol S, Umland ET, Moolenaar RL, Reef SE, Nolte KR, Gallaher MM, Butler JC, Breiman RF, Hantavirus Study Group (1994) Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. N Engl J Med 330:949–955

    Article  PubMed  CAS  Google Scholar 

  • Enria DA (1998) Emergencia de los Hantavirus en las Americas y en la Argentina. Medicina (Buenos Aires) 58(1): 13–18

    Google Scholar 

  • Enria DA, Padula P, Segura EL, Pini N, Edelstein A, Riva Posse C, Weissenbacher MC (1996) Hantavirus pulmonary syndrome in Argentina: possibility of person-to-person transmission. Medicina (Buenos Aires) 58:709–711

    Google Scholar 

  • Ferrer JF, Jonsson C, Esteban N, Galligan D, Bosombrio MA, Peralta-Ramos M, Bharadwaj M, Torres-Martinez N, Callahan J, Segovia A, Hjelle B (1998) Epidemiological features of SNV-related hantavirus infection in high prevalence Gran Chaco Indian populations. Abstracts of the fourth International Conference on HFRS and Hantaviruses, p. 144

    Google Scholar 

  • Hallin GW, Simpson SQ, Crowell RE, James DS, Koster FT, Mertz GJ, Levy H (1996) Cardiopulmonary manifestations of hantavirus pulmonary syndrome. Crit Care Med 24:252–258

    Article  PubMed  CAS  Google Scholar 

  • Huggins JW, Hsiang CM, Cosgriff TM, Guang MY, Smith JI, Wu ZO, Le Duc JW, Zheng ZM, Meegan JM, Wang QN, Oland DD, Gui WE, Gibbs PH, Yuan GH, Zhang TM (1991) Prospective, doubleblind,concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis 164:1119–1127

    Article  PubMed  CAS  Google Scholar 

  • Iversson LB, Travassos da Rosa APA, Rosa MDB, Lomar AV, Sasaki MDGM, LeDuc JW (1994) Human infection by Hantavirus in southern and southeastern Brazil. Rev Ass Med Brasil 40(2):85–92

    CAS  Google Scholar 

  • Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST (1997) Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238:115–127

    Article  PubMed  CAS  Google Scholar 

  • Ketai LH, Williamson MR, Telepak RJ, Levy H, Koster FT, Nolte KB, Allen SE (1994) Hantavirus pulmonary syndrome: radiographic findings in 16 patients. Radiology 191(3):665–668

    PubMed  CAS  Google Scholar 

  • Khan AS, Spiropoulou CS, Morzunov S, Zaki SR, Kohn MA, Nawas SR, Mc Farland L, Nichol ST (1995) A fatal illness associated with a new hantavirus in Louisiana. J Med Virol 46:281–286

    Article  PubMed  CAS  Google Scholar 

  • Khan AS, Gaviria M, Rollin PE, Hlady WG, Ksiazek TG, Armstrong LR, Greenman R, Ravkov E,Kolber M, Anapol H, Sfakianaki ED, Nichol ST, Peters CJ, Khabbaz RF (1996a) Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus.Am J Med 100:46–48

    Article  PubMed  CAS  Google Scholar 

  • Khan AS, Khabbaz RF, Armstrong LR, Holman RC, Bauer SP, Graber J, Strine T, Miller G, Reef S,Tappero J, Rollin PE, Nichol ST, Zaki SR, Bryan RT, Chapman LE, Peters CJ, Ksiazek TG (1996b) Hantavirus pulmonary syndrome: the first 100 US cases. J Infect Dis 173:1297–1303

    Article  PubMed  CAS  Google Scholar 

  • Kitsutani PT, Denton RW, Fritz CL, Murray RA, Todd RL, Pape WJ, Frampton JW, Young JC, Khan AS, Peters CJ, Ksiazek TG (1999) Acute Sin Nombre Hantavirus infection without pulmonary syndrome, United States. Emerg Infect Dis 5(5):701–705

    Article  PubMed  CAS  Google Scholar 

  • Koster F, Levy H (1998) Clinical manifestations and treatment of HPS. In: Ho Wang Lee, Charles Calisher, Connie Schmajhon (eds) Manual of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome - WHO Collaborating Center for Virus Reference and Research (Hantaviruses).Asan Institute for life Sciences, Seoul

    Google Scholar 

  • Ksiazek TG, Peters CJ, Rollin PE, Zaki S, Nichol S, Spiropoulou C, Morzunov S, Feldmann H, Sanchez A, Khan AS, Mahy BWJ, Wachsmuth K, Butler JC (1995) Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52:117–123

    PubMed  CAS  Google Scholar 

  • Lázaro M, Resa A, Barclay C, Calanni L, Lasala M, Padula P, Pini N, Enria D (2000) Síndrome pulmonar por hantavirus en el sur andino argentino. Accepted for publication - Medicina (Buenos Aires)

    Google Scholar 

  • LeDuc J, Smith GA, Pinheiro FP, Vasconcelos P, Rosa E, Maiztegui JI (1985) Isolation of a Hantaanrelated virus from Brazilian rats and serologic evidence of its widespread distribution in South America. Am J Trop Med Hyg 34:810–815

    PubMed  CAS  Google Scholar 

  • LeDuc J, Smith GA, Childs JE, Pinheiro FP, Maiztegui JI, Niklasson B, Antoniadis A, Robinson DM,Khin M, Shortridge KE, Wooster MT, Elwell MR, liberty PLT, Koech D, Rosa EST, Rosen L (1986) Global survey of antibody to Hantaan-related viruses among peridomestic rodents. Bull WHO 64 pp 139-144

    Google Scholar 

  • Levis SC, Briggiler AM, Cacase M, Peters CJ, Ksiazek TG, Cortes J, Lázaro ME, Resa A, Rollin PE,Pinheiro FP, Enria DA (1995) Emergence of hantavirus pulmonary syndrome in Argentina. Am J Trop Med Hyg (Sup) 53(2):233

    Google Scholar 

  • Levis S, Morzunov S, Rowe J, Enria D, Pini N, Calderon G, Sabattini M, St. Jeor S (1998) Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177:529–538

    Article  PubMed  CAS  Google Scholar 

  • Lopez N, Padula P, Rossi C, Lazaro ME, Franze-Fernandez MT (1996) Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220:223–226

    Article  PubMed  CAS  Google Scholar 

  • Lopez N, Padula P, Rossi C, Miguel S, Edelstein A, Ramirez E, Franze-Fernández MT (1997) Genetic characterization and phylogeny of Andes virus and variants from Argentina and Chile. Virus Res 50:77–84

    Article  PubMed  CAS  Google Scholar 

  • Maiztegui JI, Becker JL, LeDuc JW (1983) Actividad del virus de la fiebre hemorrágica de Corea o virus muroide en ratas del puerto de la ciudad de Buenos Aires. Medicina (Buenos Aires) 43:871

    Google Scholar 

  • Mansilla C, Tapia M, Nolte K, Barclay C, Samengo L, Feddersen R, Hjelle B (1997) Pathological findings and distribution of viral antigens in tissues of patients with fatal Andes hantavirus infection.Am J Trop Med Hyg 57(3):45

    Google Scholar 

  • Moolenaar RL, Dalton C, Lipman HB, Umland ET, Gallaher M, Duchin JS, Chapman L, Zaki SR, Ksiazek TG, Rollin PE, Nichol ST, Cheek JE, Butler JC, Breiman RF (1995) Clinical features that differentiate hantavirus pulmonary syndrome from three other acute respiratory illnesses. Clin Infect Dis 21:643–649

    Article  PubMed  CAS  Google Scholar 

  • Nichol S, Spiropoulou C, Morzunov S, Rollin P, Ksiazek TG, Feldmann H, Sanchez A, Childs G, Zaki S, Peters CJ (1993) Genetic identification of a Hantavirus associated with an outbreak of acute respiratory illness. Science 262:914–917

    Article  PubMed  CAS  Google Scholar 

  • Padula P, Edelstein A, Miguel SDL, Lopez NM, Rossi CM, Rabinovich RD (1998) Hantavirus pulmonary syndrome (HPS) outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241:323–330

    Article  PubMed  CAS  Google Scholar 

  • Pan American Health Organization (1999) Hantavirus in the Americas: guidelines for diagnosis, treatment, prevention, and control. Pan American Health Organization, Washington DC

    Google Scholar 

  • Parisi MN, Enria DA, Pini NC, Sabattini MS (1996) Retrospective detection of clinical infections caused by hantavirus in Argentina. Medicina (Buenos Aires) 56(1): 1–13

    Google Scholar 

  • Peters CJ (1998) In: Sheld WM, Craig WA, Hughes JM (eds) Hantavirus pulmonary syndrome in the Americas. Emerging Infections 2. ASM Press, Washington DC, pp 17-64

    Google Scholar 

  • Pini N, Resa A, Laime G, Lecot G, Ksiazek T, Levis S, Enria D (1998) Hantavirus infection in children in Argentina. Emerg Infect Dis 4:85–87

    Article  PubMed  CAS  Google Scholar 

  • Pini N, Cacase M, Ubeid C, Trincheri A, Resa A, Peretti D, Bolpe J, Bogni L, Briggiler A, Ksiazek T, Levis S (1999) Pautas para el estudio serológico de contactos de Síndrome Pulmonar por Hantavirus (SPH). VI Congreso Argentina de Virología, Buenos Aires, 29–31 de agosto de 1999. Abstract 082 pp 62

    Google Scholar 

  • Schmaljohn C, Hjelle B (1997) Hantaviruses: a global disease problem. Emerg Infect Dis 3:95–104

    Article  PubMed  CAS  Google Scholar 

  • Simpson SQ, Levy H (1999) Hantaviruses. In: Raphael Polin, Peter F Wright, Marcel Dekker (eds) Viral Infections of the Respiratory tract. Inc pp 281-306

    Google Scholar 

  • Toro J, Vega J, Khan A, Mills J, Padula P, Terry W, Yadón Z, Valderrama R, Ellis B, Pavletic C, Cerda R, Zaki S, Wun-Ju S, Meyer R, Tapia M, Mansilla C, Baro M, Vergara J, Concha M, Calderón G, Enria D, Peters CJ, Ksiazek T (1998) An outbreak of hantavirus pulmonary syndrome, Chile 1997. Emerg Infect Dis Vol 4(4):687–694, Oct-Dec 1998

    Article  PubMed  CAS  Google Scholar 

  • Valderrama R, Vega J, Terry W (1998) Community serological survey of infection by hantavirus in the XI region, Aysen, Chile. Abstracts of the Fourth International Conference on HFRS and Hantaviruses p 155

    Google Scholar 

  • Weissenbacher M, Merani MS, Hodara VL, et al. (1990) Hantavirus infection in laboratory and wild rodents in Argentina. Medicina (Buenos Aires) 50:43–46

    CAS  Google Scholar 

  • Weissenbacher M, Cura E, Segura EL, et al. (1996) Serological evidence of human hantavirus infection in Argentina, Bolivia and Uruguay. Medicina (Buenos Aires) 56:17–22

    CAS  Google Scholar 

  • Wells RM, Young J, Williams RJ, Armstrong LR, Busico K, Khan AS, Ksiazek TG, Rollin PE, Zaki SR, Nichol ST, Peters CJ (1997a) Hantavirus transmission in the United States. Emerg Infect Dis 3: 361–365

    Article  PubMed  CAS  Google Scholar 

  • Wells RM, Sosa Stani S, Yadón Z, Enria D, Padula P, Pini N, Mills JN, Peters CJ, Segura EL, Hantavirus Pulmonary Syndrome Group for Patagonia (1997b) An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Emerg Infect Dis 3:171–174

    Article  PubMed  CAS  Google Scholar 

  • Wells RM, Sosa Estani S, Yadón Z, Enria D, Padula P, Pini N, González Delia Valle M, Mills J, Peters CJ (1998) Seroprevalence of antibodies to Hantavirus in health care workers and other residents of Southern Argentina. Clin Infect Dis, pp 27-28

    Google Scholar 

  • Williams RJ, Bryan RT, Mills JN, Palma RE, Vera I, Velásquez F, Baez EM, Schmidt WE, Figueroa RE, Peters CJ, Zaki SR, Khan AS, Ksiazek TG (1997) An outbreak of hantavirus pulmonary syndrome in western Paraguay. Am J Trop Med Hyg 57:274–282

    PubMed  CAS  Google Scholar 

  • Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumwalt RE, Miller GL, Khan AS, Rollin PE, Ksiazek TG, Nichol ST, Mahi BWJ, Peters CJ (1995) Hantavirus Pulmonary Syndrome. Pathogenesis of an Emerging Infectious Disease. Am J Pathol 146:552–579

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio I. Maiztegui” (INEVH), ANLIS, Monteagudo 2510, 2700, Pergamino, Argentina

    D. A. Enria, A. M. Briggiler, N. Pini & S. Levis

Authors
  1. D. A. Enria
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Briggiler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Pini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Levis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Molecular Virology, Virology Division, USAMRIID, 1425 Porter Street, Ft. Detrick, Frederick, MD, 21702-5011, USA

    Connie S. Schmaljohn Ph.D.

  2. Molecular Biology Section, Special Pathogens Branch, Division of Viral and Rickettsial Disease, Centers for Disease Control and Prevention (CDC), Atlanta, GA, 30333, USA

    Stuart T. Nichol Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Enria, D.A., Briggiler, A.M., Pini, N., Levis, S. (2001). Clinical Manifestations of New World Hantaviruses. In: Schmaljohn, C.S., Nichol, S.T. (eds) Hantaviruses. Current Topics in Microbiology and Immunology, vol 256. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56753-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56753-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62491-9

  • Online ISBN: 978-3-642-56753-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation