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Hepatocyte Growth Factor Secreted by Human Liver Myofibroblasts Increases Invasiveness of Hepatocellular Carcinoma Cells

  • Chapter
Book cover Tissue Repair and Fibrosis

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 93))

Abstract

Hepatocellular carcinoma (HCC) is one of the most frequent primary tumors in the world. It is a major complication of liver cirrhosis, although more rarely it will develop on a non-cirrhotic liver. Like many cancers, HCC is infiltrated by myofibroblast (MF)-like cells. They can be identified through their positive staining for smooth muscle α-actin. Their phenotype is very similar to that of MFs, which are the major source of fibrosis components in chronic liver diseases [6, 7, 27]. Interactions between tumor cells and mesenchymal cells have been demonstrated in several models of cancer. For example, the growth of several tumors in nude mice was markedly enhanced if fibroblasts were co-injected with tumor cells [8, 14]. Also, tumor-associated MFs have been shown to be involved in the in vivo and in vitro invasiveness of colon-cancer cell lines [5].

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Abbreviations

HCC:

hepatocellular carcinoma

MF:

myofibroblast

HGF:

hepatocyte growth factor

DMEM:

Dulbecco’s modified Eagle medium

CM:

conditioned medium

EGF:

epidermal growth factor

SDS-PAGE:

sodium dodecyl sulfate/polyacrylamide gel electrophoresis

cDNA:

complementary deoxyribonucleic acid

ELISA:

enzyme-linked immunosorbent assay

IgG:

immunoglobulin G

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Authors
  1. V. Neaud
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  2. S. Faouzi
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  3. J. Guirouilh
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  4. A. Monvoisin
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  5. J. Rosenbaum
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Editor information

Editors and Affiliations

  1. GREF, Université Victor Segalen Bordeaux 2, 146, Rue Léo-Saignat, 33076, Bordeaux Cedex, France

    Alexis Desmoulière

  2. Départment de Nutrition, Université de Montréal, Pavillon Liliane-de-Stewart C. P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada

    Beatriz Tuchweber

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© 1999 Springer-Verlag Berlin Heidelberg

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Neaud, V., Faouzi, S., Guirouilh, J., Monvoisin, A., Rosenbaum, J. (1999). Hepatocyte Growth Factor Secreted by Human Liver Myofibroblasts Increases Invasiveness of Hepatocellular Carcinoma Cells. In: Desmoulière, A., Tuchweber, B. (eds) Tissue Repair and Fibrosis. Current Topics in Pathology, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58456-5_20

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  • DOI: https://doi.org/10.1007/978-3-642-58456-5_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63603-5

  • Online ISBN: 978-3-642-58456-5

  • eBook Packages: Springer Book Archive

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