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Epidemiologie der Demenzen

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Zusammenfassung

Zum Ende des 20. Jahrhunderts hat die Zahl der über 65jährigen in Deutschland knapp 13 Millionen erreicht. Nach konservativer Schätzung ist bis zur Mitte des nächsten Jahrhunderts bei überproportionaler Zunahme der Höchstbetagten ein anhaltendes Wachstum der Altenbevölkerung um wenigstens weitere vier Millionen Menschen zu erwarten. Zu den wichtigsten medizinischen, sozialen und ökonomischen Problemen, die durch den demographischen Wandel aufgeworfen wurden, zählt die Versorgung der hohen und fortgesetzt steigenden Zahl von Demenzerkrankungen. Der folgende Beitrag schildert, wie häufig Demenzen nach den Resultaten epidemiologischer Studien sind und wie sie sich in der Bevölkerung verteilen, stellt einige der Auswirkungen auf das Versorgungssystem dar und faßt den Kenntnisstand über Risikofaktoren der Alzheimer Demenz (AD) als numerisch bedeutsamster Demenzform zusammen.

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Literatur

  • Aevarsson O, Skoog I (1996) A population-based study on the incidence of dementia disorders between 85 and 88 years of age. JAGS 44: 1455–1460

    CAS  Google Scholar 

  • Aevarsson O, Svanborg A, Skoog I (1998) Seven-year survival rate after age 85 years. Relation to Alzheimer disease and vascular dementia. Arch Neurol 55: 1226–1232

    Article  PubMed  CAS  Google Scholar 

  • Agüero -Torres H, Fratiglioni L, Guo Z, Viitanen M, von Strauss E, Winblad B (1998) Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study. AJPH 88: 1452–1456

    Article  Google Scholar 

  • Andersen K, Launer LJ, Ott A, Hoes AW, Breteler MMB, Hofman A (1995) Do nonsteroidal antiinflammatory drugs decrease the risk for Alzheimer’s disease?Neurology 45: 1441–1445

    PubMed  CAS  Google Scholar 

  • Bachman DL, Wolf PA, Linn RT (1993) Incidence of dementia and probable Alzheimer’s disease in a general population: The Framingham study. Neurology 43: 515–519

    PubMed  CAS  Google Scholar 

  • Baidereschi M, Di Carlo A, Lepore V (1998) Estrogen-replacement therapy and Alzheimer’s disease in the Italian Longitudinal Study on Aging. Neurology 50: 996–1002

    Google Scholar 

  • Beard CM, Kokmen E, O’Brien PC, Kurland LT(1994) Are patients with Alzheimer’s disease surviving loriger in recent years?Neurology 44: 1869–1871

    PubMed  CAS  Google Scholar 

  • Bickel H (1995) Demenzkranke in Alten- und Pflegeheimen: Gegenwärtige Situation und Entwicklungstendenzen. In: Forschungsinstitut der Friedrich-Ebert-Stiftung (Hrsg) Medizinische und gesellschaftspolitische Herausforderung: Alzheimer Krankheit. Der langsame Zerfall der Persönlichkeit. Friedrich-Ebert-Stiftung, Bonn, pp 49–68

    Google Scholar 

  • Bickel H (1996) Pflegebedürftigkeit im Alter. Ergebnisse einer populationsbezogenen retrospektiven Längsschnittstudie. Gesund -Wes 58, Sonderheft 1: 56–62

    Google Scholar 

  • Bickel H, Cooper B (1994) Incidence and relative risk of dementia in an urban elderly population: findings of a prospective field study. Psychol Med 24: 179–192

    Article  PubMed  CAS  Google Scholar 

  • Boothby H, Blizard R, Livingston G, Mann AH (1994) The Gospel Oak Study stage III: the incidence of dementia. Psychol Med 24: 89–95

    Article  PubMed  CAS  Google Scholar 

  • Breteler MMB, de Groot RRM, van Romunde LKJ, Hofman A (1995) Risk of dementia in patients with Parkinson’s disease, epilepsy, and severe head trauma: a register-based follow-up study. Am J Epidemiol 142: 1300–1305

    PubMed  CAS  Google Scholar 

  • Buntinx F, Kester A, Bergers J, Knottnerus JA (1996) Is depression in elderly people followed by dementia? A retrospective cohort study based in general practice. Age Ageing 25: 231–233

    Article  PubMed  CAS  Google Scholar 

  • Butler SM, Ashford JW, Snowdon DA (1996) Age, education, and changes in the Mini-Mental State Exam scores of older wornen: findings from the Nun Study. JAGS 44: 675–681

    CAS  Google Scholar 

  • Canadian Study of Health and Aging (1994) The Canadian Study of Health and Aging: Risk factors for Alzheimer’s disease in Canada. Neurology 44: 2073–2080

    Google Scholar 

  • Canadian Study of Health and Aging Working Group (1994) Canadian Study of Health and Aging: study methods and prevalence of dementia. Can Med Assoc J 150: 899–913

    Google Scholar 

  • Chandra V, Ganguli M, Pandav R, Johnston J, Belle S, De Kosky ST (1998) Prevalence of Alzheimer’s disease and other dementias in rural India. The Indo-US study. Neurology 51: 1000–1008

    PubMed  CAS  Google Scholar 

  • Chiu HFK, Lam LCW, Chi (1998) Prevalence of dementia in Chinese elderly in Hong Kong. Neurology 50: 1002–1009

    PubMed  CAS  Google Scholar 

  • Christensen H, Korten AE, Jorm AF, Henderson AS, Jacomb PA, Rodgers B (1997) Education and decline in cognitive Performance: compensatory but not protective. Int J Geriat Psychiatry 12: 323–330

    Article  CAS  Google Scholar 

  • Cobb JL, Wolf PA, Au R, White R, D’Agostino RB(1995) The effect of education on the incidence of dementia and Alzheimer’s disease in the Frainingham Study. Neurology 45: 1707–1712

    PubMed  CAS  Google Scholar 

  • Cooper B, Bickel H, Schäufele M(1992) Demenzerkrankungen und leichtere kognitive Beeinträchtigungen bei älteren Patienten in der ärztlichen Allgemeinpraxis. Ergebnisse einer Querschnittuntersuchung. Nervenarzt 63: 551–560

    PubMed  CAS  Google Scholar 

  • Cooper B, Bickel H, Schäufele M(1996) Early development and progression of dementing illness in the elderly: a general-practice based study. Psychol Med 26: 411–419

    Article  PubMed  CAS  Google Scholar 

  • Cooper B, Sosna U (1983) Psychische Erkrankung in der Altenbevölkerung: eine epidemiologische Feldstudie in Mannheim. Nervenarzt 54: 239–249

    PubMed  CAS  Google Scholar 

  • Dartigues JF, Commenges D, Letenneur L (1997) Cognitive predictors of dementia in elderly Community residents. Neuroepidemiology 16: 29–39

    Article  PubMed  CAS  Google Scholar 

  • Dartigues JF, Gagnon M, Letenneur L (1992) Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid). Am J Epidemiol 135: 981–988

    PubMed  CAS  Google Scholar 

  • Devanand DP, Sano M, Tang MX (1996) Depressed mood and the incidence of Alzheimer’s disease in the elderly living in the Community. Arch Gen Psychiatry 53: 175–182

    PubMed  CAS  Google Scholar 

  • Dufouil C, Fuhrer R, Dartigues JF, Alperovitch A (1996) Longitudinal analysis of the association between depressive symptomatology and cognitive deterioration. Am J Epidemiol 144: 634–641

    PubMed  CAS  Google Scholar 

  • Ebly EM, Parhad IM, Hogan DB, Fung TS (1994) Prevalence and types of dementia in the very old: Results from the Canadian Study of Health and Aging. Neurology 44: 1593–1600

    PubMed  CAS  Google Scholar 

  • Erkinjuntti T, Ostbye T, Steenhuis R, Hachinski V (1997) The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med 337: 1667–1674

    Article  PubMed  CAS  Google Scholar 

  • Ernst RL, Hay JW (1994) The US economic and social costs of Alzheimer’s disease revisited. AJPH 84: 1261–1264

    Article  CAS  Google Scholar 

  • Ernst RL, Hay JW, Fenn C, Tinklenberg J, Yesavage JA (1997) Cognitive function and the costs of Alzheimer disease. Arch Neurol 54: 687–693

    PubMed  CAS  Google Scholar 

  • Evans DA, Hebert LE, Beckett LA (1997) Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol 54: 1399–1405

    PubMed  CAS  Google Scholar 

  • Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P (1995) Social and leisure activities and risk of dementia: a prospective longitudinal study. JAGS 43: 485–490

    CAS  Google Scholar 

  • Fichter MM, Meiler I, Schröppel H, Steinkirchner R(1995) Dementia and cognitive impairment in the oldest old in the Community. Prevalence and comorbidity. Brit J Psychiat 166: 621–629

    Article  PubMed  CAS  Google Scholar 

  • Fichter MM, Schröppel H, Meiler I(1996) Incidence of dementia in a Munich Community sample of the oldest old. Eur Arch Psychiatry Clin Neurosei 246: 320–328

    Article  CAS  Google Scholar 

  • Forbes WF, Hill GB (1998) Is exposure to aluminum a risk factor for the development of Alzheimer disease?Yes. Arch Neurol 55: 740–741

    Article  PubMed  CAS  Google Scholar 

  • Ford AB, Mefrouche Z, Friedland RP, Debanne SM (1996) Smoking and cognitive impairment: A population-based study. JAGS 44: 905–909

    CAS  Google Scholar 

  • Forette F, Seux ML, Staessen JA et al. (1998) Prevention of dementia in randomised double-blind placebocontrolled Systolic Hypertension in Europe (Sysr-Eur) trial. Lancet 352: 1347–1351

    Article  PubMed  CAS  Google Scholar 

  • Forster DP, Newens AJ, Kay DWK, Edwardson JA (1995) Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England. J Epidemiology Community Health 49: 253–258

    Article  CAS  Google Scholar 

  • Fourrier A, Letenneur L, Begaud B, Dartigues JF (1996) Nonsteroidal antiinflammatory drug use and cognitive function in the elderly: Inconclusive results from a population-based cohort study. J Clin Epidemiol 49: 1201

    Article  PubMed  CAS  Google Scholar 

  • Fratiglioni L, Ahlbom A, Viitanen M, Winblad B (1993) Risk factors for late-onset Alzheimers disease: A population-based, case-control study. Ann Neurol 33: 258–266

    Article  PubMed  CAS  Google Scholar 

  • Fratiglioni L, Forseil Y, Torres HA, Winblad B(1994) Severity of dementia and institutionalization in the elderly: prevalence data from an urban area in Sweden. Neuroepidemiology 13: 79–88

    Article  PubMed  CAS  Google Scholar 

  • Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B (1997) Very old women at highest risk of dementia and Alzheimer’s disease: Incidence data from the Kungsholmen Project, Stockholm. Neurology 48: 132–138

    PubMed  CAS  Google Scholar 

  • Galanis DJ, Petrovitch H, Launer LJ, Harris TB, Foley DJ, White LR (1997) Smoking history on middle age and subsequent cognitive Performance in elderly Japanese-American men. The Honolulu-Asia Aging Study. Am J Epidemiol 145: 507–515

    PubMed  CAS  Google Scholar 

  • Ganguli M, Mendelsohn A, Lytle M, Dodge H (1998) A follow-up comparison of study participants and refusers within a rural elderly population. J Gerontol 53A: M465–M470

    Google Scholar 

  • Gao S, Hendrie HC, Hall KS, Hui S (1998) The relationships between age, sex, and the incidence of dementia and Alzheimer disease. Arch Gen Psychiatry 55: 809–815

    Article  PubMed  CAS  Google Scholar 

  • Graham JE, Rockwood K, Beattie BL et al. (1997) Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 349: 1793–1796

    Article  PubMed  CAS  Google Scholar 

  • Graves AB, Larson EB, Edland SD et al. (1996) Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington State. Am J Epidemiol 144: 760–771

    PubMed  CAS  Google Scholar 

  • Graves AB, van Duijn CM, Chandra V et al. (1991) Alcohol and tobacco consumption as risk factors for Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiology 20, Suppl. 2: 48–57

    Google Scholar 

  • Gray A, Fenn P (1993) Alzheimer’s disease: the bürden of the illness in England. Health Trends 25: 31–37

    PubMed  CAS  Google Scholar 

  • Guo Z, Viitanen M, Fratiglioni L, Winblad B (1997) Blood pressure and dementia in the elderly: epidemiologie perspectives. Biomed & Pharmacother 51: 68–73

    Article  CAS  Google Scholar 

  • Hagnell O, Lanke J, Rorsman B, Öjesjö L(1981) Does the incidence of age psychosis decrease? A prospective, longitudinal study of a complete population investigated during the 25-year period 1947-1972: the Lundby study. Neuropsychobiology 7: 201–211

    Article  PubMed  CAS  Google Scholar 

  • Hänninen T, Koivisto K, Reinikainen KJ et al. (1996) Prevalence of ageing-associated cognitive decline in an elderly population. Age Ageing 25: 201–205

    Article  PubMed  Google Scholar 

  • Harrison R, Savla N, Kafetz K (1990) Dementia, depression and physical disability in a London borough: a survey of elderly people in and out of residential care and implications for future developments. Age Ageing 19: 97–103

    Article  PubMed  CAS  Google Scholar 

  • Haupt M, Kurz A (1993) Predictors of nursing home placement in patients with Alzheimer’s disease. Int J Geriat Psychiatry 8: 741–746

    Article  Google Scholar 

  • Hebert LE, Scherr PA, Beckett LA et al. (1992) Relation of smoking and alcohol consumption to ineident Alzheimer’s disease. Am J Epidemiol 135: 347–355

    PubMed  CAS  Google Scholar 

  • Hebert LE, Scherr PA, Beckett LA et al. (1993) Relation of smoking and low-to-moderate alcohol consumption to change in cognitive function: a longitudinal study in a defined Community of older persons. Am J Epidemiol 137: 881–891

    Google Scholar 

  • Hebert LE, Scherr PA, Beckett LA et al. (1995) Age-specific incidence of Alzheimer’s disease in a Community population. JAMA 273: 1354–1359

    Article  PubMed  CAS  Google Scholar 

  • Hèbert R, Brayne C, Spiegelhalter D (1997) Incidence of functional decline and improvement in a community-dwelling, very elderly population. Am J Epidemiol 145: 935–944

    PubMed  Google Scholar 

  • Heeren TJ, van Hemert AM, Rooymans HGM (1992) A community-based study of survival in dementia. Acta Psychiatr Scand 85: 415–418

    Article  PubMed  CAS  Google Scholar 

  • Henderson AS, Jorm AF, Christensen H, Jacomb PA, Korten AE (1997) Aspirin, anti-inflammatory drugs and risk of dementia. Int J Geriat Psychiatry 12: 926–930

    Article  CAS  Google Scholar 

  • Hendrie HC, Osuntokun BO, Hall KS et al. (1995) Prevalence of Alzheimer’s disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry 152: 1485–1492

    PubMed  CAS  Google Scholar 

  • Heyman A, Peterson B, Fillenbaum G, Pieper C (1997) Predictors of time to institutionalization of patients with Alzheimer’s disease: The CERAD experience, Part XVII. Neurology 48: 1304–1309

    PubMed  CAS  Google Scholar 

  • Hofman A, Ott A, Breteler MMB et al. (1997) Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer’s disease in the Rotterdam Study. Lancet 349: 151–154

    Article  PubMed  CAS  Google Scholar 

  • Hofman A, Rocca WA, Brayne C et al. (1991) The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int J Epidemiology 20: 736–748

    Article  CAS  Google Scholar 

  • Jacobs DM, Tang MX, Stern Y et al. (1998) Cognitive function in nondemented older women who took estrogen after menopause. Neurology 50: 368–373

    PubMed  CAS  Google Scholar 

  • Jama JW, Launer LJ, Witteman JCM et al. (1996) Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study. Am J Epidemiol 144: 275–280

    PubMed  CAS  Google Scholar 

  • Johansson B, Zarit SH (1995) Prevalence and incidence of dementia in the oldest old: a longitudinal study of a population-based sample of 84-90-year-olds in Sweden. Int J Geriat Psychiatry 10: 359–366

    Article  Google Scholar 

  • Jorm AF, Jolley D (1998) The incidence of dementia. A meta-analysis.Neurology 51: 728–733

    PubMed  CAS  Google Scholar 

  • Jorm AF, Korten AE, Henderson AS (1987) The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatr Scand 76: 465–479

    Article  PubMed  CAS  Google Scholar 

  • Jorrn AF, van Duijn CM, Chandra V et al. (1991) Psychiatric history and related exposures as risk factors for Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiology 20, Suppl. 2: 43–47

    Google Scholar 

  • Juva K, Sulkava R, Erkinjuntti T, Valvanne J, Tilvis R (1993) Prevalence of dementia in the city of Helsinki. Acta Psychiatr Scand 87: 106–110

    CAS  Google Scholar 

  • Kalmijn S, Feskens EJM, Launer LJ, Kromhout D (1997) Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 145: 33–41

    PubMed  CAS  Google Scholar 

  • Kalmijn S, Feskens EJM, Launer U, Kromhout D (1996) Cerebrovascular disease, the apolipoprotein s4 allele, and cognitive decline in a community-based study of elderly men. Stroke 27: 2230–2235

    Article  PubMed  CAS  Google Scholar 

  • Kalmijn S, Launer LJ, Ott A, Witteman JCM, Hofman A, Breteler MMB (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Arm Neurol 42: 776–782

    Article  CAS  Google Scholar 

  • Katzman R (1976) The prevalence and malignancy of Alzheimer disease. A major killer. Arch Neurol 33: 217–218

    CAS  Google Scholar 

  • Katzman R, Aronson M, Fuld P et al. (1989) Development of dementing illness in an 80-year-old volunteer cohort. Ann Neurol 25: 317–324

    Article  PubMed  CAS  Google Scholar 

  • Katzman R, Hill LR, Yu ESH et al. (1994) The malignancy of dementia. Predictors of mortality in clinically diagnosed dementia in a population survey of Shanghai, China. Arch Neurol 51: 1220–1225

    PubMed  CAS  Google Scholar 

  • Kawas C, Resnick S, Morrison A et al. (1997) A prospective study of estrogen replacement therapy and the risk of developing Alzheimer’s disease: The Baltimore Longitudinal Study of Aging. Neurology 48: 1517–1521

    PubMed  CAS  Google Scholar 

  • Kihara T, Shimohama S, Sawada H et al. (1997) Nicotinic receptor Stimulation protects neurons against ß-amyloid toxicity. Ann Neurol 42: 159–163

    Article  PubMed  CAS  Google Scholar 

  • Knapp M, Wilkinson D, Wigglesworth R (1998) The economic consequences of Alzheimer’s disease in the context of new drug developments. Int J Geriat Psychiatry 13: 531–543

    Article  CAS  Google Scholar 

  • Kokmen E, Beard CM, O’Brien PC, Offord KP, Kurland LT(1993) Is the incidence of dementing illness changing?A 25-year time trend study in Rochester, Minnesota (1960-1984). Neurology 43: 1887–1892

    PubMed  CAS  Google Scholar 

  • Kokmen E, Beard MC, Offord KP, Kurland LT (1989) Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, January 1, 1975. Neurology 39: 773–776

    PubMed  CAS  Google Scholar 

  • Kukull WA, Larson EB, Bowen JD et al. (1995) Solvent exposure as a risk factor for Alzheimer’s disease: a case-control study. Am J Epidemiol 141: 1059–1071

    PubMed  CAS  Google Scholar 

  • Launer LJ, Feskens EJM, Kalmijn S, Kromhout D (1996) Smoking, drinking, and thinking. The Zutphen Elderly Study. Am J Epidemiol 143: 219–227

    PubMed  CAS  Google Scholar 

  • Launer LJ, Masaki K, Petrovitch H, Foley D, Havlik RJ (1995) The association between midlife blood pressure levels and late-life cognitive function. The Honululu-Asia Aging Study. JAMA 274: 1846–1851

    Article  PubMed  CAS  Google Scholar 

  • Lee PN (1994) Smoking and Alzheimer’s disease: A review of the epidemiological evidence. Neuroepidemiology 13: 131–144

    Article  PubMed  Google Scholar 

  • Leibson CL, Rocca WA, Hanson VA et al. (1997) Risk of dementia among persons mith diabetes mellitus: a population-based cohort study. Am J Epidemiol 145: 301–308

    PubMed  CAS  Google Scholar 

  • Letenneur L, Commenges D, Dartigues JF, Barberger-Gateau P (1994) Incidence of dementia and Alzheimer’s disease in elderly Community residents of south-western France. Int J Epidemiology 23: 1256–1261

    Article  CAS  Google Scholar 

  • Lindsay J, Hebert R, Rockwood K (1997) The Canadian Study of Health and Aging. Risk factors for vascular dementia. Stroke 28: 526–530

    Article  PubMed  CAS  Google Scholar 

  • Liu CK, Lai CL, Tai CT, Lin RT, Howng SL (1998) Incidence and subtypes of dementia in southern Taiwan: impact of socio-demographic factors. Neurology 50: 1572–1579

    PubMed  CAS  Google Scholar 

  • MantonKG, Stallard E (1991) Cross-sectional estimates of active life expectancy for the U.S. elderly and oldest-old populations. J Gerontol 46: 170–182

    Google Scholar 

  • Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF (1997) Aluminum concentrations in drinking water and risk of Alzheitner’s disease. Epidemiology 8: 281–286

    Article  PubMed  CAS  Google Scholar 

  • Mayeux R, Ottman R, Maestre G et al. (1995) Synergistic effects of traumatic head injury and apolipoprotein epsilon 4 in patients with Alzheimers disease. Neurology 45: 555–557

    PubMed  CAS  Google Scholar 

  • Mayeux R, Ottman R, Tang MX et al. (1993) Genetic susceptibility and head injury as risk factors for Alzheimer’s disease among community-dwelling elderly persons and their first-degree relatives. Ann Neurol 33: 494–501

    Article  PubMed  CAS  Google Scholar 

  • McGeer PL, Schulzer M, McGeer EG (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheinter’s disease: A review of 17 epidemiologic studies. Neurology 47: 425–432

    PubMed  CAS  Google Scholar 

  • Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (1998) Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. Psychol Med 28: 319–335

    Article  Google Scholar 

  • Meiler I, Fichter, M Schröppel H (1996) Verlauf und verlaufsbeeinflussende Faktoren bei dementiellen und depressiven Erkrankungen bei sehr alten Menschen: eine epidemiologische Untersuchung. Abschlußbericht an das Bundesministerium für Bildung, Forschung und Wissenschaft. (UnPub)

    Google Scholar 

  • Mendelsohn AB, Belle SH, Stoehr GP, Ganguli M (1998) Use of antioxidant supplements and ist association with cognitive function in a rural elderly cohort. The Movies Project. Am J Epidemiol 148: 38–44

    PubMed  CAS  Google Scholar 

  • Mölsä PK, Marttila RJ, Rinne UK (1982) Epidemiology of dementia in a Finnish population. Acta Neurol Scand 541-552

    Google Scholar 

  • Mortimer JA, van Duijn CM, Chandra V et al. (1991) Head trauma as a risk factor for Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiology 20, Suppl. 2: 28–35

    Google Scholar 

  • Munoz DG (1998) Is exposure to aluminum a risk factor for the development of Alzheimer disease?- No. Arch Neurol 55: 737–739

    Article  PubMed  CAS  Google Scholar 

  • Newens AJ, Forster DP, Kay DWK, Kirkup W, Bates D, Edwardson J (1993) Clinically diagnosed presenile dementia of the Alzheimer type in the Northern Health Region: ascertaininent, prevalence, incidence and survival. Psychol Med 23: 631–644

    Article  PubMed  CAS  Google Scholar 

  • Notkola IL, Sulkava R, Pekkanen J et al. (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer’s disease. Neuro epidemiology 17: 14–20

    CAS  Google Scholar 

  • O’Donnell BF, Drachman DA, Barnes HJ, Peterson KE, Swearer JM, Lew RA (1992) Incontinence and troublesome behaviors predict institutionalization in dementia. J Geriatrie Psych and Neurol 5: 45–52

    Google Scholar 

  • O’Meara ES, Kukull WA, Sheppard L et al. (1997) Head injury and risk of Alzheimer’s disease by apolipoprotein E genotype. Am J Epidemiol 146: 373–384

    PubMed  Google Scholar 

  • O’Connor DW, Pollitt PA, Hyde JB et al. (1989) The prevalence of dementia as measured by the Cambridge Mental Disorders of the Elderly Examination. Acta Psychiatr Scand 79: 190–198

    Article  PubMed  Google Scholar 

  • O’Connor DW, Pollitt PA, Hyde JB, Fellowes JL, Miller ND, Roth M (1991) The progression of mild idiopathic dementia in a Community population. JAGS 39: 246–251

    Google Scholar 

  • Orgogozo JM, Dartigues JF, Lafont S et al. (1997) Wine consumption and dementia in the elderly: a prospective Community study in the Bordeaux area. Rev Neurol (Paris) 153: 185–192

    CAS  Google Scholar 

  • Ostbye T, Crosse E (1994) Net economic costs of dementia in Canada. Can Med Assoc J 151: 1457–1464

    CAS  Google Scholar 

  • Ott A, Breteler MMB, de Bruyne MC, van Harskamp F, Grobbee DE, Hofman A (1997) Atrial fibrillation and dementia in a population-based study. The Rotterdam Study. Stroke 28: 316–321

    Article  PubMed  CAS  Google Scholar 

  • Ott A, Breteler MMB, van Harskamp F et al. (1995) Prevalence of Alzheimer’s disease and vascular dementia: association with education. The Rotterdam study. British Med J 310: 970–973

    Article  CAS  Google Scholar 

  • Ott A, Breteler MMB, van Harskamp F, Stijnen T, Hofman A (1998) Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 147: 574–580

    PubMed  CAS  Google Scholar 

  • Ott A, Slooter AJC, Hofman A et al. (1998) Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort study: the Rotterdam Study. Lancet 351: 1840–1843

    Article  PubMed  CAS  Google Scholar 

  • Paykel ES, Brayne C, Huppert FA et al. (1994) Incidence of dementia in a population older than 75 years in the United Kingdom. Arch Gen Psychiatry 51: 325–332

    PubMed  CAS  Google Scholar 

  • Perenboom RJM, Boshuizen HC, Breteler MMB, Ott A, van de Water PA (1996) Dementia-free life expectancy (DemFLE) in The Netherlands. Soc Sei Med 43: 1703–1707

    Article  CAS  Google Scholar 

  • Prince M, Rabe-Hesketh S, Brennan P (1998) Do antiarthritic drugs decrease the risk for cognitive decline? An analysis based on data from the MRC Treatment Trial of Hypertension in Older Adults. Neurology 50: 374–379

    PubMed  CAS  Google Scholar 

  • Prince MJ, Bird AS, Blizard RA, Mann AH (1996) Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council’s treatment trial of hypertension in older adults. British Med J 312: 801–805

    Article  CAS  Google Scholar 

  • Rajkumar S, Kumar S, Thara R (1997) Prevalence of dementia in a rural setting: a report ftom India. Int J Geriat Psychiatry 12: 702–707

    Article  CAS  Google Scholar 

  • Rasmusson DX, Brandt J, Martin DB, Folstein MF (1995) Head injury as a risk factor in Alzheimer’s disease. Brain Injury 9: 213–219

    Article  PubMed  CAS  Google Scholar 

  • Rice DP, Fox PJ, Max W et al. (1993) The economic bürden of Alzheimer’s disease care. Health Affairs 12: 164–176

    Article  PubMed  CAS  Google Scholar 

  • Rifat SL, Eastwood MR, Mclachlan DRC, Corey PN (1990) Effect of exposure of miners to aluminium powder. Lancet 336: 1162–1165

    Article  PubMed  CAS  Google Scholar 

  • Ritchie K, Kildea D (1995) Is senile dementia “age-related” or “ageing-related”? - Evidence from metaanalysis of dementia prevalence in the oldest old. Lancet 346: 931–934

    Article  PubMed  CAS  Google Scholar 

  • Ritchie K, Leibovici D, Ledesert B, Touchon J (1996) A typology of sub-clinical senescent cognitive disorder. Brit J Psychiat 168: 470–476

    Article  PubMed  CAS  Google Scholar 

  • Ritchie K, Robine JM, Letenneur L, Dartigues JF (1994) Dementia-free life expectancy in France. AJPH 84: 232–236

    Article  CAS  Google Scholar 

  • Roberts GW, Allsop D, Bruton C (1990) The occult aftermath of boxing. Journal of Neurology, Neurosurgery, and Psychiatry 53: 373–378

    Article  PubMed  CAS  Google Scholar 

  • Rocca WA, Cha RH, Waring SC, Kokmen E (1998) Incidence of dementia and Alzheimer’s disease: a reanalysis of data frorn Rochester, Minnesota, 1975-1984. Am J Epidemiol 148: 51–62

    PubMed  CAS  Google Scholar 

  • Roelands M, van Oyen H, Baro F (1994) Dementia-free life expectancy in Belgium. Eur J Pub Health 4: 33–37

    Article  Google Scholar 

  • Rovner BW, German PS, Broadhead J et al. 1990) The prevalence and management of dementia and other Psychiatric disorders in nursing homes. International Psychogeriatrics 2: 13–24

    Article  PubMed  CAS  Google Scholar 

  • Rozzini R, Ferrucci L, Losonczy K, Havlik RJ, Guralnik JM (1996) Protective effect of chronic NSAID use on cognitive decline in older persons. JAGS 44: 1025–1029

    CAS  Google Scholar 

  • SaagKG, Rubenstein LM, Chrischilles EA, Wallace RB (1995) Nonsteroidal antiinflammatory drugs and cognitive decline in the elderly. J Rheumatol 22: 2142–2147

    PubMed  CAS  Google Scholar 

  • Salib E, Hillier V (1997) Head injury and the risk of Alzheimer’s disease: a case-control study. Int J Geriat Psychiatry 12: 363–368

    Article  CAS  Google Scholar 

  • Saunders PA, Copeland JRM, Dewey ME et al. (1991) Heavy drinking as a risk factor for depression and dementia in elderly men. Findings from the Liverpool longitudinal Community study. Brit J Psychiat 159:213–216

    Article  PubMed  CAS  Google Scholar 

  • Schmand B, Smit J, Lindeboorn J et al. (1997) Low education is a genuine risk factor for accelerated memory decline and dementia. J Clin Epidemiol 50: 1025–1033

    Article  PubMed  CAS  Google Scholar 

  • Schofield PW, Tang M, Marder K et al (1997) Alzheimer’s disease after remote head injury: an incidence study. Journal of Neurology, Neurosurgery, and Psychiatry 62: 119–124

    Article  PubMed  CAS  Google Scholar 

  • Schulte PA, Burnett CA, Boeniger MF, Johnson J (1996) Neurodegenerative diseases: Occupational occurrence and potential risk factors, 1982 through 1991. Am J Public Health 86: 1281–1288

    Article  PubMed  CAS  Google Scholar 

  • Severson MA, Smith GE, Tangalos EG et al. (1994) Patterns and predictors of institutionalization in community-based dementia patients. JAGS 42: 181–185

    CAS  Google Scholar 

  • Shaji S, Promodu K, Abraham T, Roy KJ, Verghese A (1996) An epidemiological study of dementia in a rural Community in Kerala, India. Brit J Psychiat 168: 745–749

    Article  CAS  Google Scholar 

  • Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K (1998) Cholesterol depletion inhibits the generation of ß-amyloid in hippocampal neurons. Proc Natl Acad Sei 95: 6460–6464

    Article  CAS  Google Scholar 

  • Skoog I, Hesse C, Aevarsson O et al. (1998) A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality. Journal of Neurology, Neurosurgery, and Psychiatry 64: 37–43

    Article  PubMed  CAS  Google Scholar 

  • Skoog I, Lernfeit B, Landahl S et al. (1996) 15-year longitudinal study of blood pressure and dementia. Lancet 347: 1141–1145

    Article  PubMed  CAS  Google Scholar 

  • Slooter AJC, Tang MX, van Duijn CM et al. (1997) Apolipoprotein E 84 and the risk of dementia with stroke. A population-based investigation. JAMA 277: 818–821

    Article  PubMed  CAS  Google Scholar 

  • Small BJ, Viitanen M, Bäckman L (1997) Mini-Mental State Examination item scores as predictors of Alzheimer’s disease: incidence data from the Kungsholmen Project, Stockholm. J Gerontol 52A: M299–M304

    Google Scholar 

  • Sobel E, Dunn M, Davanipour Z, Qian Z, Chui HC (1996) Elevated risk of Alzheimer’s disease among workers with likely electromagnetic field exposure. Neurology 47: 1477–1481

    PubMed  CAS  Google Scholar 

  • Sobel E, Louhija J, Sulkava R et al. (1995) Lack of association of apolipoprotein E allele E4 with late-onset Alzheimer’s disease among Finnish centenarians. Neurology 45: 903–907

    PubMed  CAS  Google Scholar 

  • Speck CE, Kukull WA, Brenner DE et al. (1995) History of depression as a risk factor for Alzheimer’s disease. Epidemiology 6: 366–369

    Article  PubMed  CAS  Google Scholar 

  • Statistisches Bundesamt (1997) Statistisches Jahrbuch 1997 für die Bundesrepublik Deutschland. Metzler Poeschel, Wiesbaden

    Google Scholar 

  • Stern Y, Alexander GE, Prohovnik I, Mayeux R (1992) Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer’s disease. Ann Neurol 32: 371–375

    Article  PubMed  CAS  Google Scholar 

  • Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R (1994) Influence of education and occupation on the ineidence of Alzheimer’s disease. JAMA 271: 1004–1010

    Article  PubMed  CAS  Google Scholar 

  • Stern Y, Tang MX, Albert MS et al. (1997) Predicting time to nursing home eare and death in individuals with Alzheimer disease. JAMA 277: 806–812

    Article  PubMed  CAS  Google Scholar 

  • Stern Y, Tang MX, Denaro J, Mayeux R (1995) Inereased risk of mortality in Alzheimer’s disease patients with more advanced educational and occupational attainment. Ann Neurol 37: 590–595

    Article  PubMed  CAS  Google Scholar 

  • Stewart R (1998) Cardiovascular factors in Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry 65: 143–147

    Article  PubMed  CAS  Google Scholar 

  • Stewart WF, Kawas C, Corrada M, Metter EJ (1997) Risk of Alzheimer’s disease and duration of NSAID use. Neurology 48: 626–632

    PubMed  CAS  Google Scholar 

  • Stommel M, Collins CE, Given BA (1994) The costs of family contributions to the care of persons with dementia. Gerontologist 34: 199–205

    Article  PubMed  CAS  Google Scholar 

  • Swan GE, DeCarli C, Miller BL et al. 1998) Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology 51: 986–993

    PubMed  CAS  Google Scholar 

  • Tyas SL (1996) Are tobacco and alcohol use related to Alzheimer’s disease? A critical assessment of the evidence and its implications. Addiction Biology 1: 237–254

    Article  PubMed  CAS  Google Scholar 

  • van Duijn CM, Stijnen T, Hofman A(1991) Risk factors for Alzheimer’s disease: Overview of the EURODEM collaborative re-analysis of case-control studies. Int J Epidemiology 20, Suppl. 2: 4–12

    Google Scholar 

  • Weinberger M, Gold DT, Divine GW et al. (1995) Expenditures in caring for patients with dementia who live at home. Am J Public Health 83: 338–341

    Article  Google Scholar 

  • Welch HG, Walsh JS, Larson EB (1992) The cost of institutional care in Alzheimer’s disease: nursing home and hospital use in a prospective cohort. JAGS 40: 221–224

    CAS  Google Scholar 

  • Wernicke TF, Reischies FM (1994) Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older. Neurology 44: 250–253

    PubMed  CAS  Google Scholar 

  • White L, Katzman R, Losonczy K et al. (1994) Association of education with incidence of cognitive impairment in three established populations for epidemiologic studies of the elderly. J Clin Epidemiol 47: 363–374

    Article  PubMed  CAS  Google Scholar 

  • Winblad B, Ljunggren G, Karlsson G, Wimo A (1996) What are the costs to society and to individuals regarding diagnostic procedures and care of patients with dementia? Acta Neurol Scand Suppl. 168: 101–104

    Article  PubMed  CAS  Google Scholar 

  • Yaffe K, Sawaya G, Lieberburg I, Grady D (1998) Estrogen therapy in postmenopausal women. Effects on cognitive function and dementia. JAMA 279: 688–695

    Article  PubMed  CAS  Google Scholar 

  • Yoshitake T, Kiyohara Y, Kato I et al. (1995) Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population: The Hisayama study. Neurology 45: 1161–1168

    PubMed  CAS  Google Scholar 

  • Zhang M, Katzman R, Salmon D et al. (1990) The prevalence of dementia and Alzheimer’s disease in Shanghai, China: impact of age, gender, and education. Ann Neurol 27: 428–437

    Article  PubMed  CAS  Google Scholar 

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Bickel, H. (1999). Epidemiologie der Demenzen. In: Förstl, H., Bickel, H., Kurz, A. (eds) Alzheimer Demenz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60228-3_2

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