3. Das Konzept der Pollen-Panallergene: Profiline und Polcalcine

Zurück zum Zitat Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro M, Barber D (2014) Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy 69:1610–1616CrossRefPubMed Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro M, Barber D (2014) Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy 69:1610–1616CrossRefPubMed

Zurück zum Zitat Assarehzadegan MA, Amini A, Sankian M, Tehrani M, Jabbari F, Varasteh A (2010) Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins. Biosci Biotechnol Biochem 74:1441–1446CrossRefPubMed Assarehzadegan MA, Amini A, Sankian M, Tehrani M, Jabbari F, Varasteh A (2010) Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins. Biosci Biotechnol Biochem 74:1441–1446CrossRefPubMed

Zurück zum Zitat Asturias JA, Ibarrola I, Fernandez J, Arilla MC, Gonzalez-Rioja R, Martinez A (2005) Pho d 2, a major allergen from date palm pollen, is a profilin: cloning, sequencing, and immunoglobulin E cross-reactivity with other profilins. Clin Exp Allergy 35:374–381CrossRefPubMed Asturias JA, Ibarrola I, Fernandez J, Arilla MC, Gonzalez-Rioja R, Martinez A (2005) Pho d 2, a major allergen from date palm pollen, is a profilin: cloning, sequencing, and immunoglobulin E cross-reactivity with other profilins. Clin Exp Allergy 35:374–381CrossRefPubMed

Zurück zum Zitat Balla T (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev 93:1019–1137PubMedCentralCrossRefPubMed Balla T (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev 93:1019–1137PubMedCentralCrossRefPubMed

Zurück zum Zitat Ballmer-Weber BK, Hoffmann A, Wuthrich B, Luttkopf D, Pompei C, Wangorsch A, Kastner M, Vieths S (2002) Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 57:228–235CrossRefPubMed Ballmer-Weber BK, Hoffmann A, Wuthrich B, Luttkopf D, Pompei C, Wangorsch A, Kastner M, Vieths S (2002) Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 57:228–235CrossRefPubMed

Zurück zum Zitat Barber D, de la Torre F, Feo F, Florido F, Guardia P, Moreno C, Quiralte J, Lombardero M, Villalba M, Salcedo G, Rodriguez R (2008) Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy 63:1550–1558CrossRefPubMed Barber D, de la Torre F, Feo F, Florido F, Guardia P, Moreno C, Quiralte J, Lombardero M, Villalba M, Salcedo G, Rodriguez R (2008) Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy 63:1550–1558CrossRefPubMed

Zurück zum Zitat Barderas R, Villalba M, Pascual CY, Batanero E, Rodriguez R (2004) Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties. J Allergy Clin Immunol 113:1192–1198CrossRefPubMed Barderas R, Villalba M, Pascual CY, Batanero E, Rodriguez R (2004) Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties. J Allergy Clin Immunol 113:1192–1198CrossRefPubMed

Zurück zum Zitat Casquete-Roman E, Rosado-Gil T, Postigo I, Guisantes JA, Fernandez M, Torres HE, Martinez-Quesada J (2012) Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen. Ann Allergy Asthma Immunol 109:215–219CrossRefPubMed Casquete-Roman E, Rosado-Gil T, Postigo I, Guisantes JA, Fernandez M, Torres HE, Martinez-Quesada J (2012) Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen. Ann Allergy Asthma Immunol 109:215–219CrossRefPubMed

Zurück zum Zitat Focke M, Marth K, Valenta R (2009) Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 39:429–436CrossRefPubMed Focke M, Marth K, Valenta R (2009) Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 39:429–436CrossRefPubMed

Zurück zum Zitat Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM (2012) Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130:894–901 (e5)CrossRefPubMed Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM (2012) Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130:894–901 (e5)CrossRefPubMed

Zurück zum Zitat Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 6:1PubMedCentralCrossRefPubMed Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 6:1PubMedCentralCrossRefPubMed

Zurück zum Zitat Hauser M, Wallner M, Ferreira F, Mahler V, Kleine-Tebbe J (2012) Das Konzept der Pollen-Panallergene: Profiline und Polcalcine. Allergo J 21:291–293CrossRef Hauser M, Wallner M, Ferreira F, Mahler V, Kleine-Tebbe J (2012) Das Konzept der Pollen-Panallergene: Profiline und Polcalcine. Allergo J 21:291–293CrossRef

Zurück zum Zitat Kleine-Tebbe J, Balmer-Weber B, Breiteneder H, Vieths S (2010) Bet v 1 und Homologe – Verursacher der Baumpollenallergie und birkenpollenassoziierter Kreuzreaktionen. Allergo J 19:462–464 Kleine-Tebbe J, Balmer-Weber B, Breiteneder H, Vieths S (2010) Bet v 1 und Homologe – Verursacher der Baumpollenallergie und birkenpollenassoziierter Kreuzreaktionen. Allergo J 19:462–464

Zurück zum Zitat Kühn A, Radauer C, Swoboda I, Kleine-Tebbe J (2012) Molekulare Diagnostik der Fischallergie: Parvalbumine und andere Allergene. Allergo J 21:16–18CrossRef Kühn A, Radauer C, Swoboda I, Kleine-Tebbe J (2012) Molekulare Diagnostik der Fischallergie: Parvalbumine und andere Allergene. Allergo J 21:16–18CrossRef

Zurück zum Zitat Le LQ, Mahler V, Lorenz Y, Scheurer S, Biemelt S, Vieths S, Sonnewald U (2006) Reduced allergenicity of tomato fruits harvested from Lyc e 1-silenced transgenic tomato plants. J Allergy Clin Immunol 1180:1176–1183CrossRef Le LQ, Mahler V, Lorenz Y, Scheurer S, Biemelt S, Vieths S, Sonnewald U (2006) Reduced allergenicity of tomato fruits harvested from Lyc e 1-silenced transgenic tomato plants. J Allergy Clin Immunol 1180:1176–1183CrossRef

Zurück zum Zitat Ma Y, Zuidmeer L, Bohle B, Bolhaar ST, Gadermaier G, Gonzalez-Mancebo E, Fernandez-Rivas M, Knulst AC, Himly M, Asero R, Ebner C, van Ree R, Ferreira F, Breiteneder H, Hoffmann-Sommergruber K (2006) Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36:1087–1096CrossRefPubMed Ma Y, Zuidmeer L, Bohle B, Bolhaar ST, Gadermaier G, Gonzalez-Mancebo E, Fernandez-Rivas M, Knulst AC, Himly M, Asero R, Ebner C, van Ree R, Ferreira F, Breiteneder H, Hoffmann-Sommergruber K (2006) Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36:1087–1096CrossRefPubMed

Zurück zum Zitat Magler I, Nuss D, Hauser M, Ferreira F, Brandstetter H (2010) Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping. FEBS J 277:2598–2610CrossRefPubMed Magler I, Nuss D, Hauser M, Ferreira F, Brandstetter H (2010) Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping. FEBS J 277:2598–2610CrossRefPubMed

Zurück zum Zitat Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M (2000) Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 165:331–338CrossRefPubMed Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M (2000) Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 165:331–338CrossRefPubMed

Zurück zum Zitat Nouri HR, Sankian M, Vahedi F, Afsharzadeh D, Rouzbeh L, Moghadam M, Varasteh A (2012) Diagnosis of Chenopodium album allergy with a cocktail of recombinant allergens as a tool for component-resolved diagnosis. Mol Biol Rep 39:3169–3178CrossRefPubMed Nouri HR, Sankian M, Vahedi F, Afsharzadeh D, Rouzbeh L, Moghadam M, Varasteh A (2012) Diagnosis of Chenopodium album allergy with a cocktail of recombinant allergens as a tool for component-resolved diagnosis. Mol Biol Rep 39:3169–3178CrossRefPubMed

Zurück zum Zitat Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319. doi:10.1007/s40629-014-0032-2PubMedCentralCrossRefPubMed Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319. doi:10.1007/s40629-014-0032-2PubMedCentralCrossRefPubMed

Zurück zum Zitat Raulf-Heimsoth M, Rihs HP (2011) Latexallergene: Sensibilisierungsquellen und Einzelallergenprofile erkennen. Allergo J 20:241–243 Raulf-Heimsoth M, Rihs HP (2011) Latexallergene: Sensibilisierungsquellen und Einzelallergenprofile erkennen. Allergo J 20:241–243

Zurück zum Zitat van Ree R, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC (1995) Pollen-related allergy to peach and apple: an important role for profilin. J Allergy Clin Immunol 95:726–734CrossRefPubMed van Ree R, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC (1995) Pollen-related allergy to peach and apple: an important role for profilin. J Allergy Clin Immunol 95:726–734CrossRefPubMed

Zurück zum Zitat Rodriguez-Perez R, Crespo JF, Rodriguez J, Salcedo G (2003) Profilin is a relevant melon allergen susceptible to pepsin digestion in patients with oral allergy syndrome. J Allergy Clin Immunol 111:634–639CrossRefPubMed Rodriguez-Perez R, Crespo JF, Rodriguez J, Salcedo G (2003) Profilin is a relevant melon allergen susceptible to pepsin digestion in patients with oral allergy syndrome. J Allergy Clin Immunol 111:634–639CrossRefPubMed

Zurück zum Zitat Santos A, Van Ree R (2011) Profilins: mimickers of allergy or relevant allergens? Int Arch Allergy Immunol 155:191–204CrossRefPubMed Santos A, Van Ree R (2011) Profilins: mimickers of allergy or relevant allergens? Int Arch Allergy Immunol 155:191–204CrossRefPubMed

Zurück zum Zitat Schmid-Grendelmeier P (2010) Recombinant allergens. For routine use or still only science? Hautarzt 61:946–953CrossRefPubMed Schmid-Grendelmeier P (2010) Recombinant allergens. For routine use or still only science? Hautarzt 61:946–953CrossRefPubMed

Zurück zum Zitat Tanaka M, Shibata H (1995) Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin. Eur J Biochem 151:291–297CrossRef Tanaka M, Shibata H (1995) Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin. Eur J Biochem 151:291–297CrossRef

Zurück zum Zitat Tehrani M, Sankian M, Assarehzadegan MA, Falak R, Noorbakhsh R, Moghadam M, Jabbari F, Varasteh A (2011) Identification of a new allergen from Amaranthus retroflexus pollen, Ama r 2. Allergol Int 60:309–316CrossRefPubMed Tehrani M, Sankian M, Assarehzadegan MA, Falak R, Noorbakhsh R, Moghadam M, Jabbari F, Varasteh A (2011) Identification of a new allergen from Amaranthus retroflexus pollen, Ama r 2. Allergol Int 60:309–316CrossRefPubMed

Zurück zum Zitat Tinghino R, Twardosz A, Barletta B, Puggioni EM, Iacovacci P, Butteroni C, Afferni C, Mari A, Hayek B, Di Felice G, Focke M, Westritschnig K, Valenta R, Pini C (2002) Molecular, structural, and immunologic relationships between different families of recombinant calcium-binding pollen allergens. J Allergy Clin Immunol 109:314–320CrossRefPubMed Tinghino R, Twardosz A, Barletta B, Puggioni EM, Iacovacci P, Butteroni C, Afferni C, Mari A, Hayek B, Di Felice G, Focke M, Westritschnig K, Valenta R, Pini C (2002) Molecular, structural, and immunologic relationships between different families of recombinant calcium-binding pollen allergens. J Allergy Clin Immunol 109:314–320CrossRefPubMed

Zurück zum Zitat Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O (1991) Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 253:557–560CrossRefPubMed Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O (1991) Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 253:557–560CrossRefPubMed

Zurück zum Zitat Vallverdu A, Garcia-Ortega P, Martinez J, Martinez A, Esteban MI, de Molina M, Fernandez-Tavora L, Fernandez J, Bartolome B, Palacios R (1997) Mercurialis annua: characterization of main allergens and cross-reactivity with other species. Int Arch Allergy Immunol 112:356–364CrossRefPubMed Vallverdu A, Garcia-Ortega P, Martinez J, Martinez A, Esteban MI, de Molina M, Fernandez-Tavora L, Fernandez J, Bartolome B, Palacios R (1997) Mercurialis annua: characterization of main allergens and cross-reactivity with other species. Int Arch Allergy Immunol 112:356–364CrossRefPubMed

Zurück zum Zitat Verdino P, Barderas R, Villalba M, Westritschnig K, Valenta R, Rodriguez R, Keller W (2008) Three-dimensional structure of the cross-reactive pollen allergen Che a 3: visualizing cross-reactivity on the molecular surfaces of weed, grass, and tree pollen allergens. J Immunol 180:2313–2321CrossRefPubMed Verdino P, Barderas R, Villalba M, Westritschnig K, Valenta R, Rodriguez R, Keller W (2008) Three-dimensional structure of the cross-reactive pollen allergen Che a 3: visualizing cross-reactivity on the molecular surfaces of weed, grass, and tree pollen allergens. J Immunol 180:2313–2321CrossRefPubMed

Zurück zum Zitat Witke W (2004) The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol 14:461–469CrossRefPubMed Witke W (2004) The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol 14:461–469CrossRefPubMed

Zurück zum Zitat Wopfner N, Dissertori O, Ferreira F, Lackner P (2007) Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin North Am 27:29–44CrossRefPubMed Wopfner N, Dissertori O, Ferreira F, Lackner P (2007) Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin North Am 27:29–44CrossRefPubMed

Zurück zum Zitat Wopfner N, Gruber P, Wallner M, Briza P, Ebner C, Mari A, Richter K, Vogel L, Ferreira F (2008) Molecular and immunological characterization of novel weed pollen pan-allergens. Allergy 63:872–881CrossRefPubMed Wopfner N, Gruber P, Wallner M, Briza P, Ebner C, Mari A, Richter K, Vogel L, Ferreira F (2008) Molecular and immunological characterization of novel weed pollen pan-allergens. Allergy 63:872–881CrossRefPubMed