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Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage

  • Conference paper
Book cover Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/1))

Abstract

Objects: The major causes of death and disability in subarachnoid hemorrhage (SAH) may be early brain injury (EBI) and cerebral vasospasm. Although cerebral vasospasm has been studied and treated by a lot of drugs, the outcome is not improved even if vasospasm is reversed. Based on these data, EBI is considered a primary target for future research, and apoptosis may be involved in EBI after experimental SAH.

Methods: We reviewed the published literature about the relationship between SAH induced EBI and apoptosis in PubMed.

Result: Most available information can be obtained from the endovascular filament perforation animal model. After onset of SAH, intracranial pressure is increased and then cerebral blood flow is reduced. Many factors are involved in the mechanism of apoptotic cell death in EBI after SAH. In the neuronal cells, both intrinsic and extrinsic pathways of apoptosis can occur. Some antiapoptotic drugs were studied and demonstrated a protective effect against EBI after SAH. However, apoptosis in EBI after SAH has been little studied and further studies will provide us more beneficial findings. Conclusions: The study of apoptosis in EBI after experimental SAH may give us new therapies for SAH.

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Acknowledgments

This study was partially supported by grants (NS053407) from the National Institutes of Health to J.H.Z.

Conflict of interest statement We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA

    Yu Hasegawa, Hidenori Suzuki, Takumi Sozen, Orhan Altay & John H Zhang

  2. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA

    John H Zhang

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  1. Yu Hasegawa
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  2. Hidenori Suzuki
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  3. Takumi Sozen
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  4. Orhan Altay
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Correspondence to John H Zhang .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    H.-J. Steiger  & Hua Feng  & 

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Hasegawa, Y., Suzuki, H., Sozen, T., Altay, O., Zhang, J.H. (2011). Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0353-1_8

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