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Lymphatic Vessels in the Development of Tissue and Organ Rejection

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Developmental Aspects of the Lymphatic Vascular System

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 214))

Abstract

The lymphatic vascular system—amongst other tasks—is critically involved in the regulation of adaptive immune responses as it provides an important route for APC trafficking to secondary lymphatic organs. In this context, the cornea, which is the transparent and physiologically avascular “windscreen” of the eye, has served as an excellent in vivo model to study the role of the blood and lymphatic vasculature in mediating allogenic immune responses after transplantation. Especially the mouse model of high-risk corneal transplantation, where corneal avascularity is abolished by a severe inflammatory stimulus prior to keratoplasty, allows for comparison to other transplantations performed in primarily vascularized tissues and solid organs. Using this model, we recently demonstrated that especially lymphatic vessels, but not blood vessels, define the high-risk status of vascularized corneas and that anti(lymph)angiogenic treatment significantly promotes corneal allograft survival. Since evidence for lymphangiogenesis and its potential association with graft rejection is nowadays also present in solid organ transplantation, studies are currently addressing the potential benefits of anti(lymph)angiogenic treatment as a novel therapeutic concept also in solid organ grafting with promising initial results.

All authors declare no financial disclosures.

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Acknowledgements

The authors thank Birgit Regenfuss and Felix Bock (Department of Ophthalmology, University of Cologne) for helpful discussions and proofreading of the article. This work was supported by the German Research Foundation, Sonderforschungsbereich SFB 643 (B10), DFG Cu 47/4-1, and DFG Cu 47/6-1, and by the GEROK-Programme, University of Cologne (to DH).

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  1. Department of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany

    Deniz Hos & Claus Cursiefen

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  1. Deniz Hos
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Correspondence to Claus Cursiefen .

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  1. MPI for Molecular Biomedicine, Münster, Germany

    Friedemann Kiefer

  2. Hubrecht Institute, Utrecht, The Netherlands

    Stefan Schulte-Merker

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Hos, D., Cursiefen, C. (2014). Lymphatic Vessels in the Development of Tissue and Organ Rejection. In: Kiefer, F., Schulte-Merker, S. (eds) Developmental Aspects of the Lymphatic Vascular System. Advances in Anatomy, Embryology and Cell Biology, vol 214. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1646-3_10

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