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Taurine Chloramine Suppresses LPS-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglial Cells

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Book cover Taurine 10

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 975))

Abstract

The brain is sensitive to the inflammation and oxidative stress that can cause the aging or neurodegenerative diseases. We investigated the anti-neuroinflammatory activities of taurine chloramine (TauCl) on lipopolysaccharide (LPS)-treated mouse BV2 microglia mediated through heme oxygenase (HO)-1 expression. TauCl inhibited the protein expressions of prostaglandin E2 (PGE2), cyclooxygenase (COX)-2, nitric oxide (NO), and inducible nitric oxide synthase (iNOS) in LPS-treated BV2 microglia. TauCl markedly inhibited interleukin-6 (IL-6), interleukin-1𝛽 (IL-1𝛽) and tumor necrosis factor-𝛼 (TNF-𝛼) production. These effects were related to the suppression of the degradation and phosphorylation of inhibition of nuclear factor kappa B-𝛼 (I𝜅B-𝛼), translocation of nuclear factor kappa B (NF-𝜅B) as well as DNA binding activity. In addition, TauCl induced the HO-1 expression by increasing the nuclear factor E2-related factor 2 (Nrf2) translocation to the nucleus in mouse BV2 microglia. These findings suggest that TauCl has protective effects of neurodegenerative disorders caused by neuroinflammation.

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Abbreviations

(IκB)-α:

Inhibitor kappa B-α

COX-2:

Cyclooxygenase-2

HO:

Heme oxygenase

IL-1β:

Interleukin-1β

IL-6:

Interleukin-6

iNOS:

Inducible nitric oxide synthase

LPS:

Lipopolysaccharide

NF-κB:

Nuclear factor-kappa B

NO:

Nitric oxide

Nrf2:

Nuclear factor-E2-related factor 2

PGE2 :

Prostaglandin E2

TauCl:

Taurine chloramine

TNF-α:

Necrosis factor-α

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B01006822).

Author information

Authors and Affiliations

  1. College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, South Korea

    Dong-Sung Lee

  2. Division of Food Science and Nutrition, Graduate School of Biohealth Science, Gwangju University, Gwangju, 61743, South Korea

    Ki Han Kwon

  3. Department of Food Science and Nutrition, College of Health, Welfare, and Education, Gwangju University, Gwangju, 61743, South Korea

    Ki Han Kwon

  4. Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu, 550-749, South Korea

    Sun Hee Cheong

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  1. Dong-Sung Lee
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  2. Ki Han Kwon
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Corresponding author

Correspondence to Sun Hee Cheong .

Editor information

Editors and Affiliations

  1. Department of Life Sciences, University of Seoul, Seoul, South Korea

    Dong-Hee Lee  & Ha Won Kim  & 

  2. College of Medicine, University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, New York, USA

    Eunkyue Park

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Lee, DS., Kwon, K.H., Cheong, S.H. (2017). Taurine Chloramine Suppresses LPS-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglial Cells. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_12

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