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Heart failure and the aging myocardium: Possible role of cardiac mitochondria

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Abstract

The incidence of congestive heart failure (CHF) increases with advancing age and many of these individuals have diastolic dysfunction with preserved systolic function. The role of cardiac mitochondrial function to diastolic dysfunction/heart failure has not been studied extensively. This review discusses the mitochondrial changes that occur with age and their possible contribution to myocardial aging and CHF (e.g., mitochondrial structure, mitochondrial function, possible mechanisms, and physiologic implications).

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  1. Gerontology Division, RA-440, Beth, Israel Hospital, 330 Brookline Avenue, 02215, Boston, MA

    Jeanne Y. Wei

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  1. Jeff A. Odiet
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Odiet, J.A., Wei, J.Y. Heart failure and the aging myocardium: Possible role of cardiac mitochondria. Heart Failure Rev 1, 139–149 (1996). https://doi.org/10.1007/BF00126378

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