Abstract
To assess the biventricular response of the clearance rate of carbon-11 acetate as an index of myocardial oxidative metabolism to increase in work-load, dynamic positron emission tomography was performed at rest and during dobutamine infusion in 14 normal subjects. The clearance rate constant (Kmono) of the left ventricular (LV) myocardium increased during dobutamine infusion (0.112±0.020 min−1 vs 0.065±0.015 min−1 at rest) (P<0.001) in proportion to the increase in the pressure-rate product. Kmono in the right ventricular (RV) myocardium also increased (0.080±0.018 min−1 vs 0.034±0.013 min−1 at rest) (P<0.001), with an excellent correlation with the LV Kmono (r=0.920). The fact that the increase in RV Kmono during dobutamine infusion was greater (158%±81%) than that in LV Kmono (79%±39%) (P < 0.005) indicates a greater increase in oxidative metabolism in the RV in response to inotropic stimulation in normal subjects.
Similar content being viewed by others
References
Groper-McKay M, Schelbert HR, Schwaiger M, Sochor SC, Carson R, Henze E, Phelps ME. Identification of impaired metabolic reserve by atrial pacing in patients with significant coronary artery stenosis. Circulation 1986; 74:281–292.
Schelbert H, Henze E, Sochor H, Hansen H, Selin C, Huang SC, Phelps ME. Effects of substrate availability on myocardial C-11 palmitate kinetics by positron emission tomography in normal subjects and patients with ventricular dysfunction. Am Heart J 1986; 111:1055–1064.
Schön HR, Schelbert HR, Robinson G, Najafi A, Huang SC, Hansen H, Barrio J, Kuhl DE, Phelps ME. C-11-labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. I. Kinetics of C-11 palmitic acid in normal myocardium. Am Heart J 1982; 103:532–547.
Camici P, Araujo LI, Spinks T, et al. Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina. Circulation 1986; 74:81–88.
Marshall RC, Tillisch JH, Phelps ME, Huang SC, Carson R, Henze E, Schelbert HR. Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18F-labeled fluorodeoxyglucose and N-13 ammonia. Circulation 1983; 67:766–788.
Tamaki N, Yonekura Y, Yamashita K, Saji H, Magata Y, Senda M, Konishi Y, Hirata K, Ban T, Konishi J. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol 1989; 64:860–865.
Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M, Schelbert HR. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 1986; 314:884–888.
Brown M, Marshall DR, Sobel BE, Bergmann SR. Delineation of myocardial utilization with carbon-11-labeled acetate. Circulation 1987; 76:687–696.
Brown MA, Myears DW, Bergmann SR, Noninvasive assessment of canine myocardial oxidative metabolism with carbon-11 acetate and dynamic positron emission tomography. J Am Coll Cardiol 1988; 12:1054–1063.
Buxton DB, Schwaiger M, Nguyen A, Phelps ME, Schelbert MR. Radiolabeled acetate as a tracer of myocardial tricarboxylic acid cycle flux. Circ Res 1988; 63:628–634.
Buxton DB, Nienaber CA, Luxen A, Ratib O, Hansen H, Phelps ME, Schelbert HR. Noninvasive quantitation of regional myocardial oxygen consumption in vivo with 1-11C acetate and dynamic positron emission tomography. Circulation 1989; 79:134–142.
Ambrecht JJ, Buxton DB, Brunken RC, Phelps ME, Schelbert MR. Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]-acetate and dynamic positron tomography. Circulation 1989; 80:863–872.
Gropler RJ, Siegel BA, Geltman EM. Myocardial uptake of carbon-11-acetate as an indirect estimate of regional myocardial blood flow. J Nucl Med 1991; 32:245–251.
Henes CG, Bergmann SR, Walsh MN, Sobel BE, Geltman EM. Assessment of myocardial oxidative metabolic reserve with positron emission tomography and carbon-11 acetate. J Nucl Med 1989;30:1489–1499.
Walsh MN, Geltman EM, Brown MA, Henes CG, Weinheimer CJ, Sobel BE, Bergmann SR. Noninvasive estimation of regional myocardial oxygen consumption by positron emission tomography using carbon-11 acetate in patients with myocardial infarction. J Nucl Med 1989; 30:1798–1808.
Pike VW, Eakins MN, Allan RM, Selwyn AP. Preparation of [1-11C]acetate as agent for the study of myocardial metabolism by positron emission tomography. Int J Appl Radiat Isot 1982;33:505–512.
Stratmann HG, Kennedy H. Evaluation of coronary artery disease in the patients unable to exercise: alternatives to exercise stress testing. Am Heart J 1989; 117:1344–1365.
Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R, Kambara H, Kawai C, Konishi J. Metabolic reserve in normal myocardium assessed by positron emission tomography with C-11 palmitate. Ann Nucl Med 1991; 5:53–58.
Senda M, Tamaki N, Yonekura Y, Tanada S, Murata K, Hayashi N, Fujita T, Konishi J, Torizuka K, Ishimatsu K, Takami K, Tanaka E. Performance characteristics of Positologica III, a whole body positron emission tomograph. J Comput Assist Tomogr 1985; 9:940–946.
Randle PJ, England PJ, Denton RM. Control of the tricarboxylate cycle and its interaction with glycolysis during acetate utilization in rat heart. Biochem J 1970; 117:677–695.
Tuttle RR, Millis J. Dobutamine. Development of new catecholamine to selectively increase cardiac contractility. Circ Res 1975;36:185–196.
Berthe C, Pierard LA, Hiernaux M, Tratteur G, Lempereur P, Carlier J, Kulbertus HE. Predicting the extent and location of coronary artery disease in acute myocardial infarction by echocardiography during dubutamine infusion. Am J Cardiol 1986;58:1167–1172.
Mason JR, Palac RT, Freeman ML, Virupannavar S, Loeb HS, Kaplan E, Grunnar RM. Thallium-201 scintigraphy during dobutamine infusion: nonexercise-dependent screening test for coronary disease. Am Heart J 1984; 107:481–485.
Meyer SL, Curry GC, Donsky MS, Twieg DB, Parkey RW, Willerson JT. Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease. Am J Cardiol 1976; 8:103–108.
Nelson RR, Gobel FL, Jorgensen CR, Wang K, Wang Y, Taylor HL. Hemodynamic prediction of myocardial oxygen consumption during static and dynamic exercise. Circulation 1974; 50:1179–1189.
Rooke GA, Feigl EO. Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting. Circ Res 1982; 50:273–286.
Ambrecht JJ, Buxton DB, Schelbert HR. Validation of [1-11C] acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic and hyperemic canine myocardium. Circulation 1990; 81:1594–1605.
Gropler RJ, Siegel BA, Lee KJ, et al. Nonuniformity in myocardial accumulation of fluorine-18-fluorodeoxyglucose in normal fasted humans. J Nucl Med 1990; 31:1949–1956.
Cannon PJ, Dell RB, Dwyer EM Jr. Measurement of regional myocardial perfusion in man with 133Xenon and a scintillation camera. J Clin Invest 1972; 51:964–977.
Kusachi S, Nishiyama O, Yasuhara K, Saito D, Haraoka S, Nagashima H. Right and left ventricular oxygen metabolism in open-chest dogs. Am J Physiol 1982; 243: H761-H770.
Saito D, Yamada N, Kusachi S, Tani H, Shimizu A, Hina K, Watanabe H, Ueeda M, Mima T, Tsuji T, Haraoka S. Coronary reserve and oxygen metabolism of the right ventricle. Jpn Circ J 1989; 53:1310–1316.
Author information
Authors and Affiliations
Additional information
Correspondence to: N. Tamaki
Rights and permissions
About this article
Cite this article
Tamaki, N., Magata, Y., Takahashi, N. et al. Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion. Eur J Nucl Med 20, 231–237 (1993). https://doi.org/10.1007/BF00170004
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00170004