Skip to main content
SpringerLink
Log in

Topical indomethacin in the treatment of chronic cystoid macular edema

  • Clinical Investigations
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Eighty percent of 30 eyes with chronic cystoid macular edema (CME) after cataract extraction achieved improved visual acuity of three or more lines when treated with 1% indomethacin eye drops. Of these patients 53% demonstrated an “on/off” phenomenon induced by the initiation and cessation of treatment documented by visual acuity measurements and fluorescein angiography. This “on/off” phenomenon suggests that there is a direct relationship between the use of 1% indomethacin eye drops and the resolution of chronic CME after cataract extraction. Previous studies on the treatment of CME with indomethacin have not addressed the use of indomethacin eye drops for chronic CME.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bhattacherjee P, Eakins KE (1974) Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin. Br J Pharmacol 50:227–230

    Google Scholar 

  2. Bradford DJ, Wilkinson CP, Bradford RH (1988) Cystoid macular edema followin extracapsular cateract extraction and posterior chamber intraocular lens implantation. Retina 8:161–164

    Google Scholar 

  3. Burnett J, Tessler H, Isenberg S, Tso M (1983) Double-masked trial of fenoprofen sodium: treatment of chronic aphakic cystoid macular edema. Ophthalmic Surg 14:150–152

    Google Scholar 

  4. Cox SN, Hay E, Bird AC (1988) Treatment of chronic macular edema with acetazolamide. Arch Ophthalmol 106:1190–1195

    Google Scholar 

  5. Cunha-Vaz JG, Travessos A (1984) Breakdown of the blood-retinal barriers and cystoid macular edema. Survey Ophthalmol 28 [Suppl] 485–492

    Google Scholar 

  6. Flach AT, Dolan BJ, Irvine AR (1987) Effectiveness of ketrolac tromethamine 0.5% ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema. Am J Ophthalmol 102:479–486

    Google Scholar 

  7. Flower R, Gryglewski R, Hevberczynska-Cedro K, Vane JR (1972) The effect of anti-inflammatory drugs on a cell-free prostaglandin synthesis system from the dog spleen. Nature New Biol 238:104–106

    Google Scholar 

  8. Francois J, Verbracken H (1980) Complications in 1,000 consecutive intracapsular cateract extractions. Ophthalmologica 180:121–128

    Google Scholar 

  9. Gass JDM, Norton EWD (1966) Cystoid macular edema and papilledema following cataract extraction. Arch Ophthalmol 76:646–661

    Google Scholar 

  10. Gass JDM, Norton EWD (1969) Follow-up study of cystoid macular edema following cataract extraction. Trans Am Acad Ophthalmol Otolaryngol 73:665–682

    Google Scholar 

  11. Gehring JR (1968) Macular edema following cataract extraction. Arch Ophthalmol 80:626–631

    Google Scholar 

  12. Harris WJ, Taylor BC, Winslow L (1977) Cystoid macular edema following intraocular lens implantation. Ophthalmic Surg 8:134–137

    Google Scholar 

  13. Hitchings RA, Chisholm IH, Bird AC (1975) Aphakic macular edema: incidence and pathogenesis. Invest Ophthalmol 14:68–72

    Google Scholar 

  14. Irvine AR (1976) Cystoid maculopathy. Surv Ophthalmol 21:1–17

    Google Scholar 

  15. Irvine AR, Bersky R, Crowder BM, Forster R, Hunter D, Kulvin SM (1971) Macular edema after cataract extraction. Ann Ophthalmol 3:1234–1240

    Google Scholar 

  16. Irvine SR (1953) A newly defined vitreous syndrome following cataract surgery, interpreted according to recent concepts of structure of vitreous. 7th F.I. Proctor Lecture. Am J Ophthalmol 36:599–619

    Google Scholar 

  17. Jacobson DR, Dellaporta A (1974) Natural history of cystoid macular edema after cataract extraction. Am J Ophthalmol 77:445–447

    Google Scholar 

  18. Jaffe NS, Clayman HM, Jaffe MS (1981) Cystoid macular edema after intracapsular and extracapsular cataract extraction with and without an intraocular lens. Ophthalmology 88:942–946

    Google Scholar 

  19. Jampol LM (1985) Aphakic cystoid macular edema. A hypothesis. Arch Ophthalmol 103:1134–1135

    Google Scholar 

  20. Jampol LM, Neufeld AH, Sears ML (1975) Pathways for the response of the eye to injury. Invest Ophthalmol 14:184–189

    Google Scholar 

  21. Klein RM, Katzin HM, Yannuzzi LA (1979) The effect of indomethacin pretreatment on aphakic cystoid macular edema. Am J Ophthalmol 87:487–489

    Google Scholar 

  22. Kraff MC, Sanders DR, Jampol LM, Peyman GA, Lieberman HL (1982) Prophylaxis of pseudophakic cystoid macular edema with tropical indomethacin. Ophthalmology 89:885–890

    Google Scholar 

  23. Kratz RP, Mazzocco IR, Davidson B, Colvard DM (1981) The Shearing intraocular lens: a report of 1,000 cases. Am Intraocular Implant See J 7:55–57

    Google Scholar 

  24. Kulkarni PS, Srinivesan BD (1983) Steroidal and nonsteroidal anti-inflammatory drugs in ocular inflammation. Ocular Inflam Ther 1:11–18

    Google Scholar 

  25. McEntyre JM (1978) A successful treatment of aphakic cystoid macular edema. Ann Ophthalmol 10:1219–1224

    Google Scholar 

  26. Meredith TA, Kenyon KR, Singerman LJ, Fine SL (1976) Perifoveal vascular leakage and macular oedema after intracapsular cataract extraction. Br J Ophthalmol 60:765–769

    Google Scholar 

  27. The Miami Study Group (1979) Cystoid macular edema in aphakic and pseudophakic eyes. Am J Ophthalmol 88:45–48

    Google Scholar 

  28. Miyake K, Sugiyama S, Norimatsu I, Ozawa T (1978) Prevention of cystoid macular edema after lens extraction by tropical indomethacin. Radio-immunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedures. Graefe's Arch Clin Exp Ophthalmol 209:83–88

    Google Scholar 

  29. Miyake K, Sakamura S, Miura H (1980) Long-term follow-up study on prevention of aphakic cystoid macular edema by topical indomethacin. Br J Ophthalmol 64:324–328

    Google Scholar 

  30. Miyake K, Sugiyama S, Norimatsu I, Ozawa T (1980) Aqueous prostaglandins in persistent cystoid macular edema secondary to vitreous incarceration: Effects of pars plana vitrectomy. Jpn J Ophthalmol 24:335–345

    Google Scholar 

  31. Podos SM, Becker B (1976) Comparison of ocular prostaglandin synthesis inhibitors. Invest Ophthalmol 15:841–844

    Google Scholar 

  32. Sanders DR, Goldstick B, Kraff C, Hutchins R, Bernstein MS, Evans MA (1983) Aqueous penetration of oral and topical indomethacin in humans. Arch Ophthalmol 101:1614–1616

    Google Scholar 

  33. Schepens CL, Avila MP, Jalkh AE (1984) Role of the vitreous in cystoid macular edema. Survey Ophthalmol 28 (Suppl) 505–511

    Google Scholar 

  34. Shepard DD (1977) Intraocular lens implantation-analysis of 500 consecutive cases. Ophthalmic Surg 8:57–63

    Google Scholar 

  35. Stark WJ, Maumenee AE, Fagadau W, Datiles M, Baker CC, Worthen D, Klein P, Auer C (1984) Cystoid macular edema in pseudophakia. Survey Ophthalmol 28 [Suppl] 442–451

    Google Scholar 

  36. Stern AL, Taylor DM, Dalburg LA, Cosentino RT (1981) Pseudophakic cystoid maculopathy. A study of 50 cases. Ophthalmology 88:942–946

    Google Scholar 

  37. Taylor DM, Sachs SW, Stern AL (1984) Aphakic cystoid macular edema. Long-term clinical observations. Surv Ophthalmol 28 [Suppl] 437–444

    Google Scholar 

  38. Tso MOM, Shih CY (1977) Experimental macular edema after lens extraction. Invest Ophthalmol 16:381–392

    Google Scholar 

  39. Yannuzzi LA, Landau AN, Turtz AJ (1981) Incidence of aphakic cystoid macular edema with the use of topical indomethacin. Ophthalmology 88:947–954

    Google Scholar 

  40. Yoshioka H, Kawashima K (1971) Macular edema following cataract extraction. Acta Soc Ophthalmol Jpn 75:2269–2273

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Retina Division, Doris Stein Eye Research Center, Jules Stein Eye Institute, Department of Ophthalmology UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA

    Michael Peterson, Marc O. Yoshizumi, Robert Hepler, Bartly Mondino & Allan Kreiger

Authors
  1. Michael Peterson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marc O. Yoshizumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Robert Hepler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bartly Mondino
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Allan Kreiger
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Correspondence to: M.O. Yoshizumi

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peterson, M., Yoshizumi, M.O., Hepler, R. et al. Topical indomethacin in the treatment of chronic cystoid macular edema. Graefe's Arch Clin Exp Ophthalmol 230, 401–405 (1992). https://doi.org/10.1007/BF00175922

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00175922

Keywords

Search

Navigation