Summary
Artificial skin, applied as a completely synthetic bilaminate skin evolving into a completely biologic self-skin replacement, was initially used in 1980. It has been used in 121 patients to date, at the Massachusetts General Hospital and the Boston Unit of the Shriners Burns Institute with follow-up as long as ten years. This report describes the generally gratifying long-term results with the use of artificial skin in massive burns.
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References
Atnip RG, Burke JF (1985) Skin coverage for burns. Contemp Orthop 10:13–22
Atnip RG, Burke JF (1985) Skin coverage for burns. Contemp Surg 27:37–45
Bell E, Ehrlich HP, Brittle DJ, Nahatsuji T (1981) Living tissue formed in vitro and accepted as skin-equivalent tissue of full-thickness. Science 211:1052–1054
Burke JF, Yannas IV, Quinby WC, Bondoc CC, Jung WK (1984) Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 194:413–428
Burke JF (1987) Observations on the development and clinical use of artificial skin: an attempt to employ regeneration rather than scar formation in wound healing. Jpn J Surg 17:431–438
Burke JF (1983) Observations on the development of an artificial skin: presidential address, 1982 American Burn Associations Meeting. J Trauma 23:543–551
Burke JF (1984) The effects of the configuration of an artificial extracellular matrix on the development of a functional dermis. In: Trelstad R (ed) The role of extracellular matrix in development. Liss, New York, pp 351–355
Burt AM, Pallett CD, Sloane JP, O'Hare MJ, Schafler KF, Yardeni P, Elvad A, Clarke JA, Gusterson BA (1989) Survival of cultured allografts in patients with burns assessed with probes specific for Y chromosome. BMJ 298:915–917
Gallico GC, O'Connor NE, Compton CC, Kehinde EO, Green H (1984) Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 311:448–451
Hansbrough JF (1990) Current status of skin replacements for coverage of extensive burn wounds. J Trauma 30: S155-S150
Hansbrough JF, Boyce ST, Cooper ML, Foreman TJ (1989) Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate. JAMA 262:2125–2130
Heck EL, Bergstresser PR, Baxter CR (1985) Composite skin graft: frozen dermal allografts support the engraftment and expansion of autologous epidermis. J Trauma 25:106–112
Heimbach D, Luterman A, Burke JF, Cram A, Herndon D, Hunt J, Jordan M, McManus W, Solem L, Warden G, Zawacki B (1988) Artificial dermis for major burns: a multi-center randomized clinical trial. Ann Surg 203:313–320
Jaksic T, Burke JG (1987) The use of “artificial skin” for burns. Ann Rev Med 38:107–117
Tompkins RG, Burke JF (1990) Progress in burn treatment and the use of artificial skin. World J Surg 14:819–824
Tompkins RG, Burke JF (1992) Burn wound closure using permanent skin replacement materials. World J Surg 16:47–52
Tompkins RG, Burke JF (1986) Burn therapy 1985: acute management. Intensive Care Med 12:289–295
Tompkins RG, Hilton JF, Burke JF, Schoenfeld DA, Hegarty MT, Bondoc CC, Quinby WC, Behringer GE, Ackroyd FW (1989) Increased survival after massive thermal injuries in adults: preliminary report using artificial skin. Crit Care Med 17:734–740
Tompkins RG, Burke JF, Schoenfeld DA, Bondoc CC, Quinby WC, Behringer GC, Ackroyd FW (1986) Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974–1984). Ann Surg 204:272–281
Yannas IV, Burke JF, Orgill DP, Skrabut EM (1982) Wound tissue can utilize a polymeric template to synthesize a functional extension of skin. Science 215:174–176
Yannas IV, Burke JF, Gordon PL, Huang C, Rubenstein RH (1980) Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res 14:107–131
Yannas IV, Burke JF (1980) Design of an artificial skin. I. Basic design principles. J Biomed Mater Res 14:65–81
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Sheridan, R.L., Hegarty, M., Tompkins, R.G. et al. Artificial skin in massive burns — results to ten years. Eur J Plast Surg 17, 91–93 (1994). https://doi.org/10.1007/BF00176923
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DOI: https://doi.org/10.1007/BF00176923