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Localization of parathyroid enlargement: experience with technetium-99m methoxyisobutylisonitrile and thallium-201 scintigraphy, ultrasonography and computed tomography

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Abstract

Technetium-99m methoxyisobutylisonitrile (MIBI), like thallium-201, has recently been introduced as a myocardial perfusion agent and is now also showing very promising results in parathyroid scintigrapy. The results of 201Tl/99mTc-pertechnetate and 99mTc-MIBI/99mTc-pertechnetate subtraction scintigraphy, ultrasonography and computed tomography are presented in a series of 43 patients operated on for hyperparathyroidism. All four imaging modalities were confirmed to be reliable, scintigraphy being the most accurate. Sensitivities ranged from 81% to 95%, that of 99mTc-MIBI being the highest. Moreover this tracer, which has more favourable physical and also biochemical properties, yielded images of superior quality. This allowed localization of the lesion by visual inspection only in as many as 86% of the patients with positive 99mTc-MIBI/99mTc-pertechnetate subtraction scintigraphy. We believe that the higher sensitivity, superior image quality and lower cost of 99mTc-MIBI imaging will make 99mTc-MIBI the new radiopharmaceutical of choice for parathyroid scintigraphy (when one takes into account the stability of labelling with large activities it is possible to perform three or four cardiac studies together with one parathyroid scintigraphic examination using one lyophililzed vial).

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Authors and Affiliations

  1. Ospedale Civile, Istituto di Medicina Nucleare, Udine, Italy

    Onelio Geatti, Pier Giuseppe Orsolon & Ugo Paolo Guerra

  2. Division of Nuclear Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Brahm Shapiro

  3. Ospedale Civile, Endocrinologia, Udine, Italy

    Gianni Proto

  4. Ospedale Civile, Nefrologia, Udine, Italy

    Francesco Antonucci

  5. Ospedale Civile, Istituto di Radiologia II, Udine, Italy

    Daniele Gasparini

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  1. Onelio Geatti
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Geatti, O., Shapiro, B., Orsolon, P.G. et al. Localization of parathyroid enlargement: experience with technetium-99m methoxyisobutylisonitrile and thallium-201 scintigraphy, ultrasonography and computed tomography. Eur J Nucl Med 21, 17–22 (1994). https://doi.org/10.1007/BF00182301

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  • DOI: https://doi.org/10.1007/BF00182301

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