Abstract
Purpose
The effectiveness of renal transcatheter arterial embolization (TAE) with a mixture of ethanol and iodized oil (Lipiodol) was analyzed retrospectively in 27 patients with unresectable renal cell carcinoma.
Methods
Symptomatic or permanent palliation by TAE was performed with the intent to achieve total or partial ablation of the kidney with 10–28 ml of embolic material in a 3 ∶ 1 mixture of ethanol and iodized oil. Clinical, angiographic, and computed tomographic (CT) follow-up were analyzed. Cumulative survival was estimated with the Kaplan-Meier method.
Results
Partial (5) or complete (22) ablation of the embolized kidneys was achieved in all cases. Follow-up CT after 1 month revealed Lipiodol uptake in the tumor area (14/14), decreased size of the tumor (6/14), and gas formation (7/14). Pulmonary metastasis improved significantly in one patient after transcatheter arterial embolization and adjunctive chemotherapy. Overall median survival of the 27 patients was 8.5 months. The median survival was 23 months in 10 patients with stage III, three of whom are still alive, and was 7 months in 15 patients with stage IV tumors.
Conclusion
The mixture of ethanol and Lipiodol is not only a convenient embolic material to use, but is also effective for selective or nonselective devascularization for unresectable renal cell carcinoma.
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References
Yune HY, Klatte EC, Richmond BD, Rabe FE (1982) Absolute ethanol in thrombotherapy of bleeding esophageal varices. AIR 138:1137–1141
Yakes WF, Haas DK, Parker SH, Gibson MD, Hopper KD, Mulligan JS, Pevsner PH, Johns JC Jr, Carter TE (1989) Symptomatic vascular malformations: Ethanol embolotherapy. Radiology 170:1059–1066
Ellman BA, Parkhill BJ, Curry TS (1981) Ablation of renal tumor with absolute ethanol: A new technique. Radiology 141:619–626
Park JH, Jeon SC, Kang HS, Im JG, Han MC, Kim CW (1986) Transcatheter renal arterial embolization with the mixture of ethanol and iodized oil (Lipiodol). Invest Radiol 21:577–580
Wallace S, Chuang VP, Swanson D, Bracken B, Hersh EM, Ayala A, Johnson D (1981) Embolization of renal carcinoma. Radiology 138:563–570
Kozak BE, Keller FS, Rosch J, Barry J (1987) Selective therapeutic embolization of renal cell carcinoma in solitary kidneys. J Urol 137:1223–1225
Gottesman JE, Crawford ED, Grossman HB, Scardino P, McCracken JD (1985) Infarction-nephrectomy for metastatic renal carcinoma. Urology 25:248–250
Ekelund L, Mansson KW, Olsson AM (1981) Palliative embolization of renal tumors: Follow-up of 19 cases. Urol Radiol 3:13–18
Kauffmann GW, Richter GM, Rohrbach R, Wenz W (1989) Prolonged survival following palliative renal tumor embolization by apillary occlusion. Cardiovasc Intervent Radiol 12:22–28
Stoesslein F, Schwenke A, Muenster W (1988) Percutaneous transluminal embolization for improved prognosis of renal cell carcinoma—dependence on tumor stages. Cardiovasc Intervent Radiol 11:91–96
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Park, J.H., Kim, S.H., Han, J.K. et al. Transcatheter arterial embolization of unresectable renal cell carcinoma with a mixture of ethanol and iodized oil. Cardiovasc Intervent Radiol 17, 323–327 (1994). https://doi.org/10.1007/BF00203951
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DOI: https://doi.org/10.1007/BF00203951