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Development of the ovarian surface and associated germ cells in the human fetus

A correlated study by scanning and transmission electron microscopy

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Summary

The ovarian surface and associated germ cells have been studied in human fetuses from 12 weeks of age until near term, using light, TEM and SEM techniques. The surface epithelium and related cords proliferate extensively, especially at midterm. The cords in the ovarian cortex appear to be linked with ingrowths from the surface epithelium, and both structures have a common basal lamina. Germ cells are always interspersed among the somatic cells of the surface epithelium and associated cords. These results indicate that both the proliferating cords and surface epithelium may contribute to the formation of early follicles. Furthermore, the occurrence, of elements having some of the features of primitive steroidogenic cells in the regions of cordsurface epithelium continuity, suggests that both structures (surface epithelium and cords) contribute somatic cells, which in addition to becoming granulosa cells, might also contribute to the provision of primitive interstitial cells.

Gonocytes tend to migrate through the developing ovarian tissue towards the surface where they become extruded into the peritoneal cavity. This phenomenon might contribute to the reduction in the number of germ cells at birth and parallels the atretic processes within the ovary.

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Authors and Affiliations

  1. Department of Anatomy, Faculty of Medicine, University of Rome, Italy

    Pietro M. Motta & Sayoko Makabe

  2. Department of Obstetrics and Gynecology, Toho University, Tokyo, Japan

    Pietro M. Motta & Sayoko Makabe

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  1. Pietro M. Motta
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  2. Sayoko Makabe
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Motta, P.M., Makabe, S. Development of the ovarian surface and associated germ cells in the human fetus. Cell Tissue Res. 226, 493–510 (1982). https://doi.org/10.1007/BF00214779

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