Abstract
The diurnal variations of serum-erythropoietin concentration ([s-EPO]) were investigated in six physically trained (T) and eight untrained (UT) men. The T subjects had a higher mean maximal oxygen uptake than UT subjects [75.7 (SEM 1.6) ml · min−1 · kg−1 versus 48.3 (SEM 1.4) ml · min−1 · kg−1, P < 0.0001] and a lower mean body mass index [BMI, 21.7 (SEM 0.7) kg · m−2 versus 24.4 (SEM 0.6) kg · m−2, P=0.02]. Each subject was followed individually for 24 h as they performed their normal daily activities. Venous blood samples were collected from awakening (0 min) until the end of the 24-h period (1440 min). Both T and UT had a nadir of [s-EPO] 120 min after awakening [10.0 (SEM 0.3) U · 1−1 versus 11.5 (SEM 2.1) U · 1−1, P > 0.05]. The UT and T increased their [s-EPO] to peak values at 960 min and 960–1200 min, respectively (ANOVA P=0.03) after awakening [UT: 18.4 (SEM 2.8) U · l−1; T: 16.2 (SEM 2.5) U · l−1, P > 0.05]. The mean 24-h [s-EPO] were 14.5 (SEM 1.0) U · l−1 and 14.9 (SEM 0.9) U · l−1 in T and UT, respectively (P > 0.05). The individual mean 24-h [s-EPO] were not correlated to body mass, BMI or maximal oxygen uptaken. Significant diurnal variations in [s-EPO] occurred in these healthy subjects irrespective of their levels of physical activity.
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Klausen, T., Dela, F., Hippe, E. et al. Diurnal variations of serum erythropoietin in trained and untrained subjects. Europ. J. Appl. Physiol. 67, 545–548 (1993). https://doi.org/10.1007/BF00241652
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DOI: https://doi.org/10.1007/BF00241652