Abstract
The unusual occurrence of neonatal hypothyroidism in monozygotic twins is reported. Scintigraphy demonstrated that permanent hypothyroidism in one resulted from an ectopic suprahyoid thyroid, while in the other, the transient hypothyroid state was associated with thyroid hemiagenesis. These findings suggest that the anomalies represent variants of the same developmental aberration.
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References
Abbassi V, Auth R (1983) Hemiagenesis of the thyroid: Clinical and radiological presentation in the pediatric patient. J Nucl Med 24:972–973
Anonymous (1979) Screening for congenital hypothyroidism (Editorial). Lancet ii:678–679
Fisher DA (1980a) Medical management of suspected cases of congenital hypothyroidism. In: Burrow GN, Dussault JH (eds.) Neonatal thyroid screening. Raven Press, New York, pp 237–240
Fisher DA (1980b) Status of neonatal hypothyroid screening: Report from the Quebec International Conference of Neonatal Screening. In: Stockigt JR, Nagataki S (eds.) Thyroid research VIII. Canberra, Australian Academy of Science, pp 1–6
Fisher DA, Hobert CJ, Garza R, Pierce CA (1970) Thyroid function in preterm fetus. Pediatrics 46:208–216
Greening WP, Sarker SK, Osborne NP (1980) Hemiagenesis of the thyroid gland. Br J Surg 67:446–448
Greig WR, Henderson AS, Boyle JA, McGirr EM, Hutchinson JH (1966) Thyroid dysgenesis in two pairs of monozygotic twins and in a mother and child. J Clin Endocrinol Metab 26:1309–1316
Hamburger JI, Hamburger SW (1970) Thyroid hemiagenesis. Arch Surg 100:319–320
Hopwood MJ, Carroll RG, Kenny FM, Foley TP (1976) Functioning thyroid masses in childhood and adolescence: Clinical surgical and pathologic correlations. J Pediatr 89:701–708
Hubble D (1953) Familial cretinism. Lancet i:1112–1117
Kaplan M, Kauli R, Raviv U, Lubin E, Laron Z (1977) Hypothyroidism due to ectopy in siblings. Am J Dis Child 131:1264–1265
Melnick JC, Stemkowski PE (1981) Thyroid hemiagenesis (hockey stick sign): A review of world literature and a report of 4 cases. J Clin Endocrinol Metab 52:247–251
Montgomery MC (1935) Lingual thyroid: A comprehensive review. West J Surg 43:661–669
Neinas FW, Gorman CA, Devine KD, Woolner LB (1973) Lingual thyroid. Clinical characteristics of 15 cases. Ann Intern Med 79:205–210
Orti E, Castells S, Qazi Q, Inamdar S (1971) Familial thyroid disease: Lingual thyroid in two siblings and hypoplasia of a thyroid lobe in a third. J Pediatr 78:675–677
Pickering DE, Fisher DA (1958) Therapeutic concepts related to hypothyroidisim in children. J Chronic Dis 7:242–263
Rosenberg T, Gilboa Y (1980) Familial thyroid ectopy and hemiagenesis. Arch Dis Child 55:639–641
Walfish PG, Ginsberg J, Rosenberg RA, Howard NJ (1979) Results of a regionalised cord blood screening program for detecting neonatal hypothyroidism. Arch Dis Child 54:171–177
Warkanay J, Selkirk JL (1955) Discordant monozygotic twins. Hypothyroidism. Am J Dis Child 89:144–148
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McLean, R., Howard, N. & Murray, I.P.C. Thyroid dysgenesis in monozygotic twins: Variants identified by scintigraphy. Eur J Nucl Med 10, 346–348 (1985). https://doi.org/10.1007/BF00251309
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DOI: https://doi.org/10.1007/BF00251309