Abstract
In many nuclear medicine applications a well defined particle size and stability of administered colloids is of great importance. A fast and reliable sizing technique for routine quality control is therefore essential. This paper evaluates autocorrelation spectroscopy with an instrument capable of analysing several peaks simultaneously. A total of nine 99mTc-labelled colloids and one 99Y-labelled colloid were studied. The autocorrelation spectroscopy measurements were compared with the standard sizing technique of microfiltration. A good agreement between the sizing techniques was found for most of the colloids. The reproducibility of successive measurements was within ±12% and ±40% when using unimodal analysis and SDP analysis, respectively. Autocorrelation spectroscopy was found to be well suited for particle sizing and stability tests of radiolabelled colloids.
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Bergqvist, L., Strand, SE. Autocorrelation spectroscopy for particle sizing and stability tests of radiolabelled colloids. Eur J Nucl Med 15, 641–645 (1989). https://doi.org/10.1007/BF00251676
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DOI: https://doi.org/10.1007/BF00251676