Summary
Scanning electron microscope studies of the aorta and other major arteries have been performed in alloxan-induced diabetic rabbits. After 5 weeks, a variety of structural abnormalities of the endothelial lining were detected including a significant increase in the number of argyrophilic cells and an increased number of craters or openings in the endothelial junctional region. Evidence of more extensive micro-damage was present after 5 months duration of diabetes. These zones with structural changes in the endothelial lining of major vessels seem to be areas of high predilection to atherosclerosis in diabetes.
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Dolgov, V.V., Zaikina, O.E., Bondarenko, M.F. et al. Aortic endothelium of alloxan diabetic rabbits: A quantitative study using scanning electron microscopy. Diabetologia 22, 338–343 (1982). https://doi.org/10.1007/BF00253578
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DOI: https://doi.org/10.1007/BF00253578