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Paired helical filaments and straight tubules in astrocytes: an electron microscopic study in dementia of the Alzheimer type

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Abstract

Ultrastructural investigation of the hippocampal CA1 and CA4 of nine sutopsy-proven cases of dementia of the Alzheimer type (duration of disease: 3–16 years; age: 76–92 years) revealed paired helical filaments (PHFs) and straight tubules (STs) in astrocytes of three advanced cases of long duration (>13years). The PHFs and STs were indistinguishable from those seen in neurons. The abnormal glial fibrils were confined to the astrocytic processes that were associated with small vessels or, more frequently, with ghost tangles. In both locations the astrocytic PHFs and STs were located in the cytoplasm without limiting membranes, and were thicker than the straight filaments that composed ghost tangles. These findings, combined with the presence of regular constrictions of astrocytic PHFs, suggest that abnormal astrocytic fibers are produced by the glial cells, not engulfed by them. In addition, the presence of these abnormal glial filaments in only advanced, long-duration cases of dementia of the Alzheimer type suggests that disease duration has a significant effect upon the formation of these astrocytic profiles.

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References

  1. Brion JP, Passareiro H, Nunez J, Flament-Durand J (1985) Mise en evidence de la proteine Tau au niveau des lesions de degenerescence neurofibrillaire de la maladie d'Alzheimer. Arch Biol 95: 229–235

    Google Scholar 

  2. Delacourte A, Defossez A (1986) Alzheimer's disease: tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments. J Neurol Sci 76: 173–786

    Google Scholar 

  3. Ghadially FN (1988) Ultrastructural pathology of the cell and matrix, 3rd edn. Butterworths, London

    Google Scholar 

  4. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM (1986) Microtubule-associated protein tau: a component of Alzheimer paired helical filaments. J Biol Chem 261: 6084–6089

    Google Scholar 

  5. Hirano A (1981) A guide to neuropathology. Igaku-Shoin, New York, pp 144–150

    Google Scholar 

  6. Ikeda K, Haga C, Akiyama H, Kase K, Iritani S (1992) Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles. Neurosci Lett 148: 126–128

    Google Scholar 

  7. Ikeda K, Akiyama H, Haga C, Haga S (1992) Evidence that neurofibrillary tangles undergo glial modification. Acta Neuropathol 85: 101–104

    Google Scholar 

  8. Ikeda K, Haga C, Oyanagi S, Iritani S, Kosaka K (1992) Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles. J Neurol 239: 191–194

    Google Scholar 

  9. Ikeda K, Akiyama H, Kondo H, Ikeda K (1993) Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type. Neurosci Lett 162: 176–178

    Google Scholar 

  10. Kosik KS, Joachim CL, Selkoe DJ (1986) Microtubule-associated protein tau is a major component of paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 83: 4044–4048

    Google Scholar 

  11. Nakano I, Iwatsubo T, Otsuka N, Kamei M, Matsumura K, Mannen T (1992) Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease. Acta Neuropathol 83: 228–232

    Google Scholar 

  12. Nishimura M, Namba Y, Ikeda K, Oda M (1992) Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy. Neurosci Lett 143: 35–38

    Google Scholar 

  13. Nukina N, Ihara Y (1986) One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem 99: 1541–1544

    Google Scholar 

  14. Nukina N, Quan Y, Nakano I, Otomo E (1992) Widespread tau abnormality in a case of corticobasal degeneration. Clin Neurol 32: 1093–1101

    Google Scholar 

  15. Okamoto K, Hirano A, Yamaguchi H, Hirai S (1983) The fine structure of eosinophilic stage of Alzheimer's neurofibrillary tangles. J Clin Electron Microsc 16: 77–82

    Google Scholar 

  16. Papasozomenos SC (1989) Tau protein immunoreactivity in dementia of the Alzheimer type. I. Morphology, evolution, distribution, and pathogenetic implications. Lab Invest 60: 123–137

    Google Scholar 

  17. Papasozomenos SC (1989) Tau protein immunoreactivity in dementia of the Alzheimer type. II. Electron microscopy and pathogenetic implications. Effects of fixation of the morphology of the Alzheimer's abnormal filaments. Lab Invest 60: 375–389

    Google Scholar 

  18. Pollock N, Mirra SS, Binder LI, Hansen LA, Wood JG (1986) Filamentous aggregates in Pick's disease, progressive supranuclear palsy, and Alzheimer's disease share antigenic determinants with microtubule-associated protein, tau. Lancet II: 1211

    Google Scholar 

  19. Probst A, Ulrich J, Heitz PU (1982) Senile dementia of Alzheimer type: astroglial reaction to extracellular neurofibrillary tangles in hippocampus. Acta Neuropathol (Berl) 57: 75–79

    Google Scholar 

  20. Yamada T, McGeer PL, McGeer EG (1992) Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue. Neurosci Lett 135: 99–102

    Google Scholar 

  21. Yamada T, Calne DB, Akiyama H, McGeer EG, McGeer PL (1993) Further observations on Tau-positive glia in the brains with progressive supranuclear palsy. Acta Neuropathol 85: 308–315

    Google Scholar 

  22. Yamaguchi H, Nakazato Y, Kawarabayashi T, Ishiguro K, Ihara Y, Morimatsu M, Hirai S (1991) Extracellular neurofibrillary tangles associated with degenerating neurites and neurophil threads in Alzheimer-type dementia. Acta Neuropathol 81: 603–609

    Google Scholar 

  23. Yamazaki M, Nakano I, Imazu O, Kaieda R, Terashi A (1994) Astrocytic straight tubules in the brain of a patient with Pick's disease. Acta Neuropathol 88: 587–591

    Google Scholar 

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Yamazaki, M., Nakano, I., Imazu, O. et al. Paired helical filaments and straight tubules in astrocytes: an electron microscopic study in dementia of the Alzheimer type. Acta Neuropathol 90, 31–36 (1995). https://doi.org/10.1007/BF00294456

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  • DOI: https://doi.org/10.1007/BF00294456

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