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Polyglucosan bodies in sural nerve biopsies

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Summary

The presence of polyglucosan bodies in sural nerves collected over a 16-year period was studied in relation to age, sex, presence of polyneuropathy, and concomitant presence of central nervous system disorder. Polyglucosan bodies have been seen in only one patient without a polyneuropathy. This patient was suffering from Lafora's disease. In all other sural nerves positive for polyglucosan bodies a polyneuropathy was present. Within this group the prevalence of polyglucosan bodies was positively correlated with age, and if a central nervous system disorder was associated, this prevalence was more distinct. With semiquantitative measurements of the surface of polyglucosan bodies a significant correlation was found between age and percentage of large bodies.

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Authors and Affiliations

  1. Institute of Neurology, University Hospital Nijmegen, P. O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    H. L. S. M. Busard, A. A. W. M. Gabreëls-Festen, W. O. Renier & F. J. M. Gabreëls

  2. Department of Statistical Consultation, University Hospital Nijmegen, P. O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    M. A. van 't Hof

Authors
  1. H. L. S. M. Busard
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  2. A. A. W. M. Gabreëls-Festen
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  3. M. A. van 't Hof
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  4. W. O. Renier
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  5. F. J. M. Gabreëls
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Busard, H.L.S.M., Gabreëls-Festen, A.A.W.M., van 't Hof, M.A. et al. Polyglucosan bodies in sural nerve biopsies. Acta Neuropathol 80, 554–557 (1990). https://doi.org/10.1007/BF00294618

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  • DOI: https://doi.org/10.1007/BF00294618

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