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Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro

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Summary

Myelin phagocytosis in Wallerian degeneration of peripheral nerves depends on invasion of nerves by non-resident macrophages. The present study was done to clarify the role of the macrophage complement receptor type 3 (CR3) in myelin removal. Myelin phagocytic capacity of invading macrophages was abolished by treatment of cultured nerves and macrophages with anti-CR3 antibody or by serum complement depletion with cobra venom factor. This indicates that myelin phagocytosis is mediated by the macrophage CR3.

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Supported by grant 609/2-1 from the Deutsche Forschungsgemeinschaft

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Brück, W., Friede, R.L. Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro. Acta Neuropathol 80, 415–418 (1990). https://doi.org/10.1007/BF00307696

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  • DOI: https://doi.org/10.1007/BF00307696

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