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Direct effects of angiotensin II on glomerular ultrastructure in the rainbow trout, Salmo gairdneri

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Summary

Slices from the kidneys of the rainbow trout which were exposed to 10-6 or 10-5 M angiotensin II (AII) and isolated glomeruli exposed to 10-7 or 10-5 M AII showed ultrastructural changes compared to control tissues incubated without AII. The studies indicate that angiotensin II has a direct action on glomerular ultrastructure, flattening the epithelial podocytes and broadening the primary processes with fusion of pedicels in extreme cases. These changes suggest a probable effect of AII on water permeability of the trout glomerulus, an intrarenal action which is believed to form an essential part of the antidiuretic adaptation to increased environmental salinities.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Exeter, Exeter, United Kingdom

    J. A. Brown

  2. Department of Zoology, University of Hull, Hull, United Kingdom

    C. J. Gray & S. M. Taylor

Authors
  1. J. A. Brown
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  2. C. J. Gray
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  3. S. M. Taylor
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Brown, J.A., Gray, C.J. & Taylor, S.M. Direct effects of angiotensin II on glomerular ultrastructure in the rainbow trout, Salmo gairdneri . Cell Tissue Res 260, 315–319 (1990). https://doi.org/10.1007/BF00318634

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  • DOI: https://doi.org/10.1007/BF00318634

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