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A case of splenic vein occlusion caused by the intravenous tumor thrombus of nonfunctioning islet cell carcinoma

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Abstract

We report herein a case of successfully treated advanced, nonfunctioning islet cell carcinoma associated with left-sided portal hypertension. The splenic vein was obstructed by a huge intravenous tumor thrombus developing from the main pancreatic tumor. Direct invasion to adjacent organs such as the spleen, colon, left kidney and stomach was also observed, although liver metastasis was not present. Radical resection was carried out with removal of these five involved organs and the patient is alive without recurrence more than 5 years after surgery.

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References

  1. Japan Pancreas Society. General rules for cancer of the pancreas, (in Japanese) The 3rd edition, Tokyo: Kanehara, 1986:9–13

    Google Scholar 

  2. Dial PF, Braasch JW, Rossi RL, Lee AK, Jin G (1985) Management of nonfunctioning islet cell tumor of the pancreas. Surgical Clinics of North America 65:291–299

    Google Scholar 

  3. Kent RB, Heerden JA, Weiland LH (1981) Nonfunctioning islet cell tumors. Ann Surg 193:185–190

    Google Scholar 

  4. Legaspi A, Brennan MF (1988) Management of islet cell carcinoma. Surgery 104:1018–1023

    Google Scholar 

  5. Sutton JP, Yarborough DY, Richards JT, Charleston (1970) Isolated splenic vein occlusion. Arch Surg 100:623–626

    Google Scholar 

  6. Babb RR (1976) Splenic vein obstruction: A curable cause of variceal bleeding. Digestive Disease 21:512–513

    Google Scholar 

  7. Muhletaler C, Gerlock AJ, Goncharenko V, Avant GR, Flexner JM (1979) Gastric varices secondary to splenic vein occlusion: Radiographic diagnosis and clinical significance. Diagnostic Radiology 132:593–598

    Google Scholar 

  8. Little AG, Moossa AR (1981) Gastrointestinal hemorrhage from left-sided portal hypertension. Am J Surg 141:153–158

    Google Scholar 

  9. Keith RG, Mustard RA, Saibil EA (1982) Gastric variceal bleeding due to occlusion of splenic vein in pancreatic disease. Can J Surg 25:301–304

    Google Scholar 

  10. Ku Y, Kawa Y, Fujiwara S, Nishiyama H, Tanaka Y, Okumura S, Ohyanagi H, Saitoh Y (1989) Hemodynamic study of occlusion of the splenic vein caused by carcinoma of the pancreas. Surg Gynecol & Obstet 168:17–24

    Google Scholar 

  11. Maclean N, Falconer CWA, Gilmour IEW, Webb FN (1970) Islet cell tumors of the pancreas with portal varices and gastro-intestinal hemorrhage. J R Coll Surg Edinburgh 15:206–212

    Google Scholar 

  12. Wolf JH, Long RJ, Miller FJ, Jeffries GH (1977) Pancreatic islet cell tumor presenting as bleeding gastric varices secondary to splenic vein occlusion. Digestive Diseases 22:652–655

    Google Scholar 

  13. Bok EJ, Cho KJ, Williams DM, Brady TM, Weiss CA, Forrest ME (1984) Venous involvement in islet cell tumors of the pancreas. AJR 142:319–322

    Google Scholar 

  14. Miyoshi A, Naito T, Ueki T, Tomokiyo A, Uchiyama H, Mano M, Kobayashi S, Nakayama Y, Yoshida K, Nakayama K, Koga M, Yamaguchi T (1979) Two cases of non-functioning islet cell carcinoma. (in Japanese) Geka (Surgery) 41:1401–1405

    Google Scholar 

  15. Miyamoto Y, Sudoh E, Oowada S, Mizuguchi S, Kamio M, Kawai T, Izuo M (1983) Non-functioning islet cell carcinoma: Report of a case and review of the literature. (in Japanese) Tan To Sui 4:827–833

    Google Scholar 

  16. Gallardo-Navarra V, Phillips E, Neyfeld P, Sakwa S (1973) Segmental portal hypertension and islet cell adenoma of the pancreas. JAMA 22:1466

    Google Scholar 

  17. Miyagawa S, Miura K, Kawase K, Kondo N, Iwasa K, Isaji H, Kurahashi M, Sai S, Fuku K, Horiguchi Y, Nakano H (1980) A case of islet cell tumor (nonfunctioning) with intravenous tumor growth in portal vein. (in Japanese) (Jpn J Gastroenterol Surg) 13:300

    Google Scholar 

  18. Suzuki E, Saito S, Sato K, Kurita Y, Suzuki M, Kadota H, Yanagihara M (1981) A case of nonfunctioning islet cell carcinoma. (in Japanese) Nippon Naika Gakkai Zashi 70:134

    Google Scholar 

  19. Seo Y, Oomachi S, Kaneshima R, Miyazaki M, Matsuguchi S, Tomoda H, Furusawa G (1981) Four cases of nonfunctioning islet cell carcinoma. (in Japanese) (J Jpn Soc Clin Surg) 42:113

    Google Scholar 

  20. Thompson GB, Heerden JA, Grant CS, Carney JA, Ilstrup DM (1988) Islet cell carcinoma of the pancreas: A twenty-year experience. Surgery 104:1011–1017

    Google Scholar 

  21. Broder LE, Carter SK (1973) Pancreatic islet cell carcinoma: II. Results of therapy with streptozotocin in 52 patients. Ann Intern Med 79:108–118

    Google Scholar 

  22. Moetel CG, Hanley JA, Johnson LA (1980) Streptozotocin alone compared with streptozotocin plus fluorouracil in the treatment of advanced islet-cell carcinoma. N Engl J Med 303:1189–1194

    Google Scholar 

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Authors and Affiliations

  1. The Second Department of Surgery, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, 553, Osaka, Japan

    Makoto Watase, Masato Sakon, Morito Monden, Yoshio Miyoshi, Takeshi Tono, Takeru Ichikawa, Hitoshi Shiozaki & Takesada Mori

  2. the Department of Surgery, Tennouji Hospital, Japan

    Makoto Watase, Masato Sakon, Morito Monden, Yoshio Miyoshi, Takeshi Tono & Naoyuki Kubota

  3. the Department of Surgery, Yao City Hospital, Japan

    Makoto Watase, Masato Sakon, Morito Monden, Yoshio Miyoshi, Takeshi Tono & Hiroshi Okuda

  4. the Department of Surgery, Osaka Teishin Hospital, Osaka, Japan

    Makoto Watase, Masato Sakon, Morito Monden, Yoshio Miyoshi, Takeshi Tono & Jun Okamura

Authors
  1. Makoto Watase
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  2. Masato Sakon
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  3. Morito Monden
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  4. Yoshio Miyoshi
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  5. Takeshi Tono
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  6. Takeru Ichikawa
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  7. Naoyuki Kubota
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  8. Hitoshi Shiozaki
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  9. Hiroshi Okuda
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  10. Jun Okamura
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  11. Takesada Mori
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Watase, M., Sakon, M., Monden, M. et al. A case of splenic vein occlusion caused by the intravenous tumor thrombus of nonfunctioning islet cell carcinoma. Surg Today 22, 62–65 (1992). https://doi.org/10.1007/BF00326127

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  • DOI: https://doi.org/10.1007/BF00326127

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