Summary
It was examined whether genetic factors are involved in the expression of alpha-2 adrenergic receptors on human platelets, as measured with 3H-yohimbine as ligand. The twin series comprised 17 monozygotic and 15 dizygotic adult, healthy, male, drug-free twin pairs. For control of intraindividual and interassay variation, 13 unrelated pairs of subjects were examined. Bmax values for 3H-yohimbine binding (range 91–305 fmol/mg protein) proved to be under considerable genetic control; this was not the case for KD values. Different possible genetic mechanisms are discussed.
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References
Brodde OE, Anlauf M, Graben N, Bock KD (1982) Age-dependent decrease of alpha-adrenergic receptor number in human platelets. Eur J Pharmacol 81:345–347
Brown MS, Goldstein JL (1976) Familial hypercholesterolemia: a genetic defect in the low-density lipoprotein receptor. N Engl J Med 294:1386–1390
Davies IB, Mathias CJ, Sudera D, Sever PS (1982) Agonist regulation of alpha-adrenergic receptor responses in man. J Cardiovasc Pharmacol 4 (Suppl 1):S139-S144
Friedl W, Propping P, Weck B (1983) 3H-Imipramine binding in platelets: influence of varying proportions of intact platelets in membrane preparations on binding. Psychopharmacology 80:96–99
Griffin JE, Wilson JD (1980) The syndromes of androgen resistance. N Engl J Med 302:198–209
Jakobs KH (1978) Synthetic alpha-adrenergic agonists are potent alpha-adrenergic blockers in human platelets. Nature 274:819–820
Maartmann-Moe K, Magnus P, Golden W, Berg K (1981) Genetics of the low density lipoprotein receptor: III. Evidence for multiple normal alleles at the low density lipoprotein receptor locus. Clin Genet 20:113–129
Magnus P, Maartmann-Moe K, Golden W, Nance WE, Berg K (1981) Genetics of the low density lipoprotein receptor: II. Genetic control of variation in cell membrane low density lipoprotein receptor activity in cultured fibroblasts. Clin Genet 20:104–112
Motulsky HJ, Insel PA (1982) Adrenergic receptors in man. Direct identification, physiologic regulation, and clinical alterations. N Engl J Med 307:18–29
Motulsky HJ, Shattil SJ, Insel PA (1980) Characterization of alpha2-adrenergic receptors on human platelets using 3H-yohimbine. Biochem Biophys Res Commun 97:1562–1570
Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346–356
Propping P (1977) Genetic control of ethanol action on the central nervous system. An EEG study in twins. Hum Genet 35:309–334
Rüdiger HW, Dreyer M (1983) Pathogenetic mechanisms of hereditary diabetes mellitus. Hum Genet 63:100–106
Schultz G, Aktories K, Böhme E, Gerzer R, Jakobs KH (1982) Signal transformation mediated by membrane receptors for hormones and neurotransmitters. Mol Immunol 19:1207–1214
Vogel F, Motulsky AG (1979) Human genetics. Problems and approaches. Springer, Berlin Heidelberg New York
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Propping, P., Friedl, W. Genetic control of adrenergic receptors on human platelets. A twin study. Hum Genet 64, 105–109 (1983). https://doi.org/10.1007/BF00327103
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DOI: https://doi.org/10.1007/BF00327103