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Oncogene proteins as biomarkers in the molecular epidemiology of occupational carcinogenesis

The example of the ras oncogene-encoded p21 protein

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Summary

The use of oncogene proteins as biomarkers offers a new approach to the molecular epidemiologic evaluation of occupational carcinogenesis. The ras oncogene-encoded p21 protein represents a prototype for this type of study, since it is known to be activated by common occupational carcinogens, is frequently found in human tumors of occupational concern, and, at least in certain instances, appears to be expressed relatively early in the disease process, allowing the possibility of early detection and intervention. Herein, we review our experience with the use of immunologic detection of p21 in cohorts with cancer or at risk for the development of cancer due to their occupational exposures. The results suggest that p21 (particularly when used with other oncoproteins and biomarkers such as PAH-DNA adducts) will indeed be a useful addition to the growing armamentarium of molecular epidemiologic biomarkers in the study of occupational carcinogenic mechanisms and in the detection and prevention of occupational cancers.

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Authors and Affiliations

  1. Director of Occupational Medicine, Division of Environmental Sciences, Department of Medicine, and Comprehensive Cancer Center, Columbia University, 60 Haven Avenue, B-1, 10032, New York, NY, USA

    Paul W. Brandt-Rauf

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  1. Paul W. Brandt-Rauf
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This paper was delivered at the presentation of the Robert R. J. Hilker Award in Occupational Medicine, Chicago, Illinois, March 30, 1990

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Brandt-Rauf, P.W. Oncogene proteins as biomarkers in the molecular epidemiology of occupational carcinogenesis. Int. Arch Occup Environ Heath 63, 1–8 (1991). https://doi.org/10.1007/BF00406190

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  • DOI: https://doi.org/10.1007/BF00406190

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