Skip to main content
SpringerLink
Log in

Concentration of ampicillin in the vitreous after cryocoagulation

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

After transconjunctival cryocoagulation rabbits received 100 mg/kg ampicillin intravenously. At different times in serum, aqueous humor, and in vitreous the concentrations of ampicillin were determined by the agar diffusion method. During the first 90 min after injection the concentration of ampicillin in the vitreous of the treated eyes reached 1 μg/ml. Up to 3 days after coagulation such high concentrations were found. Five and ten days after coagulation the concentration reached 0.48 μg/ml (mean value). With progressive cicatrization of the cryospots less ampicillin was found in the vitreous. In the vitreous of the untreated control eyes only minimal or no ampicillin was found in all of our experiments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Daily, M.J., Peyman, G.A., Fishman, G.: Intravitreal Injection of Methicillin for treatment of endophthalmitis. Amer. J. Ophthal. 76, 343–350 (1973)

    Google Scholar 

  • Faigenbaum, S.J., Boyle, G.L., Prywes, A.S., Abel, R., Leopold, J.H.: Intraocular penetration of amoxicillin. Amer. J. Ophthal. 82, 598–603 (1976)

    Google Scholar 

  • Forster, R.K., Zachary, I.G., Cottingham, A.J., Norten, E.W.D.: Further observations on the diagnosis, cause and treatment of endophthalmitis. Amer. J. Ophthal. 81, 52–56(1976)

    Google Scholar 

  • Kasbeer, R.T., Peyman, G.A.: Intravitreal oxacillin in experimental staphylococcal endophthalmitis. Albrecht v. Graefes Arch. klin. exp. Ophthal. 196, 279–287 (1975)

    Google Scholar 

  • Nelson, P., Peyman, G.A., Bennett, T.O.: BB-K8 a new aminoglycoside for intravitreal injection in bacterial endophthalmitis. Amer. J. Ophthal. 78, 82–89 (1974)

    Google Scholar 

  • Röber, H., Röber, H.-J., Klaas, D., Sous, H.: Nachweis von Antibiotika im Glaskörper nach Lichtkoagulation der Retina. 5ter Kongreß der Europäischen Ophthalmologischen Gesellschaft, Hamburg, 5.–9. April 1976

  • Röber-Schwietzer, H., Röber, H., Klaas, D., Sous, H.: Ampicillinkonzentration im Glaskörper nach Lichtkoagulation der Retina. Klin. Mbl. Augenhk. (in press)

  • Schenk, A.G., Peyman, G.A., Paque, J.T.: The intravitreal use of carbenicillin (GEOPEN) for treatment of pseudomonas endophthalmitis. Acta Ophthal. 52, 707–717 (1974)

    Google Scholar 

  • Zachary, J.G., Forster, R.K.: Experimental intravitreal gentamycin. Amer. J. Ophthal. 82, 604–611 (1976)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Rheinisch-Westfälische Technische Hochschule, Goethestr. 27-29, D-5100, Aachen, Republic of Germany

    Hilka Röber, Werner Göring, Heinz Sous & Martin Reim

Authors
  1. Hilka Röber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Werner Göring
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Heinz Sous
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Martin Reim
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Röber, H., Göring, W., Sous, H. et al. Concentration of ampicillin in the vitreous after cryocoagulation. Albrecht von Graefes Arch. Klin. Ophthalmol. 204, 275–280 (1977). https://doi.org/10.1007/BF00415321

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00415321

Keywords

Search

Navigation