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Differential sensitivity to amphetamine following long-term treatment with clozapine or haloperidol

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Abstract

When rats were pretreated for 8 consecutive days with 2.0 mg/kg haloperidol, injection of 2.5 or 5.0 mg/kg d-amphetamine 2 or 6 days later resulted in a larger increase in oral behaviors and a more prolonged period of focused stereotypy than in saline-pretreated controls. This increased sensitivity to amphetamine is consistent with the effects of a chronic haloperidol-induced increase in dopamine receptor sensitivity. In contrast, long-term treatment with either d-amphetamine or clozapine produced complex changes in the multiphasic behavioral response to amphetamine, which cannot be explained solely by a shift in the sensitivity of dopamine receptors.

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Rebec, G.V., Peirson, E.E., McPherson, F.A. et al. Differential sensitivity to amphetamine following long-term treatment with clozapine or haloperidol. Psychopharmacology 77, 360–366 (1982). https://doi.org/10.1007/BF00432771

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  • DOI: https://doi.org/10.1007/BF00432771

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