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Primary hypothyroidism associated with pituitary enlargement, slipped capital femoral epiphysis and cystic ovaries

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Abstract

A case of primary hypothyroidism with pituitary enlargement, slipped capital femoral epiphysis and cystic ovaries is reported. The pituitary abnormality and cystic ovaries disappeared dramatically after thyroid hormone therapy. Hip pinning was performed. The recognition of these associations may eliminate unnecessary surgery and lead to the choice of hormone replacement therapy.

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Abbreviations

TGHA:

antithyroglobulin haemagglutination antibody

MCHA:

antithyroid microsome haemagglutination antibody

PRL:

serum prolactin

GH:

growth hormone

SCFE:

slipped capital femoral epiphysis

References

  1. Adams WC, Senseman DM (1976) Aromatization of androstenedione by induced polycystic ovaries in the rat. J Steroid Biochem 7:309–310

    Google Scholar 

  2. Di Chiro G, Nelson KB (1962) The volume of the sella turcica. Am J Roentgenol 87:989–1008

    Google Scholar 

  3. Filder MW, Brook GD (1974) Slipped upper femoral epiphysis following treatment with human growth hormone. J Bone Joint Surg 56-A:1719–1722

    Google Scholar 

  4. Gup RS, Sheeler LR, Maeder MC, Tew JM (1982) Pituitary enlargement and primary hypothyroidism: a report of two cases with sharply contrasting outcomes. Neurosurgery 11:792–794

    Google Scholar 

  5. Hemady ZS, Siler-Khodr TM (1978) Precocious puberty in juvenile hypothyroidism. J Pediatr 92:55–59

    Google Scholar 

  6. Hirano T, Stamelos S, Harris V, Dumbovic N (1978) Association of primary hypothyroidism and slipped capital femoral epiphysis. J Pediatr 93:262–264

    Google Scholar 

  7. Jayakumar S (1980) Slipped capital femoral epiphysis with hypothyroidism treated by nonoperative method. Clin Orthop 151: 179–182

    Google Scholar 

  8. Lindsay AN, Voorhess ML, MacGillivray MH (1980) Multicystic ovaries detected by sonography in children with hypothyroidism. Am J Dis Child 134:588–592

    Google Scholar 

  9. Mandl AM (1957) Factors influencing ovarian sensitivity to gonadotrophins. J Endocrinol 15:448–457

    Google Scholar 

  10. Primiano GA, Ohio A, Hughston JC (1971) Slipped capital femoral epiphysis in a true hypogonadism male (Klinefelter's mosaic XY/XXY). J Bone Joint Surg 53-A:597–601

    Google Scholar 

  11. Reevens GD, Gibbs M, Paulshock BZ, Rosenblum H (1978) Gigantism with slipped capital femoral epiphysis. Am J Dis Child 132:529–530

    Google Scholar 

  12. Syversten A, Haughton VM, Williams AL, Cusick JF (1979) The computed tomographic appearance of the normal pituitary gland and pituitary microadenomas. Radiology 133:385–391

    Google Scholar 

  13. Uozumi T, Sakoda K, Ohta M, Iguchi T, Mori S (1983) The image diagnosis of the pituitary adenomas. In: Shizume K, Imura H, Shimizu N (eds) Proceeding of the seventh Asia and Oceania congress of endocrinology. Excerpta Medica, Amsterdam, pp 469–473

    Google Scholar 

  14. Van Wyk JJ, Grumbach MM (1960) Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback. J Pediatr 57:416–435

    Google Scholar 

  15. Voogt JL, Meites J (1971) Effects of an implant of prolactin in media eminence of pseudopregnant rats on serum and pituitary LH, FSH and prolactin. Endocrinology 88:286–292

    Google Scholar 

  16. Wood LC, Olichney M, Locke H, Crispell KR, Thornton N Jr, Kitay JI (1965) Syndrome of juvenile hypothyroidism associated with advanced sexual development: report of two new cases and comment on the management of an associated ovarian mass. J Clin Endocr 25:1289–1295

    Google Scholar 

  17. Yamada T, Tsukui T, Ikejiri K, Yukimura Y, Kotani M (1976) Volume of sella turcica in normal subjects and in patients with primary hypothyroidism and hyperthyroidism. J Clin Endocrinol Metab 42:827–822

    Google Scholar 

  18. Yamamoto K, Saito K, Takai T, Naito M, Yoshida S (1983) Visual field defects and pituitary enlargement in primary hypothyroidism. J Clin Endocrinol Metab 57: 283–287

    Google Scholar 

  19. Zubrow AB, Lane JM, Parks JS (1978) Slipped capital femoral epiphysis occurring during treatment for hypothyroidism. J Bone Joint Surg 60-A:256–258

    Google Scholar 

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Nishi, Y., Masuda, H., Iwamori, H. et al. Primary hypothyroidism associated with pituitary enlargement, slipped capital femoral epiphysis and cystic ovaries. Eur J Pediatr 143, 216–219 (1985). https://doi.org/10.1007/BF00442143

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  • DOI: https://doi.org/10.1007/BF00442143

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