Abstract
Clinical and hematological findings of 83 newborn infants with septicemia were studied retrospectively. Symptoms before, at the beginning and at the peak of septicemia were studied and a score system was created on the basis of clinical and hematological symptoms. In prospective studies, 39 neonates with sepsis, 183 neonates as control group, 42 with amniotic infection, 28 with postasphyxia syndrome and 28 premature babies with cerebral hemorrhage were investigated.
The new sepsis score is helpful for early detection of septicemia and differential diagnosis in newborn infants.
Similar content being viewed by others
References
Akenzua GI, Hui YT, Milner R, Zipursky A (1974) Neutrophil and band counts in the diagnosis of neonatal infections. Pediatrics 54:38–42
Belohradsky BH, Roos R, Marget W (1978) Exchange transfusion in neonatal septicemia. Infection 6 [Suppl 1]:139–144
Boyle RJ, Chandler BD, Stonestreet BS, Oh W (1978) Earlyidentification of sepsis in infants with respiratory distress. Pediatrics 62:744–750
Corrigan JJ (1974) Throbocytopenia: A laboratory sign of septicemia in infants and children. J Pediat 85:219–221
Diekmann L (1978) Klinik der Neugeborenen-Septikämie. In: Neugeborenen-Infektionen. Bücherei des Pädiaters Nr. 80. Enke, Stuttgart
Fehlmann U, Loher E, Fanconi A (1976) Quantitative Untersuchungen der stabkernigen und segmentkernigen neutrophilen Granulozyten beim Neugeborenen. Helv Paediat Acta 31:21–32
Klaus MH, Fanaroff AA (1978) Das Risikoneugeborene. Gustav Fischer, Stuttgart New York
Kleihauer E (1978) Hämatologie. Springer, Berlin Heidelberg New York
Lawson EE, Grand RJ, Neff RK, Cohen LF (1978) Clinical estimation of liver span in infants and children. Am J Dis Child 132: 474–476
Manroe BL, Weinberg AG, Rosenfeld CR, Browne R (1979) The neonatal blood count in health and disease: I. Reference values for neutrophilic cells. J Pediatr 95:89–98
Mathy KA, Koepke JA (1974) The clinical usefulness of segmented vs. stab neutrophil criteria for differential leukocyte count. Am J Clin Pathol 61:947–958
Philip AGS (1981) Decreased use of antibiotics using a neonatal sepsis screening technique. J Pediatr 98:795–799
Schaffer AJ, Avery ME (1977) Disease of the newborn, 4th edn. WB Saunders Comp, Philadelphia London Toronto
Squire E, Favara B, Todd J (1979) Diagnosis of neonatal bacterial infection; Hematologic and pathologic findings in fatal and nonfatal cases. Pediatrics 64:60–64
Staudt F, Pringsheim W, Zeisel HJ (1980) Die Streptokokken-infektion bei Neugeborenen. Klin Pädiatr 192:351–357
Talluto MR (1975) Hematological findings in acute infections and septicemias. Am J Med Technol 41:377–386
Töllner U, Pohlandt F (1976) Septicemia in the newborn due to gram-negative bacilli. Eur J Pediat 123:243–254
Töllner U, Pohlandt F, Heinze F, Henrichs I (1977) Treatment of septicaemia in the newborn infant: Choice of initial antimicrobial drugs and role of exchange transfusion. Acta Paediatr Scand 66: 605–610
Töllner U (1979) Früherkennung der Sepsis im Neugeborenenalter. 28. Tagung der Nordwestdeutschen Gesellschaft für Kinderheilkunde, Wilhelmshaven 1979
Töllner U, Heinrich R (1980) Die Austauschtransfusion als neue therapeutische Möglichkeit bei Sepsis nach Operationen im Neugeborenenalter. In: Infektionsprobleme in der Neugeborenenchirurgie. Thieme, Stuttgart New York
Töllner U, Pohlandt F, Kleihauer E (1980) Neonatal infection and white blood cell count (Letter). Pediatrics 65:1196–1197
Töllner U (1980) Sepsis-Score. Ein Weg zur Früherkennung der Sepsis im Neugeborenenalter. Kongreß der Deutschen Gesellschaft für Bluttransfusion und Immunhämatologie, Linz
Töllner U, Pohlandt F, Vanek E, Kohne E, Kleihauer E (1981) Hämolyse als erstes Zeichen einer Sepsis mit Clostridium perfringens. Klin Pädiatr 193:398–400
Wille L, Oppermann HC, Lutz P (1978) Das Spektrum der B-Streptokokken-Infektionen bei Neugeborenen. In: Neugeborenen-Infektionen. Bücherei des Pädiaters. Nr. 80. Enke, Stuttgart
Xanthou M (1970) Leukocyte blood picture in healthy full-term and premature babies during neonatal period. Arch Dis Child 45:242–249
Xanthou M (1972) Leukocyte blood picture in ill newborn babies. Arch Dis Child 47:741–746
Zipursky A, Palko J, Miller R, Akenzua GI (1976) The hematology of bacterial infections in premature infants. Pediatrics 57:839–853
Author information
Authors and Affiliations
Additional information
Statistical assistance from Prof. W. Gaus und I. Borchert
Rights and permissions
About this article
Cite this article
Töllner, U. Early diagnosis of septicemia in the newborn. Eur J Pediatr 138, 331–337 (1982). https://doi.org/10.1007/BF00442511
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00442511