Summary
The binding of rifampicin to human plasma proteins has been investigated by equilibrium dialysis. Plasma from eleven healthy subjects not taking drugs bound 87–91% of added rifampicin. Binding was lower (84–88%) in plasma from ten tuberculous patients on long-term treatment with rifampicin. Physiological concentrations of human albumin, gamma globulin and fibrinogen bound 41, 10 and 8%, respectively, of added rifampicin. Isoniazid, p-aminosalicylic acid, streptomycin and ethambutol did not significantly affect rifampicin binding to plasma proteins.
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Boman, G., Ringberger, V.A. Binding of rifampicin by human plasma proteins. Eur J Clin Pharmacol 7, 369–373 (1974). https://doi.org/10.1007/BF00558209
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DOI: https://doi.org/10.1007/BF00558209