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The early phase of experimental acute renal failure

VI. The influence of furosemide

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Abstract

Experiments were performed to determine whether furosemide, given in doses high enough to induce a strong diuresis and to inhibit the mechanism of tubuloglomerular feedback, offers any protection from acute renal failure induced by a nephrotoxin or ischaemia. Microperfusion of the loop of Henle revealed that a tubular furosemide concentration of 5·10−5 mol·l−1 was necessary to fully inhibit the tubuloglomerular feedback response to a raised sodium chloride concentration at the macula densa. The infusion of furosemide systemically to achieve such concentrations in the tubule resulted in an improvement in renal function when given before or after the nephrotoxin but was without effect when given before or after ischaemia. Measurements of furosemide concentrations in the urine, however, confirmed that sufficient amounts were applied to inhibit the feedback mechanism. It is concluded from this and similar studies that furosemide is only beneficial in models of acute renal failure with an obstructive or nephrotoxic pathogenesis, in which it acts by flushing out the noxious material and not by inhibiting the mechanism of tubuloglomerular feedback.

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Authors and Affiliations

  1. Physiologisches Institut, Universität München, Pettenkoferstrasse 12, D-8000, München 2, Federal Republic of Germany

    June Mason, Hermann Kain, Johanna Welsch, Jürgen Schnermann, Elizabeth Murdaugh, Paulo Faltay, Sigrid Pätz & Maria Steff

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  1. June Mason
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  2. Hermann Kain
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Mason, J., Kain, H., Welsch, J. et al. The early phase of experimental acute renal failure. Pflugers Arch. 392, 125–133 (1981). https://doi.org/10.1007/BF00581260

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