Abstract
A direct dose-dependent stimulation or inhibition by val5-angiotensin II of sodium reabsorption in the rat proximal nephron has been shown using stationary microperfusion combined with perfusion of the peritubular capillaries. Since the circulating form of the hormone in the rat has been suggested to be the ile5-analogue these experiments have been repeated using the ile5-peptide at peritubular concentrations covering the normal physiological range (10−10–10−13M). Comparison of the results with the previously published data shows no significant difference between the actions of these two analogues. At the concentrations tested both caused significant stimulation of sodium reabsorption with a maximum effect at 10−11M.
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Harris, P.J., Young, J.A.: Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflűgers Arch.367, 295–297 (1977)
Jorgenson, E.C., Rapaka, S.R., Windridge, G.C.: Angiotensin II analogs. 6. Stereochemical factors in the 5 position influencing pressor activity. 1. J. Med. Chem.14, 899–903 (1971)
Khosla, M.C., Smeby, R.R., Bumpus, F.M.: Structure-activity relationship in angiotensin II analogs. In: Angiotensin.Handbuch der exp. Pharmakol.Bd. 37, 126. Berlin-Heidelberg-New York: Springer 1974
Oster, P., Hackenthal, E., Hepp, R.: Radioimmunoassay of angiotensin II in rat plasma. Experientia29, 353–354 (1973)
Powell-Jackson, J.D., Brown, J.J., Lever, A.F., MacGregor, J., Macadam, R.F., Titterington, D.M., Robertson, J.I.S., Waite, M.A.: Protection against acute renal failure in rats by passive immunisation against angiotensin II. Lancet, 774–776 (1972)
Schoelkens, B.A., Wissman, H., Lindner, E., Geiger, R.: 1, 8-disubstituted analogues of (Ile5) and (Val5) angiotensin II: Difference in potency and specificity of angiotensin II-antagonistic activity. Hoppe-Seyler's Z. Physiol. Chem.357, 825–838 (1976)
Semple, P.F., Morton, J.J.: Angiotensin II and angiotensin III in rat blood. Circ. Res.38, Supp. II, 122–126 (1976)
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Harris, P.J. Stimulation of proximal tubular sodium reabsorption by ile5 angiotensin II in the rat kidney. Pflugers Arch. 381, 83–85 (1979). https://doi.org/10.1007/BF00582337
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DOI: https://doi.org/10.1007/BF00582337