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Malignant Rhabdoid tumor of the kidney. Histopathology, ultrastructure and comments on differential diagnosis

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Summary

Clinical and histopathological features of two cases of malignant rhabdoid tumor of the kidney are presented. One of these cases was also studied by electron microscopy. Histologically, both tumors consisted of an admixture of undifferentiated polygonal or elongated cells and cells with abundant eosinophilic cytoplasm frequently containing hyaline globular structures. Ultrastructurally, these cytoplasmic inclusions were composed of large masses of actin-size and intermediate-size filaments. The poor prognosis of this type of tumor is emphasized and histological criteria for differential diagnosis from other malignant renal tumors of childhood and adolescence are discussed.

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Dedicated to Prof. Dr. med. Volker Becker, Head of the Department of Pathology, University of Erlangen-Nürnberg on the occasion of his 60th birthday.

Supported by a grant from Stiftung Volkswagenwerk (Kindertumorregister)

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Schmidt, D., Harms, D. & Zieger, G. Malignant Rhabdoid tumor of the kidney. Histopathology, ultrastructure and comments on differential diagnosis. Vichows Archiv A Pathol Anat 398, 101–108 (1982). https://doi.org/10.1007/BF00585617

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